Antibacterial Activity of Anthraquinone from Aloe on Spiced Pig Head

Xu, Li; Xiao, Li; Cui, Yuqian; Pang, Maolin; Wang, Fang; Qi, Jian Hua

doi:10.1088/1757-899x/275/1/012014

Cited by 7 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The core structure of both RL008 and RL009 is an anthraquinone, an aromatic organic compound. This study supports previous findings that anthraquinone compounds possess antimicrobial properties against Gram-positive bacteria, Gram-negative bacteria, and fungi ( Comini et al, 2011 ; Kemegne et al, 2017 ; Lu et al, 2011 ; Xu et al, 2017 ).…”

Section: Discussionsupporting

confidence: 92%

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus

Sirichoat

Kham-ngam

Kaewprasert

et al. 2021

PeerJ

View full text Add to dashboard Cite

Background Infection with Mycobacterium abscessus is usually chronic and is associated with clarithromycin resistance. Increasing drug resistance is a major public-health problem and has led to the search for new antimycobacterial agents. We evaluated the antimycobacterial activity, toxicity, and synergistic effects of several plant secondary metabolites against M. abscessus. Methods Twenty-three compounds were evaluated for antimycobacterial activity against thirty M. abscessus clinical isolates by broth microdilution to determine their minimum inhibitory concentration (MIC) values. Toxicity was evaluated using red and white blood cells (RBCs and WBCs). The compounds were used in combination with clarithromycin to investigate the possibility of synergistic activity. Results Five out of twenty-three compounds (RL008, RL009, RL011, RL012 and RL013) exhibited interesting antimycobacterial activity against M. abscessus, with MIC values ranging from <1 to >128 μg/mL. These extracts did not induce hemolytic effect on RBCs and displayed low toxicity against WBCs. The five least-toxic compounds were tested for synergism with clarithromycin against seven isolates with inducible clarithromycin resistance and seven with acquired clarithromycin resistance. The best synergistic results against these isolates were observed for RL008 and RL009 (8/14 isolates; 57%). Conclusions This study demonstrated antimycobacterial and synergistic activities of pure compounds extracted from medicinal plants against clarithromycin-resistant M. abscessus. This synergistic action, together with clarithromycin, may be effective for treating infections and should be further studied for the development of novel antimicrobial agents.

show abstract

Section: Discussionsupporting

confidence: 92%

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus

Sirichoat

Kham-ngam

Kaewprasert

et al. 2021

PeerJ

View full text Add to dashboard Cite

show abstract

“…The core structure of both RL008 and RL009 is an anthraquinone, an aromatic organic compound. This study supports previous findings that anthraquinone compounds possess antimicrobial properties against Gram-positive bacteria, Gram-negative bacteria, and fungi (Comini et al 2011;Kemegne et al 2017;Lu et al 2011;Xu et al 2017).…”

Section: Manuscript To Be Reviewedsupporting

confidence: 92%

Peer Review #3 of "Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus (v0.1)"

Gaviria¹

2021

View full text Add to dashboard Cite

“…Similarly, compounds isolated from Aloe sinana Reynolds were shown to have high activity against E. coli, S. typhi Typ 2, Shigella, S. aureus and V. cholerae, comparable to the reference drug, ciprofloxacin (Minale et al, 2014). The leaf latex's action was due to the secondary metabolite anthraquinones, which possess a range of functional groups and have the ability to disrupt bacterial cell wall permeability and inhibit nucleic acid synthesis and then cause death of the microorganism (Malmir et al, 2017;Xu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Background: Podoconiosis and lymphatic filariasis are the most common causes of lower limb lymphoedema in the tropics. Many sufferers experience frequent painful episodes of acute bacterial infection. Plant based traditional medicines are used to treat infections in many countries and are culturally established in Ethiopia. Ethiopian medicinal plants found to have antibacterial and antifungal activities were reviewed with the aim of increasing information about the treatment of wound infections in patients with lymphoedema.Methods: This study collates data from published articles on medicinal plants with antibacterial and antifungal activities in Ethiopia. A systematic search of Scopus, EMBASE, PUBMED/MEDLINE and Google Scholar was undertaken. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed. The protocol was registered on PROSPERO with registration number CRD42019127471. All controlled studies of in vitro antibacterial and antifungal activities were considered. All articles containing the descriptors published until June 28, 2019 were included. The outcome was measured as percent inhibition of microbial growth. For quality assessment of individual in vitro studies, OECD guidelines and the WHO-Good Laboratory Practice (GLP) handbook were used.Results: Seventy-nine studies met the inclusion criteria. A total of 150 plant species and three compounds had been tested against 42 species of bacteria, while 43 plant species had been tested against 22 species of fungus.Conclusion: Materials derived from several Ethiopian medicinal plants have been shown to have promising activity against a variety of bacteria and fungi. Those derived from Azadiractha indica A. Juss. and Lawsonia inerms L. are the most extensively studied against a wide range of gram-negative and positive bacteria, and fungal species.

show abstract

Antibacterial Activity of Anthraquinone from Aloe on Spiced Pig Head

Cited by 7 publications

References 15 publications

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus

Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus

Peer Review #3 of "Assessment of antimycobacterial activities of pure compounds extracted from Thai medicinal plants against clarithromycin-resistant Mycobacterium abscessus (v0.1)"

Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review

Contact Info

Product

Resources

About