Antibacterial activity against Escherichia coli of Cu‐BTC (MOF‐199) metal‐organic framework immobilized onto cellulosic fibers

Abstract

A strong antimicrobial activity against Escherichia coli of Cu‐BTC metal‐organic frameworks immobilized over cellulosic fibers is hereby reported. The in situ synthesis of Cu‐BTC metal‐organic frameworks, aka MOF‐199 or HKUST‐1, onto cellulosic substrates was carried out by exposing carboxymethylated cellulosic substrates to Cu(OAC)2, 1,3,5‐benzenetricarboxylic acid and triethylamine solutions following a very specific order. Using an in vitro model, in accordance to ASTM E2149‐13a, we observed that the cellulose‐MOF system was able to completely eliminate the growth of E. coli on agar plates and liquid cultures. The antibacterial activity of the comprising components of MOF‐199 and the cellulosic substrate was also evaluated and determined to be negligible. Since the method used to synthesize MOF‐199 crystals provides a strong bond between the crystals and the cellulosic substrates, the crystals not detach from the anionic cellulosic fibers allowing the modified textile to be washed and reused hence opening a new avenue to fabricate antibacterial clinical fabrics. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40815.

The Effect of Cu-BPDCA-Ty on Antibacterial Activity and The Expression of mecA Gene in Clinical and Standard Strains of Methicillin-Resistant Staphylococcus aureus

“…The antibacterial mechanism of this compound is related to the release of Cu and after destroying the wall and membrane and entering the cell, an enzymatic activity is targeted in the bacterium, which ultimately leads to a reduction in gene expression (26,27 (28,29). Similar to previous studies (30)(31)(32)(33), the present study found that the antibacterial activity of nanostructures includes metal/metal oxide copper. The real-time PCR method is sensitive and commonly used to detect gene expression.…”

In situ green preparation and antibacterial activity of copper-based metal–organic frameworks/cellulose fibers (HKUST-1/CF) composite

“…The Cu 2? ions in HKUST-1 possessed the cytotoxicity against bacteria, which might destroy the structure of bacterial cell membrane via transforming membrane proteins and fatty acids or altering transmembrane potential to make an adverse impact on the growth and reproduction of bacteria (Rodriguez et al 2014). When microorganisms contact with the HKUST-1/CF composite, Cu 2?…”

“…Based on the recognized ability of HKUST-1 to capture gases and toxic chemicals, combined with Cellulose the availability of cellulose-based fibrous materials, the described procedure provided the basis for future fabrication of functionalized fibers and active filtration media. Rodriguez et al (2014) in situ synthezed HKUST-1 onto carboxymethylated cellulosic fabrics, and they observed that the cellulose-MOF system was able to completely eliminate the growth of Escherichia Coli (E. coli) on agar plates and liquid cultures. Lange and Obendorf functionalized cotton fibers by partial etherification and self-assembly of polyoxometalate (POM, [CuPW 11 O 39 ] 5-) encapsulated in Cu 3 (BTC) 2 metal-organic framework (HKUST-1) (Lange and Obendorf 2015).…”

“…Therefore, a novel MOF/CF composite has been studied and developed in recent years (Küsgens et al 2009;da Silva Pinto et al 2012;Rodriguez et al 2014;Lange and Obendorf 2015;Chui et al 1999).…”

Introductory Chapter: Metal Organic Frameworks (MOFs)

“…They also bear the ability to systematically vary and functionalize their pore structure [2,3]. In the history of MOFs, a benchmark was represented by the synthesis of MOF-5 (Zn 4 O(bdc) 3 , bdc = terephthalate) and HKUST-1 (Cu 3 (btc) 2 , btc = 1,3,5-benzenetricarboxylate) with high porosity and low pressure gas sorption, followed by the development of chromium(III) terephthalate (MIL-101) with high chemical stability, MOF-74 (Zn 2 (dhbdc), dhbdc = 2,5-dihydroxy-1,4-benzenedicarboxylate) with low pressure adsorption of CO 2 , and several isostructural analogs of Mg-MOF-74 termed as IRMOF-74-I to IRMOF-74-XI, with large pore apertures to accommodate protein, NU-110E with acetyleneexpanded hexatopic linker, having material highest experimental Brunauer-Emmett-Teller (BET) surface area of any porous material reported to date (7140 m Table 1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. …”