Antibacterial activity and pharmacokinetic behaviour of cefazolin as compared with five other cephalosporin antibiotics

Naumann, P; Reintjens, E.

doi:10.1007/bf01642219

Cited by 20 publications

(7 citation statements)

References 4 publications

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“…The pharmacokinetic findings for the 3 cephalosporins tested show a good correlation with the data published by other authors [Bergeron et al, 1973;Gold et al, 1973;Kirby and Regamey, 1973;Naumann, 1973;Simon et al, 1973;Vomel and H offmann, 1974], Cefazolin distin guishes itself from the remaining cephalosporins by a more effective anti bacterial action against E. coli and Klebsiella [Ram and Watanatittan, 1973;Naumann, 1973;Sabath et al, 1973] as well as by clearly higher serum concentrations, a long serum half-life and a relatively low renal clearance. The meaning for chemotherapy of the high protein binding and the low apparent volume of distribution of cefazolin cannot, at the mo ment, be completely assessed.…”

Section: Discussionsupporting

confidence: 75%

Comparative Pharmacokinetics and Clinical Experience with a New Cephalosporin-Derivative: Cefazolin

Lode¹,

Gebert²,

Hendrischk³

1975

Chemotherapy

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In a cross-over study in 12 normal individuals, the pharmacokinetic parameters of cefalotin, cefradine and cefazolin were determined after intravenous injection of 1,000 mg of each substance. The microbiological activities in urine and serum were determined using the agar diffusion test; the pharmacokinetic data were calculated by a computer system on the basis of a Fortran programme. Cefazolin has significantly higher serum concentrations than the other two cephalosporins, distinctly longer serum half-lives, higher protein binding, and smaller apparent volumina of distribution. In 36 inpatients with mainly chronical and acute infections of the urinary tract, we tested the antibacterial effectivity, the compatibility, and the application modalities of cefazolin. In 29 patients we had a satisfactory clinical result, in 25 cases we achieved the elimination of bacteria by the end of the therapy. The compatibility of cefazolin was good; apart from a minor, reversible, liver-specific increase in enzymes in 6 patients, no side effects could be detected.

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Section: Discussionsupporting

confidence: 75%

Comparative Pharmacokinetics and Clinical Experience with a New Cephalosporin-Derivative: Cefazolin

Lode¹,

Gebert²,

Hendrischk³

1975

Chemotherapy

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“…Both drugs are mainly excreted unchanged in urine, the percentage in urine being 86% of the oral dose administered for cephradine ( . 1978) and 80% for an intravenous dose or cefazolin (Naumann & Reintjens 1974). In other respects, the two drugs are quite different.…”

Section: Discussionmentioning

confidence: 95%

“…In the present study we chose cephradine, which has a 14% protein binding (Finkelstein et al 1978;Singhvi et al 1977), and cefazolin, which is 84% protein bound (Craig et al 1973;Naumann & Reintjens 1974). These 2 drugs were the most appropriate for the indication when this study was conducted, although other, preferable cepha\osporins have recently been developed.…”

mentioning

confidence: 94%

Comparison of the Pharmacokinetics of Cephradine and Cefazolin in Pregnant and Non-Pregnant Women

Philipson

Stiernstedt

Ehrnebo

1987

Clinical Pharmacokinetics

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The pharmacokinetics of cephradine, a cephalosporin with a low degree of protein binding, was studied in 12 women after oral and intravenous administration of the drug during and after pregnancy. Six of the 12 women also received a cephalosporin with a high degree of protein binding, cefazolin, intravenously during and after pregnancy. For both drugs most pharmacokinetic parameters were altered in pregnancy. The area under the plasma concentration-time curve (AUC) following intravenous administration was smaller for both drugs during as compared to after pregnancy (mean change 39% for cephradine and 31% for cefazolin). Half-lives of both drugs were significantly shorter during compared with after pregnancy (mean change 26% for cephradine and 35% for cefazolin). Consequently, total body clearance was increased during pregnancy. A significant negative correlation between length of gestation and total clearance per kg bodyweight was seen for cephradine. The bioavailability of oral cephradine did not differ significantly during compared with after pregnancy. It is concluded that the dosage of both cefazolin and cephradine should be increased when treating infections in pregnant women in order to obtain the same antibacterial effect as when treating non-pregnant women.

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“…The zone of inhibition was then plotted against the logarithm of the antibiotic concentration, and the results were used to generate a computer program for the calculation of unknowns by the method of least squares. For ex- (3,6,13,18,30).…”

Section: Methodsmentioning

confidence: 99%

Blood, Brain, and Cerebrospinal Fluid Concentrations of Several Antibiotics in Rabbits with Intact and Inflamed Meninges

Beam

Allen

1977

Antimicrob Agents Chemother

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Because cerebrospinal fluid (CSF) antibiotic levels fail to predict either clinical success or relapse in the treatment of bacterial meningitis, we examined simultaneous antibiotic concentrations in the blood, brain, and CSF of control rabbits and of animals with experimental pneumococcal meningitis. Cefamandole pharmacokinetics were analyzed in detail and compared with those of cephalothin, ampicillin, penicillin G, and tobramycin. After 4 h of continuous intravenous infusion, cefamandole reached concentrations in both brain and CSF in excess of the minimal bactericidal concentration for the test organism and compared favorably with ampicillin and penicillin in achieving bacteriological cure. Cephalothin levels in the central nervous system remained undetectable in both control and infected animals during this time. Tobramycin concentrations were measurable in the CSF, but not in brain tissue in association with an inflammatory stimulus.

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Antibacterial activity and pharmacokinetic behaviour of cefazolin as compared with five other cephalosporin antibiotics

Cited by 20 publications

References 4 publications

Comparative Pharmacokinetics and Clinical Experience with a New Cephalosporin-Derivative: Cefazolin

Comparative Pharmacokinetics and Clinical Experience with a New Cephalosporin-Derivative: Cefazolin

Comparison of the Pharmacokinetics of Cephradine and Cefazolin in Pregnant and Non-Pregnant Women

Blood, Brain, and Cerebrospinal Fluid Concentrations of Several Antibiotics in Rabbits with Intact and Inflamed Meninges

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