Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice

Sousa, Francisca Cléa Florenço de; Melo, Cristina Carvalho de; Monteiro, Andreisa Paiva; Lima, Vera Targino Moreira; Gutierrez, Stanley Juan Chaves; Pereira, Bruno A.; Barbosa-Filho, José Maria; Vasconcelos, Silvânia Maria Mendes; Fonteles, M.F; Viana, G. S. B.

doi:10.1016/j.pbb.2004.01.019

Cited by 75 publications

(73 citation statements)

References 19 publications

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“…Brazil not only has one of the world's highest levels of biodiversity but also it has a wealth of traditional knowledge accumulated by local people who have direct access to nature and to the products of biodiversity (Albuquerque et al, 2007). In this sense, information from Brazilian ethnic groups on traditional medicine have contributed to the discovery of pharmacological activities from several plant-derived agents, which have resulted in a signifi cant body of publications (Almeida et al, 2001;Sousa et al, 2004a;2005;De Sousa et al, 2006;Amaral et al, 2007;Silva et al, 2007;Volpato et al, 2008;Silva et al, 2009a;Silva et al 2009b;Morais at al., 2010). In spite of this, the current knowledge on the biodiversity of ecosystems as, for example, of the northeast region, is still very embryonic.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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Section: Introductionmentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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“…That possibly explains the difference in doses for the AE on the two models of depression. Support for this hypothesis was found in the work of Sousa et al (2004) where the tryciclic antidepressant imipramine decreased the immobility time in the tail supension test at a higher dose (30 mg/kg) when compared with the effect…”

Section: Discussionmentioning

confidence: 71%

“…Repeated restraint stress was shown to increase the frequency of grooming and desipramine reversed this effect (D'Aquila et al, 2000). Moreover, Sousa et al (2004) described antianxiety and antidepressive effects of riparin III, a tyramine analogue isolated from Aniba riparia. In the open fi eld test, riparin III (25 and 50 mg/kg) decreased the number of groomings and the immobility time in the forced swimming model.Therefore, it seems that grooming behavior in the open fi eld can be a predictor for antidepressant activity, possibly via the dopaminergic mesolimbic system (D'Aquila et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of the aqueous extract from Hyptis pectinata leaves on rodent central nervous system

Bueno¹,

Moreira²,

Silva³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: "Efeitos do extrato aquoso das folhas da Hyptis pectinata sobre o sistema nervoso central de roedores". Neste trabalho foram estudados os efeitos do extrato aquoso (EA) obtido das folhas da Hyptis pectinata sobre o sistema nervoso central de roedores. Os seguintes modelos experimentais foram utilizados em camundongos, machos e fêmeas, da linhagem Wistar: "screening" farmacológico, campo aberto, nado forçado, hipotermia induzida por apomorfi na, labirinto em cruz elevado e tempo de sono induzido por tiopental. O extrato foi administrado por via oral em dose única, 30 minutos antes de cada teste. No "screening" farmacológico o EA (400 mg/kg, p.o., n = 3) diminuiu a freqüência do comportamento de auto-limpeza. No teste do campo aberto o EA diminuiu o tempo gasto em auto-limpeza (AE400: 51,3 ± 8,8, q = 5,513, P < 0.01, n = 10) de maneira similar ao diazepam (control: 107,3 ± 14,2; diazepam: 15,4 ± 4,3, q = 9,049, P < 0.001, n = 10). No teste do nado forçado o EA (400 mg/kg) diminuiu o tempo de imobilidade (con: 181,3 ± 7,2 s; imip: 91,6 ± 8,9 s, q = 7,958, P < 0,001; AE400: 111,6 ± 14,5 s, q = 6,193, P < 0,001, n = 9) indicando um possível efeito antidepressivo. Isto foi confi rmado no modelo de hipotermia induzida pela apomorfi na onde o EA (200 mg/kg) antagonizou o efeito da apomorfi na (AE200: -0,27 o C, q = 5,588, P < 0,001, n = 10) de maneira similar à imipramina (5 mg/kg) (control: -1,08 o C; imipramine: 0,02 o C, q = 7,589, P < 0,001, n = 10). Nenhum efeito do EA foi observado nos testes do labirinto em cruz elevado e do tempo de sono induzido por tiopental. Nossos resultados sugerem um possível efeito antidepressivo do extrato aquoso obtido das folhas da Hyptis pectinata. Unitermos:Hyptis pectinata, Lamiaceae, plantas medicinais, depressão. ABSTRACT:The effects of the aqueous extract (AE) from Hyptis pectinata leaves was studied on rodent central nervous system (CNS). Pharmacological screening, open fi eld, forced swimming, apomorphine-induced hypothermia, elevated plus maze and thiopental-induced sleep tests were used in male and female Swiss mice and Wistar rats. The AE was admnistered orally in single doses 30 minutes before each test. In the screening test the AE (400 mg/kg, p.o., n =3) decreased the frequency of grooming behavior. In the open fi eld test it decreased the amount of time rats spent grooming (AE400: 51.3 ± 8.8, q = 5.513, P < 0.01, n = 10), similarly to diazepam (control: 107.3 ± 14.2; diazepam: 15.4 ± 4.3, q = 9.049, P < 0.001, n = 10). In the forced swimming test the AE (400 mg/kg) decreased the immobility time (con: 181.3 ± 7.2 s; imip: 91.6 ± 8.9 s, q = 7.958, P < 0.001; AE400: 111.6 ± 14.5 s, q = 6.193, P < 0.001, n = 9), indicating a possible antidepressive effect. This was confi rmed in the apomorphine-induced hypothermia model where the extract (200 mg/kg) antagonized the apomorphine effect (AE200: -0.27 o C, q = 5.588, P < 0.001, n = 10), similarly to imipramine (imipramine: 5 mg/kg) (control: -1.08 o C; imipramine: 0.02 o C, q = 7.589, P < 0.001, n = 10). No effect of the...

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“…Therefore, it is probable that these effects are not related to the stimulation of general motor activity. [35] The fear due to height induces anxiety in the animals when placed on the EPM. The ultimate manifestation of anxiety and fear in the animals is exhibited by decrease in the motor activity and preference to remain at safer places.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

Murthy¹

2017

WJPR

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Tephrosia pumila (L.) Pers (Leguminosae (Fabaceae)), is an herbaceous climber that has been generally utilized in Indian traditional medicine for the treatment of different central nervous system (CNS) disorders. Nevertheless, the available scientific information about this species is rare and there are no reports identified with its conceivable impact on the CNS. In this work, the effects of ethanolic extract of Tephrosia pumila (L.) Pers (TPP) were assessed in rats utilizing behavioral tests sensitive to clinically effective antidepressant and anxiolytic effects compounds. The extract (200 and 400mg/kg), administered intraperitoneally, was able to decrease the immobility time of rats dose-dependently when subjected to both tail suspension and forced swim tests for antidepressant activity and elevated Pluse maze test, actophotometer test for anxiolytic effect and the effects are comparable to that of standard drugs i.e., Diazepam (20mg/kg). Neither the extracts of TPP and Diazepam, at the doses tested, produced significant effects on locomotor activity when subjected to open field behavioral test. These results demonstrated that TPP had specifically antidepressant effects in vivo. In conclusion, the present study recommended that TPP extracts possessed potential antidepressant and anxiolytic effects which could be of therapeutic interest for using in the treatment of patients with depressive disorders.

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Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice

Cited by 75 publications

References 19 publications

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Effects of the aqueous extract from Hyptis pectinata leaves on rodent central nervous system

Antidepressant and Anxiolytic Effects of Alcoholic Extract From Tephrosia Pumila (L.) Pers

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