Antibacterial Activity of Aegopodium podagraria L. Extracts and Interaction Between Extracts and Antibiotics

Stefanović, Olgica D.; Comic, Ljiljana; Stanojević, Dragana; Sukdolak, Slavica Solujic

doi:10.3906/biy-0810-21

Cited by 20 publications

(14 citation statements)

References 7 publications

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“…Nesse contexto, é relatado por Stefanovic et al (2012), que substâncias diferentes combinadas aumentam as chances de conter uma infecção, e que a utilização de extratos de espécies vegetais bioativas, derivados semissintéticos e substâncias puras isoladas ampliam a eficácia in vitro de antimicrobianos empregados contra uma diversidade de microrganismos.…”

Section: Efeito Da Fração Vm-f19-20 Sobre a Cinética Do Crescimento M...unclassified

Biological and phytochemical study of the leaves of Verbesina macrophylla (Cass.) S.F. Blake (Asteraceae)

Deiró,

Vale,

Boness

et al. 2023

CLIUM

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Verbesina macrophylla is used in folk medicine to treat infections, inflammation and fever. This work aimed to evaluate the biological activity and phytochemistry of the species. Extracts in hexane, ethyl acetate and ethanol from the leaves of V. macrophylla revealed, using the microdilution method, activity against Gram positive bacteria (B. cereus, S. aureus, B. subtilis and M. luteus), with Inhibitory Concentration Minimum (MIC) between 500 µg/mL and 7.81 µg/mL. Fractionation of the extract in ethyl acetate resulted in 51 samples, all inactive for Gram-negatives. Four fractions showed activity against C. albicans and two against A. niger, at a concentration of 1000 µg/mL. Analysis of NMR data from fraction 19-20 revealed the presence of two isomers: (6-O-b-E-p-coumaroyl-4a-hydroxyeudesmane and 6-O-b-Z-p-coumaroyl-4a-hydroxyeudesmane), active for all Gram positive bacteria, bactericidal for B. cereus and S. aureus, with MIC between 2.5 and 3.9 µg/mL. The cytotoxicity test on red blood cells of the extracts showed slight hemolysis only for the hexane extract. The kinetic study of microbial growth of the Vm F19-20 fraction using the time-kill method revealed a dose-dependent effect for the B. subtilis strain.

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Section: Efeito Da Fração Vm-f19-20 Sobre a Cinética Do Crescimento M...unclassified

Biological and phytochemical study of the leaves of Verbesina macrophylla (Cass.) S.F. Blake (Asteraceae)

Deiró,

Vale,

Boness

et al. 2023

CLIUM

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“…Common goutweed (Aegopodium podagraria L.), a member of the Apiaceae family, is a common perennial plant found all around the world, including Europe, North America, and Asia [1,2]. It spreads readily via creeping rhizomes and stolons, as well as being frost hardy.…”

Section: Introductionmentioning

confidence: 99%

“…Infusions made from dried leaves are recommended to remedy gout, haemorrhoids, inflammatory conditions of the kidneys and bladder, as an auxiliary treatment for kidney stone disease, and to improve metabolism. Fresh leaves can be put on wounds to facilitate healing [1][2][3]. Apart from its medicinal properties, goutweed is also an edible plant.…”

Section: Introductionmentioning

confidence: 99%

“…Goutweed leaves contain polyacetylenes, including falcarinol and falcarindiol, essential oils, chiefly mono-and sesquiterpenes, vitamins, as well as macro-and microelements, notably iron, copper, manganese, titanium, boron, calcium and potassium [3][4][5]. Phenolic compounds, including coumarins, phenolic acids, and flavonoids, can also be found in goutweed [1][2][3][4][5]. Falcarinol and falcarindiol are the main biologically active compounds naturally occurring in plants of the Apiaceae family, both wild, e.g., goutweed, and in vegetables such as carrots, parsley, and celery.…”

