Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors

Mumyatova, V. A.; Козуб, Г. И.; Kondrat'eva, T. A.; Терентьев, А. А.; Санина, Н. А.

doi:10.1007/s11172-019-2514-3

Cited by 15 publications

(7 citation statements)

References 25 publications

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“…Three DNIC dimers with 5-(nitrophenyl)-4-H-1,2,4-triazole-3-thiolyls exhibited an equal growth-inhibiting effect on M. luteus and E. coli and inhibited biofilm formation at a wide range of concentrations [ 10 ]. As was found for complex I , DNICs with nitrothiophenols or dimethylthiourea [ 9 ] and 5-(nitrophenyl)-4-H-1,2,4-triazole-3-thiolyls [ 10 ], the antibiofilm activity of DNICs is comparable to that of antibiotics. Thus, DNICs of different structures exert antibacterial activity.…”

Section: Discussionsupporting

confidence: 56%

“…Being effective low-toxic exogenous nitric oxide (NO) donors complementary to a human organism, low-molecular dinitrosyl complexes of tetrahedral iron involving two nitrosyl and two sulfur-containing ligands, as structural analogs of the active sites of dinitrosyl [1Fe-2S] proteins, are promising for practical application in medicine, which is the reason for the increasing interest in fundamental studies of their structural features [ 3 , 4 , 5 ]. As follows from our investigations, the activity of dinitrosyl complexes of tetrahedral iron (DNICs) and their dimers ( Figure 1 A,B) as antibacterial agents is comparable and/or higher than that of antibiotics used in clinics [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 55%

“…Comparison of the antibacterial, cytotoxic and NO-donating properties of complex I and DNICs with thiolyls studied earlier [ 9 , 10 , 42 , 43 , 44 ] leads to some important points.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous work, sixteen nitrosyl iron complexes were found to inhibit the growth of gram-positive bacteria and, with less efficacy, gram-negative bacteria. Most of these complexes were efficient inhibitors of biofilm formation [ 9 ]. Three DNIC dimers with 5-(nitrophenyl)-4-H-1,2,4-triazole-3-thiolyls exhibited an equal growth-inhibiting effect on M. luteus and E. coli and inhibited biofilm formation at a wide range of concentrations [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL’2(NO)2][FeL’L”(NO)2] with L’-thiobenzamide and L”-thiosulfate

et al. 2022

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In this work a new donor of nitric oxide (NO) with antibacterial properties, namely nitrosyl iron complex of [Fe(C6H5C-SNH2)2(NO)2][Fe(C6H5C-SNH2)(S2O3)(NO)2] composition (complex I), has been synthesized and studied. Complex I was produced by the reduction of the aqueous solution of [Fe2(S2O3)2(NO)2]2− dianion by the thiosulfate, with the further treatment of the mixture by the acidified alcohol solution of thiobenzamide. Based on the structural study of I (X-ray analysis, quantum chemical calculations by NBO and QTAIM methods in the frame of DFT), the data were obtained on the presence of the NO…NO interactions, which stabilize the DNIC dimer in the solid phase. The conformation properties, electronic structure and free energies of complex I hydration were studied using B3LYP functional and the set of 6–31 + G(d,p) basis functions. The effect of an aquatic surrounding was taken into account in the frame of a polarized continuous model (PCM). The NO-donating activity of complex I was studied by the amperometry method using an “amiNO-700” sensor electrode of the “inNO Nitric Oxide Measuring System”. The antibacterial activity of I was studied on gram-negative (Escherichia coli) and gram-positive (Micrococcus luteus) bacteria. Cytotoxicity was studied using Vero cells. Complex I was found to exhibit antibacterial activity comparable to that of antibiotics, and moderate toxicity to Vero cells.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 55%

“…Comparison of the antibacterial, cytotoxic and NO-donating properties of complex I and DNICs with thiolyls studied earlier [ 9 , 10 , 42 , 43 , 44 ] leads to some important points.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL’2(NO)2][FeL’L”(NO)2] with L’-thiobenzamide and L”-thiosulfate

et al. 2022

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“…Speaking to the vast library of DNICs, Sanina and coworkers tested sixteen different DNICs that utilize a range of thiophenolate- to thiourea-based ligands against gram positve and negative bacteria, looking for antibacterial effects. They found that these DNICs have comparable effects to other NO donors, with [(μ-SC 6 H 4 - m -OH) 2 Fe 2 (NO) 4 ] ( 190 ) having the greatest cytotoxic effects …”

Section: Dinitrosyl Iron Complexes (Dnics)mentioning

confidence: 99%

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

et al. 2021

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Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of physiological and pathological events in biology. Metal coordination chemistry, especially with iron, is at the heart of many biological transformations involving NO. A series of heme proteins, nitric oxide synthases (NOS), soluble guanylate cyclase (sGC), and nitrophorins, are responsible for the biosynthesis, sensing, and transport of NO. Alternatively, NO can be generated from nitrite by heme- and copper-containing nitrite reductases (NIRs). The NO-bearing small molecules such as nitrosothiols and dinitrosyl iron complexes (DNICs) can serve as an alternative vehicle for NO storage and transport. Once NO is formed, the rich reaction chemistry of NO leads to a wide variety of biological activities including reduction of NO by heme or non-heme iron-containing NO reductases and protein post-translational modifications by DNICs. Much of our understanding of the reactivity of metal sites in biology with NO and the mechanisms of these transformations has come from the elucidation of the geometric and electronic structures and chemical reactivity of synthetic model systems, in synergy with biochemical and biophysical studies on the relevant proteins themselves. This review focuses on recent advancements from studies on proteins and model complexes that not only have improved our understanding of the biological roles of NO but also have provided foundations for biomedical research and for bio-inspired catalyst design in energy science.

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Synthesis, properties, and antibacterial activity of a new nitric oxide donor — a nitrosyl iron complex with 5-phenyl-1H-1,2,4-triazole-3-thiol

et al. 2019

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Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors

Cited by 15 publications

References 25 publications

Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL’2(NO)2][FeL’L”(NO)2] with L’-thiobenzamide and L”-thiosulfate

Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL’2(NO)2][FeL’L”(NO)2] with L’-thiobenzamide and L”-thiosulfate

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

Synthesis, properties, and antibacterial activity of a new nitric oxide donor — a nitrosyl iron complex with 5-phenyl-1H-1,2,4-triazole-3-thiol

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