Antibacterial Activitv of the Heartwood of Haematoxylon braziletto**University of California, School of Pharmacy, San Francisco 22

ANTIINFLAMMATORY PRINCIPLES OFCAESALPINIA SAPPANWOOD AND OFHAEMATOXYLON CAMPECHIANUMWOOD1

“…Concerning the common physiological activities of brazilin and hematoxylin, the following are known: both the substances restored activity of the frog heart poisoned by various chemicals (GABOR and HORVATH, 1953), they prolonged the effect of adrenalin in surviving organs and in vivo , and they were effective in restoring lowered and normal capillary resistance in rats (GABOR and Dux,'1952). It was also found that brazilin had the bacteriostatic activity against a number of microorganisms (SANCHEZ-MORROQU~N et al, 1958;PRATT and YUZURIHA, 1959;DE LIMA et al, 1959), and hematoxylin, when administered together with dimethyl sulfoxide to mice carrying a transplantable lymphosarcoma, caused cellular alterations leading to distinct tissue and cellular degeneration (ROGERS, 1970). However, brazilin has not been known to possess antiinflammatory activity though hematoxylin was reported to decrease mustard oil inflammation in rabbit skin (GABOR and S Z~R~D Y , 1952).…”

Synthesis of Aza-brazilin/diarylindan-Based Hybrid

“…(＋)-Brazilin 是从药材苏方木中分离得到的天然产 物, 具有抗菌 [5] 、抗炎 [6] 、降低血液粘度 [7] 、抑制端粒酶 活性 [8] 及切割 DNA [9] 等, 其衍生物的合成方法及活性研 究也因此引起了许多课题组的兴趣 [10～12] . 最近, 我们报 道了氮杂 brazilin 4b 及其一些衍生物的合成, 发现他们 具有较好的抗肿瘤活性 [13] .…”