Antiangiogenic Effect of Alkaloids

Abstract

Alkaloids are among the natural phytochemicals contained in functional foods and nutraceuticals and have been suggested for the prevention and/or management of oxidative stress and inflammation-mediated diseases. In this review, we aimed to describe the effects of alkaloids in angiogenesis, the process playing a crucial role in tumor growth and invasion, whereby new vessels form. Antiangiogenic compounds including herbal ingredients, nonherbal alkaloids, and microRNAs can be used for the control and treatment of cancers. Several lines of evidence indicate that alkaloid-rich plants have several interesting features that effectively inhibit angiogenesis. In this review, we present valuable data on commonly used alkaloid substances as potential angiogenic inhibitors. Different herbal and nonherbal ingredients, introduced as antiangiogenesis agents, and their role in angiogenesis-dependent diseases are reviewed. Studies indicate that angiogenesis suppression is exerted through several mechanisms; however, further investigations are required to elucidate their precise molecular and cellular mechanisms, as well as potential side effects.

Anticancer And Antiangiogenic Activities Of Alkaloids Isolated From Lantana Camara By Adsorption On The Magnetic Nanoparticles

“…Curbing tumor angiogenesis will stop blood supply and oxygen needed for growing tumors; besides, it cuts the cancer cell's avenues to metastasis to distant organs [48,49]. There are active alkaloids driven from plants that have potent antiangiogenic effects, for example, berberine, noscapine, brucine, evodiamine, sanguinarine, capsaicin, harmine, and pterogynidine, which block angiogenesis cascade in endothelial cells by downregulation of STAT3 and b-catenin signaling, as well as Akt phosphorylation [15,49,50]. Sinomenine, brucine, and halofuginone can directly inhibit angiogenesis growth factors such as Smad protein, VEFG, TNF-a, and HIF-1a [50].…”

“…There are active alkaloids driven from plants that have potent antiangiogenic effects, for example, berberine, noscapine, brucine, evodiamine, sanguinarine, capsaicin, harmine, and pterogynidine, which block angiogenesis cascade in endothelial cells by downregulation of STAT3 and b-catenin signaling, as well as Akt phosphorylation [15,49,50]. Sinomenine, brucine, and halofuginone can directly inhibit angiogenesis growth factors such as Smad protein, VEFG, TNF-a, and HIF-1a [50]. In previous work, the aqueous extract of L. camara was investigated for its effect on the angiogenesis process using in vitro and in vivo animal models; it showed remarkable antiangiogenic properties [51].…”

Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review

“…Anti-angiogenic property of the alkaloids was achieved through the down-regulation (VEGF, TNF-α and HIF-1α messengers) and/or up-regulation (apoptotic genes) of certain factors (Tang et al, 2009). Alkaloids exert its actions either directly by blocking the angiogenic cascade: berberine, noscapine, brucine, evodiamine, homoharringtonine, matrine and tetrandrine (Alasvand et al, 2019) or indirectly by blocking the STAT3 signaling pathway: matrine and tetrandrine (Zhao et al, 2018). Furthermore,other actions of the plant alkaloidsinclude:inhibiting the β-catenin pathway such as evodiamine (Shi et al, 2016), regulating the Akt phosphorylation which includesanguinarine, capsaicin, taspine, harmine and pterogynidine (Min et al, 2004) and CDK expression (Zhang et al, 2011) and/or NF-κB translocation (Hamsa and Kuttan, 2010).…”

Angioregulatory microRNAs in Colorectal Cancer

“…The angiogenic switch of CRC involves VEGF secretion from cancer cells under hypoxic conditions which triggers angiogenesis via VEGFR expressed on ECs. MiRNAs were shown to suppress VEGF expression in tumor cells and VEGFR expression in ECs [33,34]. Thus, on the one hand, miRNAs can regulate communication between tumor cells and different components of the TME by modulating the expression of growth factors or their receptors.…”