Section: Introductionmentioning

confidence: 99%

“…Its concentration-dependent antioxidant properties have also been demonstrated [6,7]. According to the available literature, Aegopodium podagraria is safe to use [1][2][3]. This is because of the wide margin between the therapeutic and toxic dose of the main active compound in the plant (falcarinol), which makes it possible to use the product without the risk of adverse effects [4].…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

et al. 2021

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Aegopodium podagraria L. (goutweed), a member of the Apiaceae family, is a common perennial plant found all around the world that has been used in folk medicine since antiquity. Goutweed leaves contain polyacetylenes, essential oils, mono- and sesquiterpenes, vitamins, macro- and microelements, and phenolic compounds. In spite of its many health-promoting properties, including antioxidant effects, the plant has not been thoroughly studied. The aim of this study was to investigate the antioxidant properties of different goutweed leaf extracts and their effects on the THP-1 cell line, and also to describe the chemical characteristics of goutweed. Falcarinol and falcarindiol and essential oil were determined by gas chromatography coupled with mass spectrometry. Spectrophotometry was used to measure the total content of polyphenols and antioxidant activity–by DPPH and FRAP methods. Oxidative stress in THP-1 cells was induced via sodium fluoride. Then, goutweed leaf extracts were added to evaluate their influence on antioxidant potential (ABTS) and the activity of antioxidant enzymes. Confocal microscopy was used to visualise the production of cytoplasmic and mitochondrial reactive oxygen species (ROS) and for in vitro imaging of apoptosis. The ethanol extracts have a high total content of polyphenols, polyacetylenes, and essential oil, as well as high antioxidant potential. The main volatiles represented diverse chemical groups, which are both oxygenated derivatives of sesquiterpenes and monoterpenes. We also demonstrated positive effects of the high antioxidant potential and increased activity of antioxidant enzymes on cell cultures under severe fluoride-induced oxidative stress. Extraction at 80 ℃ and the use of ethanol as a solvent increased the antioxidant capacity of the extract. The leaves of Aegopodium podagraria may serve as a valuable source of antioxidants in the daily diet and assist in the prevention and treatment of oxidative stress-mediated conditions, e.g., inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, and even obesity.

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Karadeni̇z Bölgesi̇’ni̇n Yeni̇lebi̇li̇r Otlarinin Fonksi̇yonel Gidalar Kapsaminda Değerlendi̇ri̇lmesi̇

SARICA,

ÖZBAY

2023

Adıyaman Üniversitesi Sosyal Bilimler Enstitüsü Dergisi

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Fonksiyonel gıdalar içeriğindeki bileşenler, minareller, vitaminler, aminoasitler, baharatlar, bitkiler bakımından insan sağlığı için önem arz etmektedir. Yeşil yapraklı bitkiler de işlevsel özelliklere sahip, iyi bir A vitamini kaynağı, flavonoidler ve karotenoidler bakımından zengin besinlerdir. Bu araştırmanın temel amacı; Karadeniz Bölgesi’nin yenilebilir otlarının fonksiyonel gıdalar kapsamında değerlendirilip değerlendirilemeyeceğini belirlemektir. Bu amaç doğrultusunda literatür taraması yapılarak Karadeniz Bölgesi’nin 17 adet yenilebilir otu incelenmiş, otların besin değerleri, mutfaklarda kullanım şekilleri, sağlık için faydaları, hastalık tedavilerinde kullanım şekilleri içeriğindeki vitamin, minarel ve ağır metaller hakkında bilgi verilmiştir. Araştırma sonucunda Karadeniz’in yenilebilir otlarının insan sağlığı üzerinde olumlu etkilerinin olması, hastalık önlemesi ve hastalık tedavisinde kullanılması gerekçeleriyle fonksiyonel gıdalar kapsamında değerlendirebileceği sonucuna varılmıştır.

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Antibacterial Activity of Aegopodium podagraria L. Extracts and Interaction Between Extracts and Antibiotics

Cited by 20 publications

References 7 publications

Biological and phytochemical study of the leaves of Verbesina macrophylla (Cass.) S.F. Blake (Asteraceae)

Biological and phytochemical study of the leaves of Verbesina macrophylla (Cass.) S.F. Blake (Asteraceae)

Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line

Karadeni̇z Bölgesi̇’ni̇n Yeni̇lebi̇li̇r Otlarinin Fonksi̇yonel Gidalar Kapsaminda Değerlendi̇ri̇lmesi̇

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