Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Souza, Antônio Barros de; Pinheiro, Jacqueline Cosmo Andrade; Soares, João B. P.; Araújo, José Ismael Feitosa de; Araújo, Sandra Maria Barbosa de; Batista, Francisco Lucas Alves; Sousa, Kalina Kelma Oliveira de; Tintino, Saulo Relison; Araújo, Isaac Moura; Magalhães, Francisco Ernani Alves; Leite, Laura Hévila Inocêncio; Azevedo, Francisco Roberto de

doi:10.1016/j.fsirep.2023.100108

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Clinical and pre-clinical studies prove that flavonoids and saponins act through selective binding to GABAA receptors, promoting membrane hyperpolarization by allowing the influx of chloride anions, accompanied by inhibition of excitatory transmission, which consequently contribute to the reduction of anxiety disorders [9], [32]. This hypothesis is corroborated by previous studies that show the anxiolytic potential of S. joazeiro, flavonoids and saponins through GABAergic neurotransmission in zebrafish and mice [8], [11], [33].…”

Section: Discussionsupporting

confidence: 73%

“…Popularly known as "juá", "joazeiro", it is native to the Brazilian Northeast and endemic to the caatinga. In traditional medicine, it is used in the therapy of dermatological, respiratory, and digestive problems, in addition, it exhibits antioxidant, anti-inflammatory and antimicrobial properties [11]. Chemical data indicate the presence of flavonoid and saponin derivatives, which have reported and well-established anxiolytic activities [12], [13].…”

Section: Introductionmentioning

confidence: 99%

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UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Costa,

De Carvalho,

Pereira da Silva

et al. 2024

Preprint

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Anxiety is a multifactorial pathology associated with oxidative stress and changes in different neurotransmitters in the central nervous system (CNS). Sarcomphalus joazeiro (Rhamnaceae) has a predicted effect on the CNS, being considered an alternative for pre-clinical investigations of anxiolytic drugs. The objective of this study is to evaluate the chemical composition, analyze the antioxidant capacity and the anxiolytic effect of the ethanolic extract of S. joazeiro leaves (EEFSJ) in zebrafish. The chemical profile was analyzed by liquid chromatography coupled to mass spectrometry (UPLC-PDA-ESI-QDA). Antioxidant action by DPPH• elimination and ABTS•⁺ capture assays. The 96 h acute toxicity and open field and light and dark tests, for sedative and anxiolytic evaluation, respectively, were applied in vivo, using zebrafish. It was possible to identify 11 compounds from the flavonoid and saponin class. EEFSJ exhibited a mean inhibitory concentration (IC50) of 185.2 ± 2.2 µg/mL and 74.17 ± 1.5 µg/mL against the DPPH• and ABTS•⁺ radicals, respectively. In vivo, EEFSJ demonstrated reduced locomotor activity and an anxiolytic effect similar to diazepam via GABAergic systems, without presenting toxicity within 96 h. These results suggest the safety of using EEFSJ for the development of clinical trials for the production of new anxiolytic drugs.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Costa,

De Carvalho,

Pereira da Silva

et al. 2024

Preprint

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show abstract

“…Microorganisms affect the human defense system in many different ways, with their impact ranging from mild to life-threatening conditions. These infections occur when harmful bacteria invade the body, leading to a host immune response that can result in localized or systemic symptoms ( de Souza et al, 2023 ). Figueira et al ( W Figueira et al, 2020 ) investigated the effect of turmeric volatile oil on Gram-positive bacteria , Gram-negative bacteria and fungi .…”

Section: Manuscript Formattingmentioning

confidence: 99%

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Zhu,

Quan,

Yin

et al. 2023

Front. Pharmacol.

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Curcumae Longae Rhizoma (turmeric), Curcumae Radix and Curcumae Rhizoma are derived from the Curcuma species, and have gradually become three of the most commonly used medicinal herbs in China due to their different origins, processing methods and medicinal part. These three herbs have certain similarities in morphology, chemical composition, and pharmacological effects. All three of these herbs contain curcuminoids and volatile oil compounds, which exhibit anti-inflammatory, anti-tumor, antioxidant, and neuroprotective properties, although modern clinical applications have their own requirements. At present, there is no systematic guidelines for the clinical application of these three of Curcuma species; consequently, there is a high risk of unwanted phenomena associated with the mixing and indiscriminate use of these herbs. In this review, we focus predominantly on morphology, chemical composition, and the pharmacological activity of these three Curcuma herbs and summarize the current status of research in this field. Our goal is to provide a better understanding of clinical value of these Curcuma species so that we can provide reference guidelines for their further development, utilization and rational clinical application.

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Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)

Marques,

Rocha,

Nascimento

et al. 2024

Neurochemistry International

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Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Cited by 4 publications

References 37 publications

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

UPLC-PDA-ESI-QDA Characterization and Evaluation of the Antioxidant and Anxiolytic Activities of the Ethanolic Extract of <em>Sarcomphalus joazeiro</em> (Mart.) Hauenschild Leaves

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)

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