Antibacterial activities of natural lichen compounds against Streptococcus gordonii and Porphyromonas gingivalis

Sweidan, Alaa; Chollet-Krugler, Marylène; Sauvager, Aurélie; Weghe, Pierre van de; Chokr, Ali; Bonnaure‐Mallet, Martine; Tomasi, Sophie; Bousarghin, Latifa

doi:10.1016/j.fitote.2017.07.011

Cited by 26 publications

(18 citation statements)

References 24 publications

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“…Consequently, one hypothesis explaining these observations might be that some other compounds should be associated to usnic acid to support the observed antifungal activities. Recent published study of Sweidan et al [62] support this hypothesis. This hypothesis is supported by the fact that usnic acid was previously associated to chloroatranorin to explain the antimicrobial activity of both Ramalina lichens.…”

Section: Discussionmentioning

confidence: 86%

“…One of this synergic pool seems to be usnic acid associated with aliphatic acids and/or depsides. Recent published study of Sweidan et al [62] support this hypothesis. They found that (+)-roccellic acid, an aliphatic acid, and demethylbarbatic acid, a despide, had promising antibacterial activity against two oral bacteria: Streptococcus gordonii and Porphyromonas gingivalis.…”

Section: Discussionmentioning

confidence: 86%

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UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

Rafika

Ahmed

Burger

et al. 2018

Chemistry & Biodiversity

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Lichens are complex symbiotic organisms able to produce a vast array of compounds. The Algerian lichen diversity has only prompted little interest even given the 1085 species listed. Herein, the chemodiversity of four Algerian lichens including Cladonia rangiformis, Ramalina farinaceae, R. fastigiata, and Roccella phycopsis was investigated. A dereplication strategy, using ultra high performance liquid chromatography-high resolution-electrospray ionization-mass spectrometry (UHPLC-HRMS/MS), was carried out for a comprehensive characterization of their substances including phenolics, depsides, depsidones, depsones, dibenzofurans, and aliphatic acids. Some known compounds were identified for the first time in some species. Additionally, the lichenic extracts were evaluated for their antifungal and antimicrobial activities on human pathogenic strains (Candida albicans, C. glabrata, Aspergillus fumigatus, Staphylococcus aureus, and Escherichia coli). Cyclohexane extracts were found particularly active against human pathogenic fungi with MIC values ranging from 8 to 62.5 μg/mL, without cytotoxicity. This study highlights the therapeutic and prophylactic potential of lichenic extracts as antibacterial and antifungal agents.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 86%

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

Rafika

Ahmed

Burger

et al. 2018

Chemistry & Biodiversity

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“…In the human liver hepatocellular carcinoma cell line HepG2, the test compounds did not show any cytotoxic effect, even at a high concentration (75 µM). It is recognized that lipophilicity is an essential physicochemical characteristic of any drug which outlines the permeation within biological membranes via passive diffusion [ 18 ]. Thus, a prosperous biological effect relies on the relationship between the hydrophilic and hydrophobic properties of the drug or biologically active substances.…”

Section: Resultsmentioning

confidence: 99%

“…Lichens are symbiotic associations of two different organisms usually fungus and one or several algae or cyanobacteria (a photosynthetic partner). Lichens can produce more than 1000 different bioactive metabolites (including phenolic compounds, pulvinic acid and its derivatives, quinine and its derivatives, dibenzofurans, and lactones) with prominent pharmacological efficacies [ 18 ]. Hitherto, many lichen metabolites were reported to harbor antibacterial propensity against multidrug-resistant human pathogens and lichens have a history of being used as antibiotics against several strains of M.tb [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although PA was first isolated in the year 1880, its structure was resolved in 1958 [ 20 ]. Of late, a mounting body of research evidence has shown diverse pharmaceutical properties of PA, including anti-tumour, antigenotoxic, antibacterial, antiplasmodial, cytotoxic, antioxidant, and osteoporosis-inducing characteristics, as well as cardiovascular effects [ 18 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Antimycobacterial, Enzyme Inhibition, and Molecular Interaction Studies of Psoromic Acid in Mycobacterium tuberculosis: Efficacy and Safety Investigations

Hassan

Šudomová²,

Berchová‐Bímová

et al. 2018

JCM

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The current study explores the antimycobacterial efficacy of lichen-derived psoromic acid (PA) against clinical strains of Mycobacterium tuberculosis (M.tb). Additionally, the inhibitory efficacy of PA against two critical enzymes associated with M.tb, namely, UDP-galactopyranose mutase (UGM) and arylamine-N-acetyltransferase (TBNAT), as drug targets for antituberculosis therapy were determined. PA showed a profound inhibitory effect towards all the M.tb strains tested, with minimum inhibitory concentrations (MICs) ranging between 3.2 and 4.1 µM, and selectivity indices (SIs) ranging between 18.3 and 23.4. On the other hand, the standard drug isoniazid (INH) displayed comparably high MIC values (varying from 5.4 to 5.8 µM) as well as low SI values (13.0–13.9). Interestingly, PA did not exhibit any cytotoxic effects on a human liver hepatocellular carcinoma cell line even at the highest concentration tested (75 µM). PA demonstrated remarkable suppressing propensity against UGM compared to standard uridine-5'-diphosphate (UDP), with 85.8 and 99.3% of inhibition, respectively. In addition, PA also exerted phenomenal inhibitory efficacy (half maximal inhibitory concentration (IC50) value = 8.7 µM, and 77.4% inhibition) against TBNAT compared with standard INH (IC50 value = 6.2 µM and 96.3% inhibition). Furthermore, in silico analysis validated the outcomes of in vitro assays, as the molecular interactions of PA with the active sites of UGM and TBNAT were unveiled using molecular docking and structure–activity relationship studies. Concomitantly, our findings present PA as an effective and safe natural drug plausible for use in controlling tuberculosis infections.

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Lichens as Sources of Antibacterial Compounds

Youness

Chouati²,

Aoussar

et al. 2020

Lichen‐Derived Products

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Antibacterial activities of natural lichen compounds against Streptococcus gordonii and Porphyromonas gingivalis

Cited by 26 publications

References 24 publications

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

Antimycobacterial, Enzyme Inhibition, and Molecular Interaction Studies of Psoromic Acid in Mycobacterium tuberculosis: Efficacy and Safety Investigations

Lichens as Sources of Antibacterial Compounds

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