Antibacterial Activity of a Series of Diphenylmethanes *

Florestano, H. J.; Bahler, M.E.

doi:10.1002/jps.3030420916

Cited by 9 publications

(4 citation statements)

References 9 publications

(3 reference statements)

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“…Although this difference may reflect cell clumping or other causes, it seemed possible that the materials released at early stages might be qualitatively different from those released later. Comparison of absorption spectra, however, revealed greater, but still proportional, differences in intensity after 7 hr of treatment. Similar curves were obtained in comparing materials released from cells treated with HCP with those released from untreated cells.…”

Section: Resultsmentioning

confidence: 82%

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Antimicrobial Actions of Hexachlorophene: Release of Cytoplasmic Materials

1971

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Intracellular solutes were released from growing or resting cells of Bacillus megaterium as a consequence of hexachlorophene treatment. The effect was dose dependent, with the optimum at a concentration about sevenfold greater than the minimal lethal dose. The effects of pH and temperature on the leakage process also were inconsistent with the killing effects of the drug. The types of materials released appeared to be the same with or without hexachlorophene treatment. The released materials were smrall molecules which apparently derived from preexisting ribonucleic acid and protein, but not from deoxyribonucleic acid. Compared to the effects of other representative surface-active agents and other bis-phenols, hexachlorophene was superior in ability to cause leakage of intracellular materials. Different microorganisms varied in their susceptibility to hexachlorophene, with Pseudomonas aeruginosa and a paracolon isolate the most resistant of the vegetative cells examined. It was concluded that the release of intracellular solutes was an effect secondary to the lethal event and presumably arose from hexachlorophenemediated stimulation of degradative enzymes.

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Section: Resultsmentioning

confidence: 82%

“…HCP also was compared with a series of substituted bis-phenols which have been studied in efforts to correlate molecular structure with biological activity (3,7,8). All of the bis-phenols were used at a final concentration of 2.4 x 104 M, corresponding to 100 Mg of HCP per ml.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Actions of Hexachlorophene: Release of Cytoplasmic Materials

1971

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“…MN05 belongs to the monohydroxydiphenylmethane class of compounds that are known for their bactericidal activity (Florestano & Bahler, ; Klarmann, Gates, & Shternov, ). However, bacterial targets for such compounds have never been identified and it is the first time to report FabI as a drug target for them.…”

Section: Resultsmentioning

confidence: 99%

Structure‐based drug design and in vitro testing reveal new inhibitors of enoyl‐acyl carrier protein reductases

et al. 2019

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The need for new antibacterial agents is increasingly becoming of great importance as bacterial resistance to current drugs is quickly spreading. Enoyl‐acyl carrier protein reductases (FabI) are important enzymes for fatty acid biosynthesis in bacteria and other micro‐organisms. In this project, we conducted structure‐based virtual screening against the FabI enzyme, and accordingly, 37 compounds were selected for experimental testing. Interestingly, five compounds were able to demonstrate antimicrobial effect with variable inhibition activity against various strains of bacteria and fungi. Minimum inhibitory concentrations of the active compounds were determined and showed to be in low to medium micromolar range. Subsequently, enzyme inhibition assay was carried out for our five antimicrobial hits to confirm their biological target and determine their IC50 values. Three of these tested compounds exhibited inhibition activity for the FabI enzyme where our best hit MN02 had an IC50 value of 7.8 μM. Furthermore, MN02 is a small bisphenolic compound that is predicted to have all required features to firmly bind with the target enzyme. To sum up, hits discovered in this work can act as a good starting point for the future development of new and potent antimicrobial agents.

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“…In Aloe vera, fumaric acid which is an organic acid has been reported as antibacterial component [113]. A series of diphenyl methane compounds display antimicrobial action against various microorganisms [114]. In Malaysian Mangifera indicakernel, Phenol, 2, 4-Bis (1, 1-Dimethyl ethyl) was identified and reported to have antibacterial activity [115].…”

Section: Mode Of Action Of Plant Secondary Metabolitesmentioning

confidence: 99%

Phytochemicals and Their Antimicrobial Activity: An Update on Their Mode of Action

Pammi¹,

Giri²

2021

IJCEMR

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Introduction: Plants have been considered as potential alternative for antimicrobial antibiotics owing to vast reserve of secondary metabolites. Last few decades have experienced an upsurge in demand and delivery of herbal products for health benefits as plant derived bioactive compounds have capability to interact with a wide variety of targets. The main focus of this review was to congregate vital information related to imperative bioactive components of medicinal plants having therapeutic potential with particular reference to antimicrobial activity against pathogenic bacteria. Our study intended to comprehend the mode of action of these phytopharmaceuticals for their scientific validation and drug development. Methods: A narrative review of papers reporting antimicrobial activity of medicinal plants against pathogenic bacteria, identification of the prospective bioactive compounds with antimicrobial potential and understanding their mechanism of action has been envisaged. Results: This review includes anthology of recent published information on phytoconstituents of various medicinal plants belonging to different families around the globe, tested and validated against various pathogenic bacteria. This study unveils the treasure of antimicrobial potential of plant species, which is also an appraisal of information related to mechanism of action of these phytochemicals required for their antimicrobial activity. Conclusions: There is resurgence in use of herbal medicines and identification of pharmacologically active compounds with their scientific validation. It will play a pivotal role in perpetuating and promoting wider usages of drugs based on plant extracts. A missing link for establishment of phytocompounds as an alternative drug requires understanding their mode of action and exploitation.

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Antibacterial Activity of a Series of Diphenylmethanes *

Cited by 9 publications

References 9 publications

Antimicrobial Actions of Hexachlorophene: Release of Cytoplasmic Materials

Antimicrobial Actions of Hexachlorophene: Release of Cytoplasmic Materials

Structure‐based drug design and in vitro testing reveal new inhibitors of enoyl‐acyl carrier protein reductases

Phytochemicals and Their Antimicrobial Activity: An Update on Their Mode of Action

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