Antibacterial Activity and Cytocompatibility of PLGA/CuO Hybrid Nanofiber Scaffolds Prepared by Electrospinning

Haider, Adnan; Kwak, Sanghwa; Gupta, K. C.; Kang, Inn‐Kyu

doi:10.1155/2015/832762

Cited by 60 publications

(40 citation statements)

References 35 publications

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“…Furthermore, as seen, cell–biomaterial interaction is improved by incorporating more cell‐adhesion molecules necessary for cell mobility and resulted in a spread in all directions, along with an increase in L929 cell numbers that adhered on the membranes as a suitable matrix (cell proliferation). It seems that cellular response was influenced by (a) Gel as a natural polymer with unique structure and properties, (b) the antibacterial nature of CIP (preventing infection), and (c) the porous structure of mat (mimicked natural ECM), which would help cells move from surface into membranes through pores (guideline channels) …”

Section: Resultsmentioning

confidence: 99%

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

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In this research, gelatin and poly(glycerol sebacate) (PGS), which have demonstrated significantly developed wound healing process, were used to fabricate biodegradable and bioabsorbable membranes with controlled release of ciprofloxacin (CIP) as a powerful antibiotic. This was achieved by taking advantage of electrospinning technique to accelerate the wound healing as an extracellular matrix-liked composite membrane. We attempted to carefully investigate the impact of variable ratio of sebacic acid and glycerol as components of PGS and identified CIP-loaded cross-linked membrane (CIP-M 11 ) as an optimum membrane, although a significant change in structural properties of samples was not observed. The physicochemical properties of drug-loaded electrospun wound cover were evaluated by several characterization tests.Scanning electron microscopy and Fourier transform infrared spectroscopy results confirmed that CIP-embedded gelatin/PGS membrane was successfully synthesized and cross-linked properly. The CIP-M 11 sample showed a constant and uniform degradation rate with the capacity of durable drug release over the time period. The excellent antibacterial activity of CIP decreased the population of both Escherichia coli and Staphylococcus aureus bacteria and prevented bacterial infections. The cytocompatibility of membranes was completely proven by culturing L929 fibroblast cells on the prepared membranes. Finally, obtained results exhibit that the membranes should be considered as the promising wound dressing.

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Section: Resultsmentioning

confidence: 99%

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

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“…Nanofibers are typically created by an electrostatic field from a polymer solution by electrospinning [5,6]. Various functional materials can be incorporated into the nanofibers during the electrospinning to enhance desired attributes, such as catalytic [7], biocidal [8,9], or hydrophobic properties [10].…”

Section: Introductionmentioning

confidence: 99%

Flux Enhancement in Membrane Distillation Using Nanofiber Membranes

Jiźíźek

Komárek

Chaloupek

et al. 2016

Journal of Nanomaterials

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Membrane distillation (MD) is an emerging separation technology, whose largest application potential lies in the desalination of highly concentrated solutions, which are out of the scope of reverse osmosis. Despite many attractive features, this technology is still awaiting large industrial application. The main reason is the lack of commercially available membranes with fluxes comparable to reverse osmosis. MD is a thermal separation process driven by a partial vapour pressure difference. Flux, distillate purity, and thermal efficiency are always in conflict, all three being strictly connected with pore size, membrane hydrophobicity, and thickness. The world has not seen the ideal membrane yet, but nanofibers may offer a solution to these contradictory requirements. Membranes of electrospun PVDF were tested under various conditions on a direct contact (DCMD) unit, in order to determine the optimum conditions for maximum flux. In addition, their performance was compared to commonly available PTFE, PE, and PES membranes. It was confirmed that thinner membranes have higher fluxes and a lower distillate purity and also higher energy losses via conduction across the membrane. As both mass and heat transfer are connected, it is best to develop new membranes with a target application in mind, for the specific membrane module and operational conditions.

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“…The two prominent peaks corresponding to the monocrystalline nature of CuO nanoparticles were observed. The high intensity peaks were observed at 35 [16]. All the diffraction peaks are coded as the usual monoclinic structure.…”

Section: Resultsmentioning

confidence: 99%

“…The results are showed in Table-2. The potential technique associated with the function of bacteria may be caused by cell membrane [34,35]. The released of copper ions from CuO nanoparticles, which negatively attached the bacterial cell wall to the charging and fracture, causing protein attenuation and cell death [36][37][38].…”

Section: Resultsmentioning

confidence: 99%

A Strains Activity of CuO Nanoparticles using Copper Chloride Dihydrate by Sol-Gel Method

Arunkumar¹,

Jeyakumar²,

Jothibas³

2019

Asian J. Chem.

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Copper(II) oxide (CuO) nanoparticles synthesized by different molarities like 0.1, 0.2 and 0.3 M at calcinations temperature 450 ºC. The XRD results analyzed the prominent peaks corresponding to the monocrystalline nature of CuO nanoparticles and the average crystalline size of CuO nanoparticles size is decreased with increase of molarities. From SEM image of CuO nanoparticles, the particles are well scattered, which are well connected and consistent with the crystal system. The absorption spectra shows the blue shift which can be attributed to the small size of CuO nanostructures. The FTIR spectra confirmed high intense broad band peaks at 496.96 cm-1 and assigned to characteristics band of monoclinic phase CuO nanoparticles were synthesized and calcined at 450 ºC, and the particle size of the nanoparticles was found to be in the range of 19-23 nm. These sizes of integrated CuO nanoparticles is a cost-efficient, biological molecule capable of working with antibiotics against Staphylococcus saprophyticus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli.

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Antibacterial Activity and Cytocompatibility of PLGA/CuO Hybrid Nanofiber Scaffolds Prepared by Electrospinning

Cited by 60 publications

References 35 publications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Flux Enhancement in Membrane Distillation Using Nanofiber Membranes

A Strains Activity of CuO Nanoparticles using Copper Chloride Dihydrate by Sol-Gel Method

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