Antibacterial activity of Ampicillin trihydrate formulated in Aluminium-Magnesium Silicate, against <i>Salmonella gallinarum</i>

Abstract

ABSTRACT

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

“…The Synthetic AMS improved effect of Ampicillin at all dose levels tested in this experiment, but only its effect at 7.5 mg/kg, in combination with feeds with immune-stimulating levels of vitamins A, C, E, and Selenium produced antimicrobial cure (95% infection clearance). That when antimicrobial drugs are stabilized with aluminum-magnesium silicate, best effects are got with 75% of their normal doses, has been consistent [22][23][24][25].…”

“…Reducing dose of Ampicillin to 7.5 mg/kg, in combination with the fortified feed, improved the bacterial clearance to 104400.00 ± 36024.44 CFU/ml giving a better reduction in infection rate, of 87.3% from the 72.2% got with 10 mg/kg. This suggests that reducing dose of Ampicillin may have minimized side effect of the drug [23] and so immune response of the chicks was further enhanced. When the dose was further reduced to 5 mg/kg, the infection rate (198400.00 ± 129301.80 CFU/ml) was only 75.9% reduction which is less effective than that got at 7.5 mg/kg.…”

“…Stabilizing agents protect drugs from rapid degradation by metabolic processes and aluminum-magnesium silicate is used to stabilize drugs [13]. It has been used to stabilize Ampicillin and that enhanced the antibiotic's ability to clear Salmonella gallinarum infection in chicks, from 69.2% to 97.8% [23]. So, the improved clearance of E. coli infection rate by as much as 95.8% got in the group treated at dose of 7.5 mg/kg with Ampicillin stabilized in The Synthetic AMS in this experiment could be attributed to ability of the AMS to prolong bioavailability of Ampicillin in the treated chicks.…”

“…The Synthetic AMS has been used for in vivo experiments with chicks, dogs, mice and rats [18][19][20][21][22][23][24][25] without adverse side effects on treated animals. It may therefore be possible to minimize immune suppression due to Ampicillin [1] by reducing its dose and use The Synthetic AMS to improve antibacterial activity of the lower doses.…”

Aluminum-Magnesium Silicate enhances release of virions of cultured <i>Fowl Pox Virus</i> and inhibits the virus

“…So, AMS is made of Nanoparticles [14] which have been reported to selectively deliver drugs to cancer cells [15]. The Synthetic AMS used in this study has been used for in vivo treatment of chicks, dogs, mice and rats [16][17][18][19][20][21][22][23] without adverse side effects on treated animals. That suggests that it is safe to healthy cells.…”