Antibacterial activities of medicinal plants used for the treatment of diarrhoea in Limpopo Province, South Africa

Mathabe, Matlakala Christina; Nikolova, R.V.; Lall, Namrita; Nz, Nyazema

doi:10.1016/j.jep.2006.01.029

Cited by 236 publications

(194 citation statements)

References 32 publications

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“…Food-borne illnesses are still an important concern for both consumers, the food industry and food safety authorities, thus, the ongoing search for natural antimicrobials for prevention of food-borne illnesses is a vast exploring area for scientists. Antimicrobial activities of pomegranate have been studied by some researchers and the extent of inhibitory effect is always attributed to the pomegranate antioxidant activity that depends mainly on the phenolic and anthocyanin content of the fruit (Holetz et al, 2002;Braga et al, 2005;Mathabe et al, 2006;McCarrell et al, 2008;Al-Zoreky, 2009;Duman et al, 2009;Gould et al, 2009;Parashar et al, 2009;Panichayupakaranant et al, 2010, Orak et al, 2011. In a previous study, Opara et al (2009) reported that the best activity against Staphyloccocus aureus and Pseudomonas aeruginosa were found in fruit peel compound punicalagin, particularly from Oman, which was coincident with the highest levels of vitamin C detected in these samples.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Section: Antimicrobial Propertiesmentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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“…X. caffra stands out for being used in Tanzania for the treatment of irregular menstruation, rheumatism and cancer (Chhabra & Viso, 1990) and, in Limpopo Province, South Africa, for treatment diarrhea (Mathabe, 2006). However, X. americana Linn.…”

Section: Introductionmentioning

confidence: 99%

Ximenia americana: Chemistry, Pharmacology and Biological Properties, a Review

Monte¹,

Lemos²,

Araújo³

et al. 2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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“…Antitumour (Afaq et al, 2005;Lansky and Newman, 2007), antibacterial (Prashanth et al, 2001;Braga et al, 2005;Menezes et al, 2006;Aqil, Ahmad, 2007), antidiarrhoeal (Das et al, 1999;Mathabe et al, 2006), antifungal (Dutta et al, 1998Vasconcelos et al, 2003;Vasconcelos et al, 2006), antiulcer (Gharzouli et al, 1999), and antioxidant pharmacological properties have been reported for various extracts/constituents of different parts of this plant species. Recently, the antioxidant activity of P. granatum associated with its phytochemicals, such as, polyphenols, flavonoids, and anthocyanidins has gained importance (Faria et al, 2007;Guo et al, 2007;Kulkarni et al, 2007;Mirdehghan et al, 2007;Reddy et al, 2007;Rout, Banerjee, 2007;Sestili et al, 2007;Zaid et al, 2007).…”

Section: Introductionmentioning

confidence: 97%

Assessment of mutagenic and antimutagenic effects of Punica granatum in mice

Valadares

Pereira

Benfica

et al. 2010

Braz. J. Pharm. Sci.

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In the present study, the ability of Punica granatum ethanolic leaf extract (PGL) and Punica granatum ethanolic fruit extract (PGF) to induce mutagenicity or to modulate the genotoxic effects induced by the alkylating agent cyclophosphamide (CP) was evaluated. Swiss male mice were treated by gavage for 10 days with PGL or PGF (12.5, 25, 50, and 75 mg/kg/day) prior to exposure to CP (i.p. 200 mg/kg), 24 h after the end of the treatment. Initial observations revealed that normal mice treated with both extracts (12.5, 25, 50, and 75 mg/kg/day) showed a similar micronucleated polychromatic erythrocyte (MNPCE) frequency to that of the control group. Investigation of the protective effect of PGL and PGF based on data analysis revealed that, irrespective of dose or extract, oral administration of PGL or PGF for 10 days prior to exposure had reduced, in a dose-dependent manner, the frequency of MNPCE induced by CP in all groups studied. Higher reductions were observed at PGF doses of 50 and 75 mg/kg. Taken together, these results demonstrate that mice treated with P. granatum showed an absence of mutagenic effects and dose-dependent protective effects against CP-induced oxidative DNA damage. Uniterms:Punica granatum/mutagenic effects. Punica granatum/antimutagenic effects. Micronucleic. Genotoxicity. Cyclophosphamide.No presente estudo investigamos o potencial do extrato etanólico das folhas da Punica granatum (PGFO) e do extrato etanólico dos frutos da Punica granatum (PGFR) de induzir mutagenicidade ou de proteger contra efeitos genotóxicos induzidos pela ciclofosfamida (CF). Camundongos machos Swiss foram tratados por 10 dias, via oral, com PGFO ou PGFR (12,5, 25, 50 e 75 mg/kg/dia), previamente a exposição à CF (i.p. 200 mg/kg) 24 horas após término do tratamento. Observamos que os animais tratados por 10 dias com ambos os extratos (12,5, 25, 50 e 75 mg/kg/dia) demonstraram a frequência de micronúcleo policromático eritrocitário (MNPCE) similar ao grupo controle. Quando aos efeitos protetores dos extratos foram investigados, a análise dos dados revelou que, independentemente da dose ou do extrato usado, a administração oral por 10 dias, previamente à exposição, reduziu, de forma dose-dependente, a frequência de MNPCE induzidos pela CF, em todos os grupos estudados. As maiores reduções foram observadas com PGFR nas doses de 50 e 75 mg/kg. Em conjunto, sob as condições testadas, camundongos tratados com P. granatum demonstraram ausência de efeitos mutagênicos e, de forma dose-dependente, efeitos protetores contra os danos oxidativos do DNA induzidos pela CF. Unitermos:Punica granatum/efeitos mutagênicos. Punica granatum/efeitos antimutagênicos. Micronúcleo. Genotoxicidade. Ciclofosfamida. INTRODUCTIONPunica granatum Linn., a Punicaceae, commonly known as pomegranate, has a vast ethnomedical history and represents a phytochemical reservoir of heuristic medicinal value (Lansky and Newman, 2007). The plant as a whole and especially its flowers, have been extensively used in the ancient Ayurvedic health care system (Siv...

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Antibacterial activities of medicinal plants used for the treatment of diarrhoea in Limpopo Province, South Africa

Cited by 236 publications

References 32 publications

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Ximenia americana: Chemistry, Pharmacology and Biological Properties, a Review

Assessment of mutagenic and antimutagenic effects of Punica granatum in mice

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