Antibacterial activities of honey against Escherichia coli and Staphylococcus aureus: A potential treatment for bacterial infections and alternative to antibiotics

Mudenda, Steward; Hikaambo, Christabel Nang Andu; Chabalenge, Billy; Mfune, Ruth Lindizyani; Mufwambi, Webrod; Ngazimbi, Moses; Matafwali, Scott Kaba; Daka, Victor

doi:10.22271/phyto.2023.v12.i3a.14655

Cited by 8 publications

(5 citation statements)

References 91 publications

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“…There has been an urge to support and strengthen the discovery of antibiotics from natural sources like traditional medicines [328]- [333]. The rise in resistance to conventional antimicrobials has caused a realisation of the significance of natural products like plants as sources of antimicrobials [322] [334] [335] [336] [337].…”

Section: Increasing Investment In the Development Of New Antimicrobialsmentioning

confidence: 99%

Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Mudenda,

Chabalenge,

Daka

et al. 2023

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Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hy-How to cite this paper:

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Section: Increasing Investment In the Development Of New Antimicrobialsmentioning

confidence: 99%

Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Mudenda,

Chabalenge,

Daka

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antiproliferative capacity [19] Capture and reduction of free radicals [17,18] Ability to invade and evade detection and removal by bacterial efflux mechanisms [22] Synergistic capacity of MGO with other known antibacterial materials in destruction of Gram+ and Gram− bacteria [23] Estrogenic activity involving MCF-7 pro-and antiproliferation capacity, and cytotoxicity [19,27,28] Topical antibiofilm agent relevant to wound healing [29] Macrophagic stimulation in aid of tissue healing due to bacterial damage and infection [30] Pronounced antibacterial capacity [31][32][33] Topical treatment for burn wound healing [34] Promotion of healing post-craniomaxillofacial surgery, and reduction of complications associated with healing [35] 3. Blood Infection…”

Section: Activities and Applications Of Honey Referencesmentioning

confidence: 99%

Honey as a Natural Nutraceutical: Its Combinational Therapeutic Strategies Applicable to Blood Infections—Septicemia, HIV, SARS-CoV-2, Malaria

2023

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Honey is a natural substance that has existed alongside humanity since the time of antiquity, acting then as a source of nutrition, as well as a source of medicinal aid for people. Ancient civilizations from multiple nations of the world, from ancient China to ancient Greece and Egypt, utilized the supposed healing properties of honey to treat lacerations and wounds, as well as for internal pathologies such as intestinal disease. At present, honey has entered the modern scientific research program in search of novel antibiotics. In recent research, honey has demonstrated its potential use for static and/or cidal effects on microbial strains which are becoming resistant to chemical antibiotics. Additionally, the use of honey as an agent of treatment for more severe infections, namely blood infections pertaining to septicemia, HIV, and SARS-CoV-2, as well as parasitic infections such as malaria, have also been investigated in recent years. In this article, the literature has been reviewed on some of the therapeutic properties of natural nutraceutical honey, where it has been observed to act as a potential ameliorating agent; reducing the severity of such conditions that may amplify a disease, as well as reducing the progression of the disease and its symptoms.

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“…To this effect, there is a need for intensified research to identify novel antimicrobial compounds from natural products [22][23][24] . Cassia abbreviata (C. abbreviata) is one of the plants with vast medicinal values [25,26] .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Cassia abbreviata oliv roots against Neisseria gonorrhoeae: A potential traditional medicine for the treatment of sexually transmitted infections

Mudenda,

Chalwe,

Kabuka

et al. 2024

J. Med. Plants Stud.

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Traditional medicines are useful in the management of various diseases, especially in low-and middleincome countries. This study analysed the antibacterial activity of Cassia abbreviata Oliv roots against Neisseria gonorrhoeae. This was a laboratory-based study in which the extracts of Cassia abbreviata Oliv roots were tested against Neisseria gonorrhoeae. Additionally, the extracts of Cassia abbreviata Oliv roots were combined with tetracycline to determine their synergistic effect. Data were analysed using IBM SPSS version 22.0. All extracts were active against Neisseria gonorrhoeae, with a minimum inhibitory concentration of 125 µg/ml for the ethanol and 62.5 µg/ml for the aqueous extract. Despite both extracts having antibacterial activity against Neisseria gonorrhoeae, their effect were lower than that of tetracycline. There was an increase in activity when tetracycline was combined with aqueous extract. This study demonstrated that traditional medicines should be studied further for use in drug discovery, especially with increasing resistance to conventional antibiotics.

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Antibacterial activities of honey against Escherichia coli and Staphylococcus aureus: A potential treatment for bacterial infections and alternative to antibiotics

Cited by 8 publications

References 91 publications

Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Honey as a Natural Nutraceutical: Its Combinational Therapeutic Strategies Applicable to Blood Infections—Septicemia, HIV, SARS-CoV-2, Malaria

Antibacterial activity of Cassia abbreviata oliv roots against Neisseria gonorrhoeae: A potential traditional medicine for the treatment of sexually transmitted infections

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