Antiarrhythmic activity of the total alkaloids from aRauwolfia serpentina tissue culture

Antihypertensive and Antihyperlipidemic Activity of Aqueous Methanolic Extract of Rauwolfia Serpentina in Albino Rats

“…2,7 It is utilized in the management of hypertension, arrhythmia, human promyelocytic leukemia, pneumonia, asthma, AIDS, spleen disorders, and skin illnesses. 6,8,9 The present study was planned to evaluate the R serpentina therapeutic potential in the treatment of hypertension and hypercholesterolemia induced in animal model.…”

Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry

“…Rauvolfia species (Apocynaceae) are important medicinal plants which are commonly used in different traditional medical systems (Monachino, 1954). They are identified for the treatment of high blood pressure (Bhatia, 1942;Vakil, 1955;Achor et al, 1955), arrhythmia (Arora and Madan, 1956;Kostin et al, 1990), various mental disorders (Kline, 1954), fever (malaria) (Zirihi et al, 2005), microbial (Shariff et al, 2006;Suresh et al, 2008), intestinal and spleen ailments (Yu et al, 2013), oxidative stress (Harisaranraj et al, 2009;Gupta et al, 2015) and cancer (Yu et al, 2013). The important species include Rauvolfia serpentina, R. tetraphylla, R. hookeri, R. micrantha, R. verticillata, R. vomitoria and R. canescens widely distributed in Asia, Africa and America (Monachino, 1954;Bindu et al, 2014).…”

Press for MIA production! The role of the Rho of plant GTPases in plant-specialized metabolism

“…The tropical plant Catharanthus roseus , commonly known as Madagascar Periwinkle, is highly appreciated not only for its ornamental beauty but also for being a source of specialized metabolites with therapeutic properties called monoterpene indole alkaloids (MIA). Some examples include anticancer compounds, vinblastine and vincristine ( Dhyani et al 2022 ), or ajmalicine and serpentine, which are used in the treatment of hypertension ( Kostin et al 1986 ). The biosynthesis of MIAs is a highly intricate process involving over 50 enzymes from various pathways, transcription factors (TFs), intra-/intercellular signaling molecules, and transporters ( Pan et al 2016 ).…”