Antibacterial Activity in Vitro of Fucidin

Barber, Mary; Waterworth, Pamela M.

doi:10.1016/s0140-6736(62)91969-4

Cited by 72 publications

(33 citation statements)

References 2 publications

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“…According to other workers (Godtfredsen et al, 1962;Barber and Waterworth, 1962;Scowen and Garrod, 1962; Taylor and Bloor, 1962) a mixture of fucidin and penicillin G acts synergistically upon large inocula of certain strains of Staph. aureus.…”

Section: Discussionmentioning

confidence: 93%

“…Reports have recently been published on the laboratory (Godtfredsen et al, 1962;Barber and Waterworth, 1962;Hilson, 1962) and preliminary clinical (Scowen and Garrod, 1962;Taylor and Bloor, 1962) attributes of fusidic acid and its sodium salt (" fucidin "). In its chemical structure, relationship to cephalosporin P (Baird et al, 1961) and helvolic acid (Allinger and Coke, 1961), and in its selective antibacterial spectrum, this substance is of considerable interest.…”

Section: G T Stewart MDmentioning

confidence: 99%

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Fusidic Acid: Laboratory and Clinical Assessment

1963

JAMA

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Section: Discussionmentioning

confidence: 93%

Section: G T Stewart MDmentioning

confidence: 99%

Fusidic Acid: Laboratory and Clinical Assessment

1963

JAMA

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“…Both synergy and antagonism have been reported for combinations of fusidic acid and penicillins (Barber and Waterworth, 1962;Jensen and Kiaer, 1964;Mouton and Koelrnan, 1966;Jensen and Lassen, 1969). Synergy has been attributed to penicillinase-producing cells being suppressed by fusidic acid, and variants genotypically resistant to fusidic acid being killed by the penicillin.…”

Section: Discussionmentioning

confidence: 98%

“…Barber and Waterworth (1962) showed synergy between fusidic acid and benzylpenicillin in certain circumstances, and Jensen and Kiaer (1964) confirmed this, as well as reporting synergy with other agents including methicillin. On the other hand, other workers (Mouton and Koelman, 1966;Jensen and Lassen, 1969) have found antagonism against some strains of staphylococci between fusidic acid and methicillin and sometimes other penicillins including benzylpenicillin.…”

Section: Plates XVII and Xviiimentioning

confidence: 90%

Interactions Between Fusidic Acid and Penicillins

O'Grady

Greenwood

1973

Journal of Medical Microbiology

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PLATES XVII AND XVIIIFUSIDIC A C I D is a potent bactericidal antistaphylococcal agent, but one of its drawbacks is the presence in any staphylococcal population exceeding about lo6 cells of genotypically resistant variants that might proliferate during fusidic acid therapy. Because of this, combinations of fusidic acid with other antistaphylococcal agents have been recommended and penicillins have figured largely amongst those chosen. The wisdom of this choice has been questioned because antagonism has been demonstrated in vitro between fusidic acid and penicillins.Reports in the literature of possible interactions between fusidic acid and penicillins are conflicting. Barber and Waterworth (1962) showed synergy between fusidic acid and benzylpenicillin in certain circumstances, and Jensen and Kiaer (1964) confirmed this, as well as reporting synergy with other agents including methicillin. On the other hand, other workers (Mouton and Koelman, 1966;Jensen and Lassen, 1969) have found antagonism against some strains of staphylococci between fusidic acid and methicillin and sometimes other penicillins including benzylpenicillin.The present study was undertaken in an attempt to clarify the situation in view of the increasing frequency with which combinations of fusidic acid and penicillins are being used in antistaphylococcal therapy. MATERIALS AND METHODSStrains of coagulase-positive Staphylococcus aureus were taken at random from those isolated in the diagnostic laboratory of the hospital. Both penicillin-sensitive and penicillinase-producing strains that were sensitive on routine testing to fusidic acid and methicillin were included. Strains were designated by the first three letters of the name of the patient from whom they had been isolated, e.g. Col.The minimum inhibitory concentration (MIC) of the antibiotics for the strains was determined by a conventional serialdilution tube titration with small inoculum (c. 104-105 organisms per ml). Turbidimetric studies were made by inoculating 15 ml of nutrient broth with the test organism and incubating the continuously mixed culture in the light path of a simple photometer (Watson et al., 1969) housed in an incubator at 3 7 ' C and connected to a continuous recorder. The system will respond to bacterial concentrations in excess of lo6 per ml. Antibiotic was added when an opacity corresponding with a viable count of about 5 x lo7 organisms per ml had been reached. The number of survivors recoverable after incubating the organism overnight in broth with the various agents alone and in combination was determined by filtering the cultures

