2017
DOI: 10.1007/s00775-017-1461-4
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Antibacterial activities of sulfamethoxazolyl-azo-phenols and their Cu(II) complexes along with molecular docking properties

Abstract: Sulfamethoxazolyl-azo-phenols [SMX-N=N-CH(R)(R)-OH] (1a, 2a) and their Cu(II) complexes, [Cu(SMX-N=N-CH(R)(R)-O)] (1b, 2b) (R = p-OMe, R = H, 1a/1b; R = p-Cl, R = m-CH, 2a/2b) show antibacterial sensitivity against Gram-positive bacteria, B. subtillis; IC: 281.47 ± 1.84 μM (1a), 126.39 ± 1.66 μM (1b), and 279.94 ± 3.15 μM (2a), 123.62 ± 1.27 μM(2b), and Gram-negative bacteria, E. coli; IC: 204.66 ± 3.31 μM (1a) and 89.05 ± 1.48 μM (1b), 223.13 ± 2.71 μM (2a), and 98.26 ± 1.59 μM (2b). Interaction of DNA with f… Show more

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