Antiangiogenic Effect of Flavonoids and Chalcones: An Update

Abstract

Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are intensively investigated because of a large spectrum of their biological activities. Among others, anticancer and antiangiogenic effects account for the research interest of these substances. Because of an essential role in cancer growth and metastasis, angiogenesis is considered to be a promising target for cancer treatment. Currently used antiangiogenic agents are either synthetic compounds or monoclonal antibodies. However, there are some limitations of their use including toxicity and high price, making the search for new antiangiogenic compounds very attractive. Nowadays it is well known that several natural compounds may modulate basic steps in angiogenesis. A lot of studies, also from our lab, showed that phytochemicals, including polyphenols, are potent modulators of angiogenesis. This review paper is focused on the antiangiogenic effect of flavonoids and chalcones and discusses possible underlying cellular and molecular mechanisms.

The Effects of Trifolium pratense L. Sprouts’ Phenolic Compounds on Cell Growth and Migration of MDA-MB-231, MCF-7 and HUVEC Cells

“…As it is shown in the Figure 10, significant decreases of VEGF protein and mRNA levels (10-20%) were observed only after MDA-MB-231 cells incubation with CUH and CUFH. Because VEGF stimulates membrane kinase receptor VEGFR2 following endothelial cells activation, diminished VEGF levels in the cellular environment and disruption of VEGF-related cell signaling may result in decreased proliferation, migration and tube formation [62]. In the case of MCF-7 cells, T. pratense phytocompounds showed almost a lack of influence in this field, yet still revealed chemoprevention of breast cancer cells.…”

Effects of Securigera Securidaca Seed Extract, Alone and in combination with Glibenclamide, on Circulating Levels of Pro-Angiogenic/Anti-Angiogenic Biomarkers in Hyperglycemic Rats

“…Administration of HESS did not show a protective effect in preventing an increase in serum VEGF concentration and a decrease in its soluble receptors, FLK-1 and sFLT-1 in diabetic rats. While HESS is rich in phenolic and avonoid compounds (93.3±1.5 mg GAE/g (DW) and 46 ± 1.7 mg QE /g (DW), respectively)(8), these ndings are inconsistent with the results of some studies that have stated that polyphenolic compounds downregulate the expression of angiogenic factors as an index of neovascularization (25,26). Park et al reported that polyphenols prevented the hypoxia-induced angiogenesis by reducing HIF-α transcriptional activity without altering its mRNA level, leading to reduce the expression of HIF-α downstream targets, including VEGF (27).…”

Preliminary updating on structural and chemotaxonomical aspects of pharmacologically evaluated flavonoids

“…Materials and Methods. Structure-Structure, structure-plant family and structure-activity trends were analyzed from 285 pharmacologically evaluated flavonoids belonging to different aglycone families and originated from different plant taxa (Mirossay et al, 2018;Cirmi et al, 2016;Panche et al, 2016;Xiao, 2015;Lago et al, 2014;Kumar et Pandey, 2013;Semmar, 2010). Nonparametric comparison and link tests as well as multivariate analyses were applied to highlight/detect such trends (Semmar, 2011(Semmar, , 2013.…”