Antiasthmatic effect of Nigella sativa in airways of asthmatic patients

Boskabady, Mohammad Hossein; Mohsenpoor, N.; Takaloo, L.

doi:10.1016/j.phymed.2010.01.002

Cited by 159 publications

(108 citation statements)

References 13 publications

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“…The results of the this study showed that N. sativa has a relatively potent antiasthmatic effect on asthmatic airways. However, the effects of boiled extract of this plant on most measured PFTs were less than those of theophylline at concentrations used [8] .…”

Section: +mentioning

confidence: 75%

“…Khan et al in 2003 reported that the aqueous extract of N. sativa seeds exhibits inhibitory effect against candidiasis in mice. A 5-fold decrease in Candida in kidneys, 8-fold in liver and 11-fold in spleen was observed in the groups of animals post-treated with the plant extract. These findings were also confirmed by Histopathological examination of the respective organs [30] .…”

Section: Antifungal Activitymentioning

confidence: 88%

“…TQ was found to increase sub-G1 accumulation and annexin-V positive staining, indicating apoptotic induction. In addition, TQ activated caspases 8,9 and 7 in a dose-dependent manner. Migration and invasive properties of MDA-MB-231 cells were also reduced in the presence of TQ.…”

Section: Anticancer Activitymentioning

confidence: 94%

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A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,117

796

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Section: +mentioning

confidence: 75%

Section: Antifungal Activitymentioning

confidence: 88%

See 1 more Smart Citation

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,117

796

View full text Add to dashboard Cite

“…Other medical effects like: Antiasthmatic (M.H. Boskabady, et al 2010), protective toxicity (Ahmed M. Mohamadin et al 2010), plasma antioxidant capacity (Maznah Ismail et al 2010, Mahmoud et al, 2015, antifungal (Eugene A. Rogozhin et al 2010), anti-nephrotoxicity (İhsan and Engin 2010), antiallergic (Soheila et al 2010, retards the progression of atherosclerosis (Mohammad and Hedi, 2010) and many other diseases (G. Lupidi, et al 2010, Osama andSoliman, 2010) were cited.…”

Section: Introductionmentioning

confidence: 99%

Light, Salinity and Temperature Effects on the Seed Germination of Nigella Sativa L.

Alshammari¹

2017

GJBAHS

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This work was carried out in the laboratory of Botany in the College of Sciences in the University of Hail, Saudi Arabia. It deals with the germination conditions of Nigella sativa, used for medicinal purposes for centuries, both as an herb and pressed into oil, in Asia, Middle East and Africa.The germination requirements Nigella sativa, were studied under control conditions in the laboratory. Treatments included four light levels (0 :24) ; (6: 18) ; (12 : 12) then 24 :0) hour ( light : dark) period, six salinity concentrations (0, 2, 4, 6, 8, and 10 gl/L NaCl), and four temperature regimes (15°, 17°, 20° and 25°), using a completely randomized block design.This work shows that germination of Nigella sativa was very sensible to temperature with an optimum of 23°C. Germination will stop below 15°C and after 25°C. For salinity the best seed germination of all experiments was obtained in a distilled water control. The progressive increase in salinity, until 8g/l, have no significant effect on germination. The inhibition of germination was significant only after 10g/l. The absence of light give the best rate of germination that would be lower if light period increase and it will be inhibited completely at 18h of light regime. In this work optimal conditions for germination of Nigella sativa were determined.

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“…In fact, literature is replete with the subject of pharmacological actions of a single component or an extract of Nigella sativa seeds [8]. These multi-dimensional, "nutraceutical" actions include analgesic [9] antimicrobial [10,11], antidiabetic [12], anti-hypertensive [13,14], antihistaminic [15,16], immunopotentiating [17,18], anti-inflammatory [19][20][21], antioxidant and radical scavenging actions [22][23][24]. The antineoplastic effects of N. sativa seed and its extracts were investigated both in vivo using animal models and in vitro using cancer cell lines [25].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of <i>Nigella sativa</i> Seeds Lacks the Chemopreventive Efficacy in the Post Initiation Phase of DMH-Induced Colon Cancer in a Rat Model

Asfour¹,

Almadi²,

Haffar³

2013

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Nigella sativa, belonging to the Ranunculacea family, is a versatile phytochemical mine bestowed with multi-dimensional medicinal effects. The current study was performed to investigate the chemopreventive efficacy, if any, of the ethanolic extract of indigenous Nigella sativa seeds (ENS) and to evaluate its potentials on tumor progression during the initiation and post initiation phases of Dimethylhydrazine-induced colon carcinogenesis in a rat model. ENS treatment during the initiation phase unveiled chemopreventive effect manifested by significant reductions in tumor incidence, multiplicity and tumor volumes. Histopathological findings and modified Duke's classification of tumors provided evidence that ENS, administered in the initiation phase, is capable of delaying progression, restricting invasion and attenuating aggressiveness of colon tumors. These results imply that ENS may be a promising candidate in the primary prevention of colon cancer. On the contrary, we demonstrated that ENS lacked chemopreventive and tumorigenesis inhibitory effects in the post initiation phase. We speculate that the chemopreventive effect of ENS might be due to the synergistic actions of various constituents present in the extract. However, extensive studies are warranted and more efforts need to be dedicated to fractionate, analyze and to further appraise the anticancer effect of ENS before any definitive conclusions can be drawn.

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Antiasthmatic effect of Nigella sativa in airways of asthmatic patients

Cited by 159 publications

References 13 publications

A review on therapeutic potential of Nigella sativa: A miracle herb

A review on therapeutic potential of Nigella sativa: A miracle herb

Light, Salinity and Temperature Effects on the Seed Germination of Nigella Sativa L.

Ethanolic Extract of <i>Nigella sativa</i> Seeds Lacks the Chemopreventive Efficacy in the Post Initiation Phase of DMH-Induced Colon Cancer in a Rat Model

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Antiasthmatic effect of Nigella sativa in airways of asthmatic patients

Cited by 159 publications

References 13 publications

A review on therapeutic potential of Nigella sativa: A miracle herb

A review on therapeutic potential of Nigella sativa: A miracle herb

Light, Salinity and Temperature Effects on the Seed Germination of Nigella Sativa L.

Ethanolic Extract of &lt;i&gt;Nigella sativa&lt;/i&gt; Seeds Lacks the Chemopreventive Efficacy in the Post Initiation Phase of DMH-Induced Colon Cancer in a Rat Model

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Ethanolic Extract of <i>Nigella sativa</i> Seeds Lacks the Chemopreventive Efficacy in the Post Initiation Phase of DMH-Induced Colon Cancer in a Rat Model