Antiarrhythmic profile of a new class 1 drug, AHR 10718, on canine atrial and ventricular arrhythmia models.

Abstract

Abstract-Antiarrhythmic

Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: Which electrophysiological characteristics of drugs are related to their effectiveness?

“…As reported earlier [1,2,[5][6][7][8][9][11][12][13][14][15][16][17][18]20,21,[23][24][25][26][27][28][29][30][31][32], mongrel and beagle dogs of either sex, as well as female beagle dogs, weighing about 7-15 kg, were anesthetized initially with thiopental sodium. After intubation, 1.0% halothane, vaporized with 100% oxygen, was administered with a volume-limited ventilator (20 ml/kg, 15 strokes/min).…”

“…AHR 10718 is an investigational class I antiarrhythmic drug and was effective on digitalis and coronary ligation arrhythmias, but was not effective on adrenaline arrhythmia [20], and the recalculated ICs0s for digitalis, 24-hour coronary ligation, and adrenaline arrhythmias were 3.8 (3.0-5.9; n = 31, r = -0.57, p < 0.01), 9.0 (5.8-30; n = 22, r = -0.51, p < 0.05), and 18.9 (13.3-60; n = 20, r = -0.52, p < 0.05) ~g/ ml. AN-132 is also an investigational class I antiarrhythmic drug and was effective on digitalis and coronary ligation arrhythmias, but was not effective on adrenaline arrhythmia [28], and the recalculated ICs0s for digitalis, 24-hour coronary ligation, and adrenaline arrhythmias were 1.6 (1.0-4.3; n = 22, r = -0.52, p < 0.05), 8.3 (4.3-~; n = 30, r = -0.38, p < 0.05), and 10.6 (8.0-19.5; n = 28, r = -0.41, p < 0.01) ~g/ml.…”

“…For intravenous infusion studies, a constant-rate infusion was performed for 10 minutes using a syringe pump, and arterial blood samples were drawn from one lumen of the arterial double-lumen cannula at 0, 1, 3,5,7,9,13,15,30, and 60 minutes after the start of the infusion. [6][7][8]12,14,17,18,[20][21][22][23][24][25][26][27][28][29][30][31][32], female beagle dogs, weighing about 7-12 kg, were anesthetized initially with intravenous thiopental sodium, 30 mg/kg, and intubated. The chest was opened and a two-stage coronary ligation of the left anterior descending artery (LAD) was performed under halothane anesthesia.…”