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“…Fusidik asit ABD'de lisanslı olmadığından, NCCLS önerileri içinde duyarlılık sınırına dair değer bulunmamaktadır (6). Ancak gerek İngiliz Antimikrobiyal Kemoterapi Derneği (BSAC), gerek Fransa Mikrobiyoloji Derneği, gerekse bu konuda standart oluş-turmak amacıyla yapılmış çalışmalar fusidik asit'in stafilokoklar için MİK değerlerini duyarlı, orta duyarlı ve dirençli olmak üzere sırasıyla; ≤0.125 mg/L, 0.5-1 mg/L ve ≥2 mg/L olarak bildirmektedir (8)(9)(10) 1962 yılında İngiltere'de yapılan iki çalışmada toplam 150 S.aureus suşunun 147'sinin (%98) fusidik asite duyarlı (MİK≤0.125mg/L), 3'ünün (%2) ise orta duyarlı oldukları (MİK=0.5mg/L) bildirilmiştir (15,16). Aradan geçen 40 yılı aşkın sürede fusidik asitin stafilokoklara karşı etkinliğini koruduğu görülmektedir.…”

Section: Discussionunclassified

Fusidik asidin Staphylococcus aureus suşlarına karşı in-vitro etkinliği In-vitro activitiy offusidic acid against Staphylococcus aureus

Alpay;AYGÜN¹

2005

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Amaç: Bu çalışmada klinik örneklerden izole edilen ve enfeksiyon etkeni olarak kabul edilen 440 Staphylococcus aureus suşunun fusidik asite in-vitro duyarlılığı araştırılması amaçlandı. Gereç ve yöntem: "National Committee for Clinical Laboratory Standards" (NCCLS) önerileri doğ-rultusunda agar dilüsyon yöntemi ile minimal inhibitör konsantrasyon (MİK) değerleri belirlendi. MİK değeri ≥2 mg/L olan suşlar dirençli, ≤0.125mg/L olan suşlar duyarlı kabul edildi. Bulgular: Çalışmaya alınan 196 metisiline duyarlı S.aureus suşunda fusidik asite direnç saptanmazken, 244 metisiline dirençli S.aureus suşundan 2'si (%0.8) fusidik asite dirençli bulundu. Sonuç: Fusidik asit, metisiline dirençli ve duyarlı stafilokokların etken olduğu enfeksiyonlarda iyi bir tedavi seçeneği olarak karşımıza çıkmaktadır. Anahtar sözcükler: Staphylococcus aureus, fusidik asitAim: This study was undertaken to investigate the in vitro susceptibility of Staphylococcus aureus strains to fusidic acid. Materials and methods: A total of 440 strains isolated from various clinical specimens were included in the study. The susceptibility tests were performed by agar dilution method acccording to the NCCLS (National Committee for Clinical Laboratory Standards) criteria. Strains with MIC value of ≥2 mg/L were taken as resistant to fusidic acid. Results: None of the methicillin-susceptible S.aureus (MSSA) strains were found to be resistant while 2 (0.8%) of 244 methicillin-resistant S.aureus (MRSA) strains were resistant to fusidic acid. Conclusion: Fusidic acid can be considered as an alternative drug for the treatment of infections due to both methicillin susceptible and resistant S.aureus strains.

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Antibacterial Activity in Vitro of Fucidin

Cited by 72 publications

References 2 publications

Fusidic Acid: Laboratory and Clinical Assessment

Fusidic Acid: Laboratory and Clinical Assessment

Interactions Between Fusidic Acid and Penicillins

Fusidik asidin Staphylococcus aureus suşlarına karşı in-vitro etkinliği In-vitro activitiy offusidic acid against Staphylococcus aureus

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