Antiasthmatic effects of schizandrae fructus extract in mice with asthma

Abstract

Background:Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea.Objective:Investigation of the antiasthmatic effects of SF.Materials and Methods:We investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen-specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen.Results:SF lowered AHR to methacholine (P < 0.05), antigen-specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen-specific IgG1 and IgG2a antibodies.Conclusion:Our data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

“…The results also suggest that the fruit extracts could be used as a complementary or alternative medicine to glucocorticoids (Kim et al 2014a). …”

Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway

“…Nine major bioactive ingredients within S. chinensis were identified, including schisandrol A, schisandrol B, angeloylgomisin H, gomisin G, schisantherin A, schisanhenol, schisandrin A, schisandrin B, and schisandrin C16. Current reports demonstrated that these ingredients of S. chinensis possess several biological activities, such as antioxidant, antitumor, anti-inflammatory, and immunoregulatory activities15181920212223, and schisandrin A and schisandrin B exhibit antiviral activity against HIV24. Here, we investigated whether schisandrin A, schisandrin B, or schisandrin C could exhibit anti-DENV activity in vitro and in vivo and further investigated the molecular mechanism by which the effective ingredient inhibits DENV replication.…”

Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice

“…Deoxyschizandrin has been shown to be associated with a variety of diseases such as chronic cough,[18] hepatoprotective,[19] and cardiovascular disease. [20] It has also been reported that deoxyschizandrin have diverse effects, such as anti-proliferative effects on tumor cells and pretreatment on physical exercise-induced muscle damage.…”