Antibacterial activity and protective effect against gastric cancer by Anthriscus sylvestris fractions

Cho, Eun Ju; Choi, Ji Myung; Kim, Hye Min; Choi, Kyung; Ku, Ja-Jung; Park, Kwang-Woo; Kim, Jongkee; Lee, Sang‐Hyun

doi:10.1007/s13580-013-0170-3

Cited by 6 publications

(8 citation statements)

References 18 publications

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“…The antibacterial activities of the fractions were tested against Escherichia coli , Staphylococcus aureus , and Helicobacter pylori using the disc agar diffusion method. The n -hexane and methylene chloride fractions showed a stronger antibacterial activity against S. aureus than other fractions [112].…”

Section: Pharmacologymentioning

confidence: 99%

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

et al. 2015

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Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. Deoxypodophyllotoxin is considered to be the plant's most important constituent, because of its pharmacological properties and because it can be converted into epipodophyllotoxin, the main raw material for the semisynthesis of the cytostatic agents etoposide and teniposide. This work summarizes for the first time the results related to the botanical description, distribution and habitat, phytochemical and pharmacological properties and emphasizes the aspects for future biotechnological research to establish its utility in the therapeutic arsenal.

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Section: Pharmacologymentioning

confidence: 99%

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

et al. 2015

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“…The chemical composition of AN has been assessed in numerous phytochemical studies on all plant organs (leaves, flowers, and roots). The major classes of phytochemicals include monoterpenes, phenylpropanoids, coumarins, and flavonoid lignans [ 42 ]. Previous studies have reported that various fractions of AN extract may have a potent antimicrobial effect against pathogens and opportunistic bacteria such as Escherichia coli , Staphylococcus aureus , and Helicobacter pylori [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…The major classes of phytochemicals include monoterpenes, phenylpropanoids, coumarins, and flavonoid lignans [ 42 ]. Previous studies have reported that various fractions of AN extract may have a potent antimicrobial effect against pathogens and opportunistic bacteria such as Escherichia coli , Staphylococcus aureus , and Helicobacter pylori [ 42 ]. N -hexane, methylene chloride (MC), ethyl acetate, and butanol fractions were proven to have antibacterial roles, while n -hexane and MC fractions inhibited the growth of H. pylori and gastric adenocarcinoma cells [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have reported that various fractions of AN extract may have a potent antimicrobial effect against pathogens and opportunistic bacteria such as Escherichia coli , Staphylococcus aureus , and Helicobacter pylori [ 42 ]. N -hexane, methylene chloride (MC), ethyl acetate, and butanol fractions were proven to have antibacterial roles, while n -hexane and MC fractions inhibited the growth of H. pylori and gastric adenocarcinoma cells [ 42 ]. Furthermore, the antiproliferative effects of the roots and aerial part of AN showed a high in vitro inhibitory activity against MK-1, HeLa, and B16F10 tumor cell growth [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial, antifungal, antiviral, antioxidant, anticancer, and anti-inflammatory properties. However, their use is limited by their low water solubility and physicochemical stability. In order to overcome these limitations, we aimed to develop nanostructured carriers as delivery systems for plant extracts; in particular, we selected the extract of Anthriscus sylvestris (AN) on the basis of its antimicrobial effect and antitumor activity. In this study, AN-extract-functionalized magnetite (Fe3O4@AN) nanoparticles (NPs) were prepared by the co-precipitation method. The purpose of this study was to synthesize and investigate the physicochemical and biological features of composite coatings based on Fe3O4@AN NPs obtained by matrix-assisted pulsed laser evaporation technique. In this respect, laser fluence and drop-casting studies on coatings were performed. The physical and chemical properties of laser-synthesized coatings were investigated by scanning electron microscopy, while Fourier transform infrared spectroscopy comparative analysis was used for determining the chemical structure and functional integrity. Relevant data regarding the presence of magnetic nanoparticles as the only crystalline phase and the size of nanoparticles were obtained by transmission electron microscopy. The in vitro toxicity assessment of the Fe3O4@AN showed significant cytotoxic activity against human adenocarcinoma HT-29 cells after prolonged exposure. Antimicrobial results demonstrated that Fe3O4@AN coatings inhibit microbial colonization and biofilm formation in clinically relevant bacteria species and yeasts. Such coatings are useful, natural, and multifunctional solutions for the development of tailored medical devices and surfaces.

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“…Cell cycle arrest at this point leads to protein expression (cyclin A, B1, caspase 3,7), promoting apoptosis . DPT also shows promising anti-inflammatory (COX-1,2: IC 50 10 nM, 12 μM), antiviral (HSV-1,2:ED 50 4.0, 11 ng/mL vs acyclovir 50 ng/mL), antiallergy, antibacterial, and platelet aggregation inhibition activity . DPT development remains hampered by its scarcity of isolation from the mayapple plant A. silvestris and related species (232 mg/kg) .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Computational Studies Demonstrate the Utility of an Intramolecular Styryl Diels–Alder Reaction and Di-t-butylhydroxytoluene Assisted [1,3]-Shift to Construct Anticancer dl-Deoxypodophyllotoxin

et al. 2018

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Deoxypodophyllotoxin is a secondary metabolite lignan possessing potent anticancer activity with potential as a precursor for known anticancer drugs, but its use is limited by scarcity from natural sources. We here report the total synthesis of racemic deoxypodophyllotoxin in seven steps using an intramolecular styryl Diels-Alder reaction strategy uniquely suited to assemble the deoxypodophyllotoxin core. Density functional theory was used to analyze concerted, polar, and singlet-open-shell diradical reaction pathways, which identified a low-energy concerted [4 + 2] Diels-Alder pathway followed by a faster di-t-butylhydroxytoluene assisted [1,3]-formal hydrogen shift.

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Antibacterial activity and protective effect against gastric cancer by Anthriscus sylvestris fractions

Cited by 6 publications

References 18 publications

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Synthesis and Computational Studies Demonstrate the Utility of an Intramolecular Styryl Diels–Alder Reaction and Di-t-butylhydroxytoluene Assisted [1,3]-Shift to Construct Anticancer dl-Deoxypodophyllotoxin

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