Antibacterial Activity of Bioactive Streptomyces Species Mppo-02 Against Clinical Isolates of Burn, Dental Caries and Urinary Tract Infections

Abstract

The present study was conducted to determine antibacterial activity of ethyl acetate extract obtained from the fermentation broth of bioactive Streptomyces species MPPO-02 previously isolated from a rhizosphere soil of Mahishi, Karnataka, India. Agar well diffusion assay was performed to investigate inhibitory effect of ethyl acetate extract against a total of 15 clinical isolates from burn, dental caries and urinary tract infection. The extract was found inhibitory against all test bacteria but to a varied extent. Gram positive bacteria were found more susceptible to extract when compared to Gram negative bacteria. The isolate MPPO-02 can be exploited for the development of agents active against pathogenic microorganisms. Further studies on purification of active principles from solvent extract, their characterization and inhibitory activity are to be carried out.