Antiangiogenics in Choroidal Neovascularization Associated With Laser in Central Serous Chorioretinopathy

Abstract

Antivascular endothelial growth factor therapy appears to be safe and efficacious in CNVs secondary to laser photocoagulation and PDT. Choroidal neovascularizations secondary to PDT appear to be more resistant to antivascular endothelial growth factor therapy than those because of laser photocoagulation and required additional PDT.

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

“…The repairing mechanisms of surviving endothelial cells and the recanalization processes of novel 9 channels within previously occluded capillaries after PDT treatment remains unclear 1 . In addition to the possibility that CC flow recovered from the released pressure of decreased SFCT owing to the therapeutic effect of PDT 2,11 , one could speculate that the damaged choroidal endothelial cells and RPE cells in PDT-treated areas may contribute to the release of VEGF 24,25 , and an imbalanced stimulatory and inhibitory condition for neovascularization formation could be compromised by PDTrelated hypoxia and ischemia 25,26 . However, the process of recanalization could, to some extent, contribute to the formation of CNV 26 .…”

“…5) appearance of type I CNV, consisting with the morphologic characteristics of neovascularization networks within CC level on previous OCTA-related studies 20,27,28 . However, it is controversial that these suspected secondary CNV within CC level may contribute to the CC atrophy and the anterior displacement of medium-sized choroidal vessels with segmentation artifacts that masquerade as CNV 24 . Besides, type I CNV has been well documented as the most common subtype of secondary CNV in the natural course of CSC 1,6,29 , which should also be taken into account while studying PDT-related CNV 30 .…”

Intravitreal Ziv-Aflibercept in Treatment of Naïve Chronic Central Serous Chorioretinopathy Related Choroidal Neovascular Membrane

“…Apart from diabetic macular edema and AMD related CNVM, it has been used for treatment of polypoidal choroidal vasculopathy (PCV) and RPE detachment. Aflibercept (Eylea) has been used to treat CNVM secondary to laser/PDT in CSCR [ 8 ]. PDT has been used in treatment of CNVM secondary to idiopathic CSCR.…”

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

“…The repairing mechanisms of surviving endothelial cells and the recanalization processes of novel 10 channels within previously occluded capillaries after PDT treatment remains unclear 1 . In addition to the possibility that CC flow recovered from the released pressure of decreased SFCT owing to the therapeutic effect of PDT 2,11 , one could speculate that the damaged choroidal endothelial cells and RPE cells in PDT-treated areas may contribute to the release of VEGF 24,25 , and an imbalanced stimulatory and inhibitory condition for neovascularization formation could be compromised by PDTrelated hypoxia and ischemia 25,26 . However, the process of recanalization could, to some extent, contribute to the formation of CNV 26 .…”

“…5) appearance of type I CNV, consisting with the morphologic characteristics of neovascularization networks within CC level on previous OCTA-related studies 20,27,28 . However, it is controversial that these suspected secondary CNV within CC level may contribute to the CC atrophy and the anterior displacement of medium-sized choroidal vessels with segmentation artifacts that masquerade as CNV 24 . Besides, type I CNV has been well documented as the most common subtype of secondary CNV in the natural course of CSC 1,6,29 , which should also be taken into account when studying PDT-related CNV 30 .…”