Antiarrhythmic Effects of Statins in Heart Failure

Sandesara, Chirag; Roodneshin, Hamid; Sbaity, Salam; Olshansky, Brian

doi:10.1016/j.hfc.2008.01.008

Cited by 2 publications

(2 citation statements)

References 93 publications

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“…While beta-blocker use affects heart rate and the occurrence of ICD shocks, there was no difference in beta-blocker therapy between persons with and without diabetes. Statin use, common in a population of persons with diabetes, may have had an antiarrhythmic effect [16].…”

Section: Discussionmentioning

confidence: 99%

Older Persons with Diabetes Receive Fewer Inappropriate ICD Shocks: Results from the INTRINSIC RV Trial

Sandesara

Sullivan

Russo

et al. 2010

J. of Cardiovasc. Trans. Res.

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In patients with heart disease, diabetes and age predict adverse outcomes. It remains unclear whether persons with diabetes who have implantable cardioverter defibrillators (ICDs) have fewer appropriate and inappropriate ICD shocks. The objective of this study is to determine if persons with diabetes who have ICDs receive a similar amount of appropriate and inappropriate shocks compared to persons without diabetes. In a post hoc analysis of 1,528 patients enrolled in the INTRINSIC RV trial, all-cause mortality and ICD shocks between persons with and without diabetes, stratified by age, was compared. The relationship between shock and mortality was also assessed. Mortality 1 year after ICD implant was lower for persons without diabetes vs. persons with diabetes (3.5% vs. 7.9%, p < 0.001). Young and old persons with diabetes received a similar number of total and appropriate ICD shocks. However, older persons with diabetes were less likely to receive inappropriate ICD shocks vs. older persons without diabetes (1.9% vs. 6.9%, p < 0.01). ICD shocks were not temporally related to mortality regardless of diabetes status. In the INTRINSIC RV trial, persons with diabetes and older persons without diabetes undergoing ICD implant were at a higher risk of death. Older persons with diabetes received less inappropriate shocks and still had a similar amount of appropriate shocks compared to persons without diabetes of similar age.

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Section: Discussionmentioning

confidence: 99%

Older Persons with Diabetes Receive Fewer Inappropriate ICD Shocks: Results from the INTRINSIC RV Trial

Sandesara

Sullivan

Russo

et al. 2010

J. of Cardiovasc. Trans. Res.

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“…Importantly, lipid-altering strategies such as statin drugs or dietary supplementation with n-3 polyunsaturated fatty acids have shown promise as anti-arrhythmic therapy. These interventions are believed to exert effects via several mechanisms including modulation of ion channel expression and function [122-124]. The antiarrhythmic action of polyunsaturated fatty acids such as eicosapentaenoic acid has been partially attributed to a decrease in I Ca,L [122,125].…”

Section: Subcellular Localization Impacts Ltcc Functionmentioning

confidence: 99%

Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes

Best

Kamp

2012

Journal of Molecular and Cellular Cardiology

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Influx of Ca2+ through L-type Ca2+ channels (LTCCs) contributes to numerous cellular processes in cardiomyocytes including excitation-contraction (EC) coupling, membrane excitability, and transcriptional regulation. Distinct subpopulations of LTCCs have been identified in cardiac myocytes, including those at dyadic junctions and within different plasma membrane microdomains such as lipid rafts and caveolae. These subpopulations of LTCCs exhibit regionally distinct functional properties and regulation, affording precise spatiotemporal modulation of L-type Ca2+ current (ICa,L). Different subcellular LTCC populations demonstrate variable rates of Ca2+-dependent inactivation and sometimes coupled gating of neighboring channels, which can lead to focal, persistent ICa,L. In addition, the assembly of spatially defined macromolecular signaling complexes permits compartmentalized regulation of ICa,L by a variety of neurohormonal pathways. For example, β-adrenergic receptor subtypes signal to different LTCC subpopulations, with β2-adrenergic activation leading to enhanced ICa,L through caveolar LTCCs and β1-adrenergic stimulation modulating LTCCs outside of caveolae. Disruptions in the normal subcellular targeting of LTCCs and associated signaling proteins may contribute to the pathophysiology of a variety of cardiac diseases including heart failure and certain arrhythmias. Further identifying the characteristic functional properties and array of regulatory molecules associated with specific LTCC subpopulations will provide a mechanistic framework to understand how LTCCs contribute to diverse cellular processes in normal and diseased myocardium.

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Antiarrhythmic Effects of Statins in Heart Failure

Cited by 2 publications

References 93 publications

Older Persons with Diabetes Receive Fewer Inappropriate ICD Shocks: Results from the INTRINSIC RV Trial

Older Persons with Diabetes Receive Fewer Inappropriate ICD Shocks: Results from the INTRINSIC RV Trial

Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes

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