Antibacterial activity, cytocompatibility, and thermomechanical stability of Ti40Zr10Cu36Pd14 bulk metallic glass

Evaluation of sustained drug release performance and osteoinduction of magnetron-sputtered tantalum-coated titanium dioxide nanotubes

“…[1][2][3][4] However, the antibacterial scarcity, poor osteo-induction ability, and potential allergic reaction of titanium implants may cause postoperative complications, thus, leading to premature implant loss. 3,[5][6][7] Moreover, titanium-based implants can be easily modied by physical, chemical, and biological techniques. [8][9][10] In addition, with these surface modications, both surface energy and osteogenesis could be promoted.…”

Anticorrosion and Antimicrobial Tannic Acid-Functionalized Ti-Metallic Glass Ribbons for Dental Abutment

“…However, a disadvantage to the two-piece dental implant can be the existence of poor sealing along the implant body-abutment interface, providing a potential site for colonization of bacterial pathogens consisting of oral pathogens like Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, or other pathogens, for example, Staphylococcus aureus and Pseudomonas aeruginosa transferred from anterior nares or skin. , The literature has reported the migration of bacteria into the internal part of the bone implant through such a microgap and micromovement of the implant-abutment, causing interference with the health of the preimplant tissue, inflammation, and bone loss. , To avoid dental implant loss due to infection and inflammation response, some antibiotics like prophylaxis were prescribed to a patient immediately after dental surgery or amoxicillin 1 h before dental surgery. , Therefore, the development of new biomaterials without containing any toxic ions and modifying their surface properties can prevent an increased number of antibiotic-resistant bacteria due to the routine consumption of antibiotics before or after surgery. Sarac et al demonstrated that titanium-based metallic glasses (MGs) outperform the gold-standard Ti–6Al–4V when used as dental implants. , Yet, the development of titanium-based metallic glasses devoid of potentially toxic metals is imperative to mitigate any potential inflammatory reactions within the body . In light of this, titanium-based bulk metallic glasses (BMGs) have emerged as promising implant materials due to their advantageous engineering properties such as low elastic modulus, high strength, toughness, corrosion resistance and, in some cases, even intrinsic antibacterial properties, superior to conventional crystalline Ti-alloys. ,− Consequently, numerous Ti-based BMGs have been reported, exhibiting favorable characteristics compared to traditional crystalline Ti-based alloys. , Nevertheless, many of these BMGs contain elements like Ni, Cu, and/or Be, which are known to be harmful to the human body due to their cytotoxicity. ,− ,− As a result, their inclusion limits the application of Ti-based BMGs in the medical field.…”

“…Sarac et al demonstrated that titanium-based metallic glasses (MGs) outperform the gold-standard Ti–6Al–4V when used as dental implants. , Yet, the development of titanium-based metallic glasses devoid of potentially toxic metals is imperative to mitigate any potential inflammatory reactions within the body . In light of this, titanium-based bulk metallic glasses (BMGs) have emerged as promising implant materials due to their advantageous engineering properties such as low elastic modulus, high strength, toughness, corrosion resistance and, in some cases, even intrinsic antibacterial properties, superior to conventional crystalline Ti-alloys. ,− Consequently, numerous Ti-based BMGs have been reported, exhibiting favorable characteristics compared to traditional crystalline Ti-based alloys. , Nevertheless, many of these BMGs contain elements like Ni, Cu, and/or Be, which are known to be harmful to the human body due to their cytotoxicity. ,− ,− As a result, their inclusion limits the application of Ti-based BMGs in the medical field. Hence, the pursuit of new glass-forming alloys without potentially toxic elements becomes imperative to effectively harness Ti-based metallic glasses for implant materials.…”

Hierarchical Surface Pattern on Ni‐Free Ti‐Based Bulk Metallic Glass to Control Cell Interactions

“…[1][2][3] In addition, owing to their amorphous nature, Ti-BMGs have attractive properties such as high corrosion resistance, wear resistance, lower Young's modulus, higher elasticity, and higher specific strength than traditional crystalline Ti-alloys, making them potential biomaterials for dental and orthopedic applications. [2][3][4][5][6][7] The reduced Young's modulus and enhanced elastic behavior are expected to alleviate stress-shielding effects when contacting bone tissues. [8,9] Indeed, many efforts have been devoted to the development of 𝛽-type titanium alloys achieving low Young's modulus below 80 GPa for crystalline materials.…”