Antibacterial activity and biocompatibility of a chitosan–γ-poly(glutamic acid) polyelectrolyte complex hydrogel

Tsao, Ching Ting; Chang, Chien Hsin; Lin, Yi‐Fang; Wu, Ming-Jiuan; Wang, Jaw‐Lin; Han, J. L.; Hsieh, K. H.

doi:10.1016/j.carres.2010.06.002

Cited by 155 publications

(101 citation statements)

References 40 publications

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“…The absorption band at 1628 cm −1 corresponds to the amide bond of the undeacetylated part in GC and the N-H bending vibration of the free amine group of the deacetylated part in GC resulted in a peak at 1546 cm −1 [19]. The peaks at 1110 and 1064 cm may be ascribed to a glycosidic linkage (ether bond) and C-N vibrations, respectively [22]. Interestingly, the amide absorption band in glycol chitosan shifted from 1649 to 1628 cm −1 after interaction with IONPs.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…figure 1 show FTIR spectra of pure GC and GC-coated IONPs, respectively. There is a strong broad band at 3397 cm −1 in GC-coated IONPs, which may be attributed to an overlap of O-H and N-H stretching vibrations [20,21], while the peak at 2924 cm −1 may be assigned to a C-H stretching vibration [21,22]. The absorption band at 1628 cm −1 corresponds to the amide bond of the undeacetylated part in GC and the N-H bending vibration of the free amine group of the deacetylated part in GC resulted in a peak at 1546 cm −1 [19].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…However, the coating of IONPs with GC enhanced water solubility, and thus, the hydrophilic nature of GC-coated IONPs may significantly contribute to their antibacterial action, as the hydrophobic interaction between a microorganism and a substrate would facilitate microbial adhesion and proliferation [22,33]. It has been well documented that the bacterial adhesion can be markedly enhanced when both bacterial and adherent surfaces are hydrophobic, but the adhesion is hindered if both surfaces are hydrophilic [32,33].…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Inbaraj

Tsai

Chen

2012

Science and Technology of Advanced Materials

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Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g −1 , respectively. The IONP size was measured as ∼ 8-9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency against E. coli O157:H7 and Staphylococcus aureus ATCC 10832 than bare IONPs. Given their biocompatibility and antibacterial properties, GC-coated IONPs are a potential nanomaterial for in vivo applications.

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Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

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Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Inbaraj

Tsai

Chen

2012

Science and Technology of Advanced Materials

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“…To date, only the effect of weight-averaged molecular weight (M W ) and degree of N-acetylation (DA) on the physicochemical and biological properties of these compounds has been intensively investigated. The results are summarized in a number of papers, (e.g., [17,21,[43][44][45][46]). Selected relationships between the structural parameters DA and M W , and the physicochemical and biological properties are presented in Figure 3.…”

Section: Introductionmentioning

confidence: 99%

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

et al. 2011

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Abstract:The physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (M W ) and degree of N-acetylation (DA), other physicochemical parameters like polydispersity (M W /M N ), crystallinity or the pattern of acetylation (P A ) have to be taken into consideration. From the biological point of view, these parameters affect a very important factor-the solubility of chitin and chitosan in water and organic solvents. The physicochemical properties of chitosan solutions can be controlled by manipulating solution conditions (temperature, pH, ionic strength, concentration, solvent). The degree of substitution of the hydroxyl and the amino groups or the degree of quaternization of the amino groups also influence the mechanical and biological properties of chitosan samples. Finally, a considerable research effort has been directed towards developing safe and efficient chitin/chitosan-based products because many factors, like the size of nanoparticles, can determine the biomedical characteristics of medicinal products. The influence of these factors on the biomedical activity of chitin/chitosan-based products is presented in this report in more detail. OPEN ACCESSPolymers 2011, 3 1876

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“…36,42 This high purity level is very attractive since commercially available g-PGA usually has low (c.a. 70%) or unknown purity levels, 33,[43][44][45] which may hinder its application in the biomedical field, and especially when it comes to clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells

Antunes

Tsaryk

et al. 2015

Tissue Engineering Part A

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Antibacterial activity and biocompatibility of a chitosan–γ-poly(glutamic acid) polyelectrolyte complex hydrogel

Cited by 155 publications

References 40 publications

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Synthesis, characterization and antibacterial activity of superparamagnetic nanoparticles modified with glycol chitosan

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells

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