Antiarrhythmic effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion injury in rats

Huang, Shiang‐Suo; Liu, Shengming; Lin, Su-Man; Liao, Pei-Hu; Lin, Ruey-Hseng; Chen, Yu‐Chia; Chih, Chun-Lien; Tsai, Shen‐Kou

doi:10.1016/j.clinbiochem.2005.07.003

Cited by 22 publications

(11 citation statements)

References 27 publications

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“…6, 44 Luteolin is believed to be an antioxidant or a free radical scavenger in the biological system. 21- 23 In support of this contention, we found that levels of MDA, a lipid peroxidation product regarded as a presumptive marker for oxidative stress, were decreased in heart tissue after IR injury in rats administered luteolin. We suggest that the mass production of oxygen-derived free radicals during myocardial IR may be arrested by the antioxidant activity of luteolin.…”

Section: Cardioprotective Effects Of Luteolinsupporting

confidence: 65%

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Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

Liao

Hung

Chen

et al. 2011

Circ J

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Section: Cardioprotective Effects Of Luteolinsupporting

confidence: 65%

“…23 Briefly, the rats were anesthetized with intraperitoneal urethane (1.25 g/kg) and placed on an operating table. The trachea was cannulated for artificial respiration and the jugular vein was cannulated for drug administration.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

Liao

Hung

Chen

et al. 2011

Circ J

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“…Temporary occlusion of the left main coronary artery was carried out to induce myocardial IR injury, as previously described (Huang et al, 2005). Briefly, urethane was used to anesthetize the rats (1.25 g/kg, i.p.).…”

Section: Methodsmentioning

confidence: 99%

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

Su¹,

Chu

Liao

et al. 2017

Front. Pharmacol.

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The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease is a major contributor to global morbidity and mortality. It is known that regulation of programmed cell death including apoptosis and autophagy reduces the impact of myocardial IR injury. In this study, the cardioprotective effects and underlying mechanisms of Phellinus linteus (Berk. and Curt.) Teng, Hymenochaetaceae (PL), a type of medicinal mushroom, were examined in rats subjected to myocardial IR injury. The left main coronary artery of rats was ligated for 1 h and reperfused for 3 h. The arrhythmia levels were monitored during the entire process and the infarct size was evaluated after myocardial IR injury. Furthermore, the expression levels of proteins in apoptotic and autophagic pathways were observed. Pretreatment with PL mycelium (PLM) significantly reduced ventricular arrhythmia and mortality due to myocardial IR injury. PLM also significantly decreased myocardial infarct size and plasma lactate dehydrogenase level after myocardial IR injury. Moreover, PLM administration resulted in decreased caspase 3 and caspase 9 activation and increased Bcl-2/Bax ratio. Phosphorylation level of AMPK was elevated while mTOR level was reduced. Becline-1 and p62 levels decreased. These findings suggest that PLM is effective in protecting the myocardium against IR injury. The mechanism involves mediation through suppressed pro-apoptotic signaling and regulation of autophagic signaling, including stimulation of AMPK-dependent pathway and inhibition of beclin-1-dependent pathway, resulting in enhancement of protective autophagy and inhibition of excessive autophagy.

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“…Myocardial ischemia reperfusion (IR) injury was induced by ligation of left anterior descending coronary artery described previously [24]. Briefly, the rats were anesthetized intraperitoneally with pentobarbitone sodium (60 mg/kg) and placed on an operating table.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Protective effects of bifunctional platelet GPIIIa49-66 ligand on myocardial ischemia-reperfusion injury in rats

Fan¹,

Jing²,

Dang³

et al. 2013

Health

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Current antiplatelet drugs mainly focus on prevention rather than the more clinically relevant issue of clearance of an existing thrombus. We recently described a novel and effective therapeutic strategy for dissolution of preexisting platelet thrombus in a murine ischemic stroke model with a bifunctional platelet GPIIIa49-66 ligand (Single-chain antibody Linked first Kringle 1 of plasminogen, named SLK), which homes to newly deposited fibrin strands tangled of platelet thrombus and induces aggregated platelet fragmentation. In this study, we perform in-depth analysis of the effect of SLK on myocardial ischemia-reperfusion (IR) injury in rats. We show that SLK dose-dependently reduces lactate dehydrogenase (LDH) release as well as mean infarction size of left ventricle. Histological observation demonstrates that the arterial thrombi in coronary arteries of rat almost disappear after SLK injection. Optimal dose of SLK (37.5 μg/ individual) provides the myocardial protection at 2 hours post-infusion. However, there are no significant protective effects if SLK was given at 4 or 8 hours post-infusion. The combined application of SLK and urokinase (UK) demonstrates greater myocardial protection than UK alone at 2 hours post-infusion. Thus, SLK could be used as a thrombolytic alternative in other arterial vascular beds associated with thrombosis to enhance fibrinolysis.

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Antiarrhythmic effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion injury in rats

Cited by 22 publications

References 27 publications

Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

Cardioprotective Effects of Luteolin During Ischemia-Reperfusion Injury in Rats

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation

Protective effects of bifunctional platelet GPIIIa49-66 ligand on myocardial ischemia-reperfusion injury in rats

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