Antibacterial action of Tropical honey on various bacteria obtained from diabetic foot ulcer

Kateel, Ramya; Bhat, Ganesh; Baliga, Shrikala; Augustine, Alfred Joseph; Ullal, Sonali; Adhikari, Prabha

doi:10.1016/j.ctcp.2017.11.001

Cited by 18 publications

(10 citation statements)

References 19 publications

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“…Topical honey appears to be safe and is relatively inexpensive. Some studies have demonstrated antibacterial effects of honey on various microorganisms obtained from DFUs, either in vitro or in a wound, but there are no published studies clearly demonstrating efficacy against clinical findings of infection . In some populations, especially in low‐income countries, use of various home remedies for treating DFIs has been reported.…”

Section: Treatmentmentioning

confidence: 99%

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

548

729

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The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999. This guideline is on the diagnosis and treatment of foot infection in persons with diabetes and updates the 2015 IWGDF infection guideline. On the basis of patient, intervention, comparison, outcomes (PICOs) developed by the infection committee, in conjunction with internal and external reviewers and consultants, and on systematic reviews the committee conducted on the diagnosis of infection (new) and treatment of infection (updated from 2015), we offer 27 recommendations. These cover various aspects of diagnosing soft tissue and bone infection, including the classification scheme for diagnosing infection and its severity. Of note, we have updated this scheme for the first time since we developed it 15 years ago. We also review the microbiology of diabetic foot infections, including how to collect samples and to process them to identify causative pathogens. Finally, we discuss the approach to treating diabetic foot infections, including selecting appropriate empiric and definitive antimicrobial therapy for soft tissue and for bone infections, when and how to approach surgical treatment, and which adjunctive treatments we think are or are not useful for the infectious aspects of diabetic foot problems. For this version of the guideline, we also updated four tables and one figure from the 2016 guideline. We think that following the principles of diagnosing and treating diabetic foot infections outlined in this guideline can help clinicians to provide better care for these patients.

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Section: Treatmentmentioning

confidence: 99%

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

548

729

View full text Add to dashboard Cite

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“…For millennia, the medicinal properties of honey have been used by mankind. This popular bee product is versatile and is effective against microbes [1][2][3][4], reducing inflammation [5], combating cancer [6], hypertension [7], and liver disease [8], aids in wound healing [3,9] and provides cough relief [10]. An important therapeutic quality of honey is its antimicrobial activity [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Physical characteristics and antimicrobial properties of Apis mellifera, Frieseomelitta nigra and Melipona favosa bee honeys from apiaries in Trinidad and Tobago

Brown

O’Brien

Georges

et al. 2020

BMC Complement Med Ther

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Background: Honey is a versatile and complex substance consisting of bioactive chemicals which vary according to many bee and environmental factors. The aim of this study was to assess the physical and antimicrobial properties of five honey samples obtained from three species of bees; two stingless bees, Frieseomelitta nigra and Melipona favosa and one stinging bee, Apis mellifera (fresh and aged honey). Samples were acquired from apiaries across Trinidad and Tobago. An artificial honey, made from sugar, was also used for comparison. Methods: Physical properties such as appearance, pH, moisture content, sugar content and specific gravity were determined. Antimicrobial activity was assessed utilizing the agar diffusion assay and comparison to a phenol equivalence. The broth microdilution test was performed to determine the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the five honey samples against four common pathogens, including Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes and Haemophilus influenzae. Results: All honey samples were acidic, with pH values ranging from 2.88 (M. favosa of Tobago) to 3.91 (fresh A. mellifera). Sugar content ranged from 66.0 to 81.6% with the highest values detected in stinging bee honeys of the A. mellifera (81.6 and 80.5°Bx). Moisture content ranged from 16.9% for aged A. mellifera honey (from Trinidad) to 32.4% for F. nigra honey (from Tobago). The MICs (2 to 16%) and MBCs (2 to 32%) of stingless bee honeys were lower than that of stinging bee and artificial honeys (16 to > 32%). Stingless bee honeys also exhibited a broad spectrum of antimicrobial activity against both Gram-positive and Gram-negative organisms with higher phenol equivalence values (4.5 to 28.6%) than the A. mellifera honeys (0 to 3.4%) against the isolates tested. M. favosa honey of Tobago displayed the greatest antimicrobial activity as indicated by the high phenol equivalence and low MIC and MBC values. Conclusions: Stingless bee honeys from Tobago showed the greatest antimicrobial activity when compared to the other honeys used in this study. M. favosa honey of Tobago showed the most potential for use as medicinal honey.

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“…aureus, E. coli, P. aeruginosa, Proteus mirabilis, coagulase-negative Staphylococcus, Streptococcus pyogenes and K. pneumonia. Most studies focused on a wide range of geographical and botanical origins have been reported in Saudi Arabia (Ghramh et al, 2018), India (Kateel et al, 2018), China (Deng et al, 2018), Brazil (Bueno-Costa et al, 2016), Pakistan (Khalil et al, 2014), Australia (Wong et al, 2017), Spain (Osés et al, 2016), Malaysian (Tan et al, 2009), New Zealand (Lin et al, 2011), Mexican honey (Rodríguez et al, 2012). These studies provide an essential international perspective because the antimicrobial activity of honey obviously differs based on the composition, which is mainly dependent on geographical and botanical origins and postharvest treatment (Deng et al, 2018;Kiriakou et al, 2018).…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Tahir

Mariod

Mahunu

et al. 2019

Journal of Apicultural Science

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Honey production in Africa is considered an integral part of folk medicine and provides an opportunity for poor rural communities to increase their economic sustainability. In this review, we provide and discuss the data available on the positive nutritional value and health properties of honey harvested from Africa. Besides sugar, honey contains protein and amino acids, with proline which is about 50% of the total amino acids, vitamins, enzymes, some minerals (Na, K, Mg, Ca, Zn, Cu, Mn, Fe, P, S), trace elements (Mn, Ni, Li, F, I, Cl, Sr, Co) and polyphenol compounds. The paper reviewed studies on the use of African honey with anti-inflammatory, antioxidant, antibacterial, antifungal, anti-breast cancer, antidiabetic and antimycotic properties and also its positive effects on infertility (asthenozoospermia), febrile neutropenia and diabetic foot ulcers.

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Antibacterial action of Tropical honey on various bacteria obtained from diabetic foot ulcer

Cited by 18 publications

References 19 publications

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Physical characteristics and antimicrobial properties of Apis mellifera, Frieseomelitta nigra and Melipona favosa bee honeys from apiaries in Trinidad and Tobago

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

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