Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3

Abstract

Selected aspects of the biological activity of a series of six nitrate silver(I) complexes with pyridine and (benz)imidazole derivatives were investigated. The present study evaluated the antibacterial activities of the complexes against three Gram-negative strains: Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922 and Proteus hauseri ATCC 13315. The results were compared with those of silver nitrate, a silver sulfadiazine drug and appropriate ligands. The most significant antibacterial properties were exerted by silver(I) complexes containing benzimidazole derivatives. The cytotoxic activity of the complexes was examined against B16 (murine melanoma) and 10T1/2 (murine fibroblasts) cells. All of the tested silver(I) compounds were not toxic to fibroblast cells in concentration inhibited cancer cell (B16) viability by 50%, which ranged between 2.44-28.65 µM. The molecular and crystal structure of silver(I) complex of 2,6-di(hydroxymethyl)pyridine was determined by single-crystal X-ray diffraction analysis. The most important features of the crystal packing and intermolecular non-covalent interactions in the Ag(I) complex were quantified via Hirshfeld surface analysis.

Metal complexes in cancer therapy – an update from drug design perspective

“…Silver complexes have been known for a long time for their antimicrobial activities63 and are widely used in the treatment of infected wounds and burn cases 63. In the past, silver complexes did not receive much attention compared to other metals,63 although silver complexes also demonstrated good cytotoxic activity against many cancer cell lines 63.…”

“…This way the DNA platination is increased with a resultant higher chance of apoptotic cell death 30. Just as ER targets platinum to the cancer cells expressing ER receptors, testosterone can target platinum to cancer cells expressing androgen receptor (AR) 30,63…”

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

“…The copper(II) complexes as well as the free ligands were microbiologically inactive and their absolute IC 50 values for B16 melanoma cells were high while the silver(I) complexes with the corresponding ligands demonstrated considerable both antimicrobial and cytotoxic activities. It may suggest that the presence of suitable metal ions is essential for microbiological and cytotoxic activity of complexes.…”

“…Silver(I) complexes with the corresponding ligands (Scheme ) have displayed the significant antimicrobial activity, whereas platinum(II) complexes of phosphate derivatives of pyridine occurred to be highly cytotoxic against A 549 (human non‐small lung cancer), HT 26 (human colorectal adenocarcinoma), and L 1210 (murine leukemia) cell lines . These positive results encouraged us to evaluate biological properties of copper(II) complexes with mentioned ligands from the group of phosphate or hydroxymethyl derivatives of heterocycles (Scheme ).…”

New Silver Complexes with Mixed Thiazolidine and Phosphine Ligands as Highly Potent Antimalarial and Anticancer Agents

“…e selectivity of Ag complexes towards the tumor cells was ligand-dependent, which could probably be attributable to the stability and hydrophilicity-lipophilicity of the complexes formed by the type of the ligand [61]. Interestingly, compound 2 was selective to inhibit the 50% of MDA-MB-231 cell growth (GI 50 � 1.9 ± 0.3 µM), while compound 5 acted more potent to inhibit breast carcinoma growth (GI 50 : MDA-MB-231 � 4.7 ± 1.1 µM; MCF-7 � 2.9 ± 0.9 µM) instead of colon carcinoma and HT-29 (GI 50 � 15.1 ± 1.9 µM).…”