Antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives

Li, Pei; Shi, Li; Gao, Manni; Xia, Yang; Xue, Wei; Jin, Linhong; Hu, Deyu; Song, Baoan

doi:10.1016/j.bmcl.2014.12.038

Cited by 112 publications

(49 citation statements)

References 18 publications

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“…The chemical control of R. solanacearum is currently ineffective because of the far‐ranging host origin and long lifespan of this pathogen in soil and water. Although losses caused by this pathogen can be decreased through cultivation methods such as grafting (Rivard, O'Connell, Peet, Welker, & Louws, ) and crop rotation (Lemaga, Kanzikwera, Kakuhenzire, Hakiza, & Manzi, ) as well as through the use of biocontrol agents (Li, Shi, Gao, Yang, & Xue, ), the most appropriate control strategy thus far has been the breeding of varieties resistant to this pathogen. Once R. solanacearum comes in contact with the root, it secretes enzymes that degrade the root cell wall and invades the root of the plant host (Digonnet et al., ; Vailleau et al., ; Vasse, Frey, & Trigalet, ).…”

Section: Introductionmentioning

confidence: 99%

Early burst of reactive oxygen species positively regulates resistance of eggplant against bacterial wilt

Xiou

Lin

et al. 2017

Journal of Phytopathology

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Reactive oxygen species (ROS) play a crucial role in the early response to plant biotic and abiotic stresses. In this study, bacterial wilt‐resistant and wilt‐susceptible eggplants were inoculated with Ralstonia solanacearum and the ROS content was analysed. The result revealed an increased accumulation of hydrogen peroxide (H2O2) and superoxide (O2−) in resistant and susceptible eggplant roots after R. solanacearum inoculation. H2O2 and O2− accumulation increased earlier in the inoculated resistant eggplant root than in the inoculated susceptible eggplant root. Real‐time polymerase chain reaction results revealed that respiratory burst oxidase homologue (Rboh) A, RbohB, RbohF and PR1 expression levels increased in inoculated resistant eggplant roots at an early stage (0–60 h postinoculation) and were at higher expression levels than those in susceptible eggplant roots. Ascorbate peroxidase, peroxidase and catalase activities were higher in inoculated resistant eggplant roots than in susceptible eggplant roots at the early stage. Hence, an early ROS burst positively regulates bacterial wilt resistance in eggplant.

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Section: Introductionmentioning

confidence: 99%

Early burst of reactive oxygen species positively regulates resistance of eggplant against bacterial wilt

Xiou

Lin

et al. 2017

Journal of Phytopathology

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“…Indeed, the 1,3,4-thiadiazole heterocyclic ring system has been reported to have a wide range of pharmacological activities in the literature (42). To further develop this class of compounds, we performed a structure activity relationship (SAR) analysis, first by replacing the furan ring in AI-7–54 with thiophene, phenyl, 6-methyl-2-pyridyl, and pyrazine (Figure 1, Scheme 2).…”

Section: Resultsmentioning

confidence: 99%

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Illendula

Grembecka

et al. 2017

Leukemia & Lymphoma

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The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including the t(8;21) in acute myeloid leukemia (AML). Normal CBF function is essential for the activity of AML1-ETO, product of the t(8;21), and for the survival of several leukemias lacking RUNX1 mutations. Using virtual screening and further optimization, we developed Runt domain inhibitors (RDIs) which bind directly to the RD and disrupt its interaction with CBFβ On target activity was demonstrated by the RDIs’ ability to depress hematopoietic cell formation in zebrafish embryos, reduce growth and induce apoptosis of t(8;21) acute myeloid leukemia (AML) cell lines, and reduce progenitor activity of mouse and human leukemia cells harboring the t(8;21), but not normal bone marrow cells. RDIs had similar effects on murine and human T cell acute lymphocytic leukemia (T-ALL) cell lines. Our results confirmed that RDIs might prove efficacious in various AMLs and in T-ALL.

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“…PP3 and PP4 have not been previously reported, and so their inhibitory effects against Xoo have not yet been determined. However, Li et al found that 1,3,4‐thiadiazole sulfone derivatives were more effective than bismerthiazol against Xoo and Xoc . We suspect that PP3, a 1,3,4‐thiadiazole sulfone derivative, might also have high activity against these bacteria.…”

Section: Resultsmentioning

confidence: 99%

Photochemical degradation of bismerthiazol: structural characterisation of the photoproducts and their inhibitory activities against Xanthomonas oryzae pv. oryzae

Liang

Duan

et al. 2015

Pest Management Science

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Photodegradation increased the inhibitory activity of bismerthiazol against Xoo. The photodegradation pathway was inferred on the basis of the photoproducts of bismerthiazol. In vitro assays indicated that the sulfhydryl group was crucial for the inhibition of Xoo by bismerthiazol and its photoproducts. Bismerthiazol and 2-amino-5-mercapto-1,3,4-thiadiazole might have a similar mode action in vivo and in vitro.

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Antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives

Cited by 112 publications

References 18 publications

Early burst of reactive oxygen species positively regulates resistance of eggplant against bacterial wilt

Early burst of reactive oxygen species positively regulates resistance of eggplant against bacterial wilt

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Photochemical degradation of bismerthiazol: structural characterisation of the photoproducts and their inhibitory activities against Xanthomonas oryzae pv. oryzae

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