Antiangiogenic Effect of Ficus deltoidea Jack Standardised Leaf Extracts

Shafaei, Armaghan; Muslim, Nahdzatul Syima; Nassar, Zeyad D.; Aisha, Abdalrahim F. A.; Majid, Amin Malik Shah Abdul; Ismail, Zhari

doi:10.4314/tjpr.v13i5.16

Cited by 14 publications

(14 citation statements)

References 15 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As both FDM and FDS showed no signs of cytotoxicity ( Table 3 ), this could be interpreted as a positive sign in that they are relatively non-toxic, rendering them safe for consumption as an alternative medicine and health supplement. However, the US National Cancer Institute (NCI) states that a plant extract is considered toxic if it causes cytotoxicity with IC 50 < 20 µg/ml ( Shafaei et al, 2014 ). Thus, FDB also can be considered non-toxic to WRL68 cells.…”

Section: Discussionmentioning

confidence: 99%

The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves

Abrahim

Abdul‐Rahman

Aminudin

2018

PeerJ

View full text Add to dashboard Cite

Leaves from three varieties of Ficus deltoidea, colloquially termed small- (FDS), medium- (FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid content, antioxidant activity, and cytotoxicity of the fractions were investigated. The EAF had the highest phenolic and flavonoid content compared to the other FDS fractions. Conversely, the FDM crude extract had the highest phenolic and flavonoid content compared to the other FDM samples. Antioxidant activity was highest in the FDB crude extract. Ultra-high–performance liquid chromatography showed that two compounds, vitexin and coumaric acid, were present in the FDB crude extract. Additionally, the F. deltoidea leaves caused no signs of toxicity in a normal liver cell line. Our findings show that F. deltoidea varieties have excellent antioxidant activity with no cytotoxic effects on normal liver cells.

show abstract

Section: Discussionmentioning

confidence: 99%

The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves

Abrahim

Abdul‐Rahman

Aminudin

2018

PeerJ

View full text Add to dashboard Cite

show abstract

“…Anticancer effect: Shafaei et al (2014) in his study shows that standardized leaf extract of F. deltoidea have the anticancer potential. In his study, the leaf extract have the ability as antiangiogenic towards animal cells.…”

Section: Pharmacological Propertiesmentioning

confidence: 97%

Ficus deltoidea: Review on Background and Recent Pharmacological Potential

Jamaludin¹,

Khandaker²,

Boyce³

2015

J. of Agronomy

View full text Add to dashboard Cite

Ficus deltoidea is a native plant of Malaysia which is very potential plant for varied purposes. It has diversed morphology and was spread throughout Malaysia and adjacent countries. Its great potential had been valued by the old folks and now it is getting famous as more attention given in exploring herbs as an alternative for medicine. Ficus deltoidea is an ultimate source of antioxidant and natural products. It is commercialized as tea and is proposed as a possible supplement for type II diabetes patients. Ficus deltoidea studied for its numerous pharmacological properties such as antioxidant and antidiabetic properties, anti-inflammation and antinociceptive activity, wound healing activity, antiulcerogenic effect, antibacterial, anticancer and also it's potential as an uterotonic agent. This article review provide more thorough information about F. deltoidea plants in detail in term of plant, origin, morphology, ecology, variety, commercial usage and its pharmacological benefits.

show abstract

“…Ficus deltoidea Jack, commonly known as mistletoe fig, found in several parts of the globe, has been traditionally utilized in folk medicine. Several studies have determined some qualities of the plant extract, in the context of antioxidant or antimicrobial competence, while others have focused on its inhibitory assets against inflammation [59][60][61][62]. Three studies that took place over the past four years have assessed the potential of the plant in the context of experimental models [63][64][65].…”

Section: Mistletoe Fig (Ficus Deltoidea)mentioning

confidence: 99%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

View full text Add to dashboard Cite

The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.

show abstract

Antiangiogenic Effect of Ficus deltoidea Jack Standardised Leaf Extracts

Cited by 14 publications

References 15 publications

The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves

The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves

Ficus deltoidea: Review on Background and Recent Pharmacological Potential

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

Contact Info

Product

Resources

About