Antibacterial action of Chlorhexidine/thymol containing varnishes <i>in vitro</i> and <i>in vivo</i>

Hf, Jentsch; Fr, Eckert; Eschrich, Klaus; Stratul, Ştefan‐Ioan; Kneist, S

doi:10.1111/idh.12079

Cited by 10 publications

(11 citation statements)

References 18 publications

(15 reference statements)

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“…At a closer look to the statistically significant differences between the test and the control groups, one can remark that the differences in the detectability/non‐detectability of some of the tested periopathogens affected only one and two patients in each group, respectively, and thus, it should not be overestimated. In general, the results are similar to findings comparing two CHX varnishes .…”

Section: Discussionsupporting

confidence: 85%

Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water‐soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial

Rusu

Stratul

et al. 2015

Int J Dental Hygiene

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Section: Discussionsupporting

confidence: 85%

Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water‐soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial

Rusu

Stratul

et al. 2015

Int J Dental Hygiene

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“…Although QAMS exhibits broad-spectrum antimicrobial activities against single-species bacterial and fungal biofilms in vitro , the in vivo sensitivity of biofilms to antimicrobial agents against device-related infections may not be as effective as that in vitro 44 . Moreover, some microbial strains may be more sensitive to antimicrobial agents than others 45 . This species diversity exists in vivo but not in multi-species biofilms cultured in vitro .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial

Liu

Tonggu

Niu

et al. 2016

Sci Rep

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Quaternary ammonium methacryloxy silicate (QAMS)-containing acrylic resin demonstrated contact-killing antimicrobial ability in vitro after three months of water storage. The objective of the present double-blind randomised clinical trial was to determine the in vivo antimicrobial efficacy of QAMS-containing orthodontic acrylic by using custom-made removable retainers that were worn intraorally by 32 human subjects to create 48-hour multi-species plaque biofilms, using a split-mouth study design. Two control QAMS-free acrylic disks were inserted into the wells on one side of an orthodontic retainer, and two experimental QAMS-containing acrylic disks were inserted into the wells on the other side of the same retainer. After 48 hours, the disks were retrieved and examined for microbial vitality using confocal laser scanning microscopy. No harm to the oral mucosa or systemic health occurred. In the absence of carry-across effect and allocation bias (disks inserted in the left or right side of retainer), significant difference was identified between the percentage kill in the biovolume of QAMS-free control disks (3.73 ± 2.11%) and QAMS-containing experimental disks (33.94 ± 23.88%) retrieved from the subjects (P ≤ 0.001). The results validated that the QAMS-containing acrylic exhibits favourable antimicrobial activity against plaque biofilms in vivo. The QAMS-containing acrylic may also be used for fabricating removable acrylic dentures.

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“…The evidence from this review was mixed and therefore inconclusive for CHX-V reducing caries risk. More recently, Jentsch et al found CHX-V significantly reduced MS counts in supragingival plaque (P < 0.05) (15).…”

Section: Introductionmentioning

confidence: 93%

“…More recently, Jentsch et al . found CHX‐V significantly reduced MS counts in supragingival plaque ( P < 0.05) .…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial effect of chlorhexidine varnish on mutans streptococci in patients with fixed orthodontic appliances: a systematic review of clinical efficacy

Tang

Sensat²,

Stoltenberg

2015

Int J Dental Hygiene

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A limited number of studies with low risk of bias were available to address the antimicrobial efficacy of CHX-V on MS in patients during orthodontic treatment with fixed appliances. Therefore, while the majority of studies found CHX-V to be an effective antimicrobial against MS at an interval of 3-4 weeks, the strength of the recommendation is weak. Longitudinal studies are needed to determine whether this antimicrobial effect will contribute to clinically significant caries reduction in patients undergoing orthodontic treatment with fixed appliances.

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Antibacterial action of Chlorhexidine/thymol containing varnishes in vitro and in vivo

Abstract: Both varnishes may influence the plaque formation and reduce mutans streptococci in supragingival plaque.

Cited by 10 publications

References 18 publications

Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water‐soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial

Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water‐soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial

Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: a randomised clinical trial

The antimicrobial effect of chlorhexidine varnish on mutans streptococci in patients with fixed orthodontic appliances: a systematic review of clinical efficacy

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