Antibacterial activity of anthraquinone derivatives from Heterophyllaea pustulata (Rubiaceae)

Comini, Laura R.; Montoya, Susana C. Núñez; Páez, Paulina Laura; Argüello, Gustavo A.; Albesa, Inés; Cabrera, José Luis

doi:10.1016/j.jphotobiol.2010.09.009

Cited by 72 publications

(49 citation statements)

References 19 publications

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“…3,4 The photosensitizing properties of ( S )- 1 make it an interesting natural product with potential applications in photodynamic therapy. 5 Recently, it has been reported to be a good antibacterial agent 6 and photodynamically active toward cancer cells. 7 To date, no asymmetric syntheses of bisanthraquinones nor any synthesis of 1 have been achieved.…”

mentioning

confidence: 99%

Enantioselective Total Synthesis of (S)-Bisoranjidiol, an Axially Chiral Bisanthraquinone

Podlesny

Kozlowski

2012

Org. Lett.

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confidence: 99%

Enantioselective Total Synthesis of (S)-Bisoranjidiol, an Axially Chiral Bisanthraquinone

Podlesny

Kozlowski

2012

Org. Lett.

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“…Some Rubiaceae species have described biological properties, such as the species Uncaria tomentosa (Willd) D.C., popularly known as "unha-degato", being widely used in folk medicine for various indications: arthritis, asthma, cancer, gastric ulcer, inflammation and bleeding (Heitzman et al, 2005). Moreover, pharmacological studies also demonstrated that other species of this family have anti-inflammatory (Zhu et al, 2012), antinociceptive (Déciga-Campos et al, 2006), antibacterial (Comini et al, 2011), antitumor and antioxidant activities (Dreifuss et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

High-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis and evaluation of antioxidant and photoprotective activities of extracts from seeds of Simira gardneriana M. R. V. Barbosa and Peixoto (Rubiaceae)

Ferraz¹,

Oliveira-JÃºnior²,

Oliveira³

et al. 2017

Afr. J. Biotechnol.

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Simira gardneriana is a Rubiaceae species commonly found in the Brazilian Northeast region, presented several therapeutic and biotechnological applications. In this paper, the antioxidant and photoprotective properties of extracts from the seeds of S. gardneriana were highlighted. The antioxidant activity of ethanol and methanol extracts (Si-EtOH and Si-MeOH, respectively) was determined, using 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay. The photoprotective activity of the extracts was evaluated using a spectrophotometric method. Total phenolic and flavonoid content was determined. In addition, a qualitative analysis of phytochemical markers and a high-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis were also performed for both extracts. Concerning the antioxidant activity in vitro, Si-MeOH (EC 50 = 70.94±2.17 µg/ml) showed greater activity in comparison to Si-EtOH (EC 50 = 138.60±7.39 µg/ml). Once the sun protection factor spectrophotometric (SPF spectrophotometric ) of samples was calculated, it was demonstrated that the extracts show a similar photoprotective effect on all concentrations tested. SiEtOH and Si-MeOH tested on a concentration of 100 mg/l, exhibited SPF values equal to 3.37±0.006 and 3.36±0.007, respectively. HPLC fingerprints was recorded and showed the presence of characteristic peaks for phenolic compounds. The extracts showed significant phenols and flavonoids content according to the quantification methods used. According to the results, it was concluded that Si-EtOH and Si-MeOH have significant antioxidant and photoprotective activities. These activities are probably related to the profile of flavonoids and phenolic compounds found in this species.

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“…The first three AQs, stand out as the main components of leaves and stems and have photosensitizing properties, mediated by the generation of superoxide anion (O 2− ; Type I mechanism) and/or singlet molecular oxygen ( 1 O 2 ; Type II mechanism) [4][5][6]. AQs show important antibacterial and anticancer activity in vitro by means of the photosensitizing phenomenon [7,8]. In addition, we have previously established that extracts containing these compounds exhibit a significant antibacterial, antifungal and antiviral activity in vitro without the involvement of a photosensitizing action [4,9].…”

Section: Introduction Q4mentioning

confidence: 99%

Pressurized hot water extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae)

Vázquez

Comini

Milanesio

et al. 2015

The Journal of Supercritical Fluids

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Antibacterial activity of anthraquinone derivatives from Heterophyllaea pustulata (Rubiaceae)

Cited by 72 publications

References 19 publications

Enantioselective Total Synthesis of (S)-Bisoranjidiol, an Axially Chiral Bisanthraquinone

Enantioselective Total Synthesis of (S)-Bisoranjidiol, an Axially Chiral Bisanthraquinone

High-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis and evaluation of antioxidant and photoprotective activities of extracts from seeds of Simira gardneriana M. R. V. Barbosa and Peixoto (Rubiaceae)

Pressurized hot water extraction of anthraquinones from Heterophyllaea pustulata Hook f. (Rubiaceae)

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