Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

Falkinham, Joseph O.; Macri, Richard V.; Maisuria, Bhadreshkumar B.; Actis, Marcelo L.; Sugandhi, Eko W.; Williams, André; Snyder, Alyson V.; Jackson, Faunice R.; Poppe, Michael; Chen, Liang; Ganesh, K. Sivajee; Gandour, Richard D.

doi:10.1016/j.tube.2011.12.002

Cited by 31 publications

(20 citation statements)

References 47 publications

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“…21,33,34 The tetramic acid derivatives, 1,2-dehydrovirgineone ( 2 ), virgineone ( 4 ), and virgineone aglycone ( 5 ), showed promising antimicrobial activity against S. aureus and several MRSA isolates, and compound 4 displayed moderate antifungal activity against Candida albicans , Cryptococcus neoformans , and A. niger (Table 3); these results were in agreement with those reported previously. 29 None of the compounds tested were active against E. coli and several strains of Mycobacterium (data not shown).…”

Section: Resultssupporting

confidence: 90%

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401)

et al. 2013

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An extract of the filamentous fungus Bionectria sp. (MSX 47401) showed both promising cytotoxic activity (>90% inhibition of H460 cell growth at 20 μg/mL) and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). A bioactivity-directed fractionation study yielded one new peptaibol (1) and one new tetramic acid derivative (2), and the fungus biosynthesized diverse secondary metabolites with mannose derived units. Five known compounds were also isolated: clonostachin (3), virgineone (4), virgineone aglycone (5), AGI-7 (6), and 5,6-dihydroxybisabolol (7). Compounds 5 and 7 have not been described previously from natural sources. Compound 1 represents the second member of the peptaibol structural class that contains an ester-linked sugar alcohol (mannitol) instead of an amide-linked amino alcohol, and peptaibols and tetramic acid derivatives have not been isolated previously from the same fungus. The structures of the new compounds were elucidated primarily by high field NMR (950 and 700 MHz), HRESIMS/MS, and chemical degradations (Marfey's analysis). All compounds (except 6) were examined for antibacterial and antifungal activities. Compounds 2, 4, and 5 showed antimicrobial activity against S. aureus and several MRSA isolates.

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Section: Resultssupporting

confidence: 90%

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401)

et al. 2013

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“…4 Gemini (dimeric) cationic amphiphiles in particular have received significant attention, 5 and the interesting physical properties 6 and antimicrobial activities 7 of these bis-cations have been described. Interesting developments have been made in the investigation of polyanionic structures by the groups of Falkinham and Gandour, [8][9][10][11][12] which have led to a series of dendritic amphiphiles, bearing three carboxylate groups that allow for attachment to surfaces (Fig. 1, left).…”

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The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms

Paniak

Jennings

Shanahan

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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“…abscessus strain AAy-P-1, M. avium strain A5, M. intracellulare strain 1406 T , M. chelonae strain EO-P-1, M. marinum strain ATCC 927, M. smegmatis strain VT 307, and M. bovis BCG strain ATCC 35745 (Connaught) were used in the study (15). The Fig.…”

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Transition Metal–α-Amino Acid Complexes with Antibiotic Activity against Mycobacterium spp

Karpin

Merola

Falkinham

2013

Antimicrob Agents Chemother

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Synthetic iridium-, rhodium-, and ruthenium-amino acid complexes with hydrophobic L-amino acids have antibiotic activity against Mycobacterium spp., including Mycobacterium bovis BCG and the rapidly growing species Mycobacterium abscessus and Mycobacterium chelonae. Concentrations of transition metal-amino acid complexes demonstrating hemolysis or cytotoxicity were 10-to 25-fold higher than were the MICs.

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Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

Cited by 31 publications

References 47 publications

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401)

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401)

The antimicrobial activity of mono-, bis-, tris-, and tetracationic amphiphiles derived from simple polyamine platforms

Transition Metal–α-Amino Acid Complexes with Antibiotic Activity against Mycobacterium spp

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