Antibacterial Activity of Amphiphiles Based on Indolyl-3-Carboxylic Acids and L-Lysine With Ethylenediamine Linker

Abstract

Recently, due to the growth of bacterial infections resistant to antibiotics, there is an urgent need to develop alternative antibacterial drugs. Alkyl-indolyl-L-lysine is a promising class of compounds; their amphiphilic structure is key in antimicrobial ef cacy. A scheme was developed and the synthesis of ve new derivatives of indolylbutyric and indolylacetic acids containing a polar amino acid residue with an ethylenediamine linker binding alkyl fragments of different lengths was carried out. The antibacterial activity of new amphiphiles against gram-positive and gram-negative bacterial strains was evaluated. The minimum binding energy of synthesized compounds with human serum albumin (HSA) was determined by the method of molecular docking. A lower af nity of the studied objects was shown compared to the control indolmycin.