Antibacterial activity of Brazilian red propolis and in vitro evaluation of free radical production

Neto, Nilson Ferreira de Oliveira; Bonvicini, Jéssica Fernanda Sena; Souza, Gabriela Leite de; Santiago, Mariana Brentini; Veneziani, Rodrigo Cássio Sola; Ambrósio, Sérgio Ricardo; Bastos, Jairo Kenupp; Silva, Marcelo José Barbosa; Martins, Carlos Henrique Gomes; Moura, Camilla Christian Gomes; Turrioni, Ana Paula Silveira

doi:10.1016/j.archoralbio.2022.105520

Cited by 7 publications

(2 citation statements)

References 49 publications

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“…These substances must have a potent antimicrobial action to combat the microbiota present in endodontic infections [1,3,5]. The antimicrobial action of propolis in relation to the oral microbiota has been demonstrated over the years [13,17,21,28,34]. Until the late 1990s and early 2000s, formocresol and its like were often used as intracanal drugs, but such chemicals used as bactericides have been shown to diffuse throughout the body from the root apex, resulting in cases of undesirable effects, including allergies.…”

Section: Discussionmentioning

confidence: 99%

Potential Use of Propolis as Endodontic Irrigant

Carvalho,

De Lima,

Santos Moraes

et al. 2023

DOHC

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Objective of this work was to review the use of propolis as an endodontic irrigant. For this, keywords were searched in the PubMed database, from April to October 2022. There are many chemical compounds in propolis from different geographic regions; Flavonoids are one of the most important agents that have anti-inflammatory, anti-viral, anti-allergic, anti-cancer, anti-bacterial and antioxidant effects. According to the mentioned properties, propolis can be used as a canal irrigation solution, as well as intracanal medicine in endodontic treatments. The results described in the literature are practically unanimous in showing the antibacterial and antifungal effects of different propolis extracts at different concentrations. In addition to flavonoids, other components of propolis such as resin, pollen, vitamins and phenols, indicate that propolis can be used not only as an intracanal irrigation solution, but for various purposes, with a promising role in endodontics as well as dentistry.

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Section: Discussionmentioning

confidence: 99%

Potential Use of Propolis as Endodontic Irrigant

Carvalho,

De Lima,

Santos Moraes

et al. 2023

DOHC

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“…More recently, the Brazilian red propolis was tested against P. melaninogenica, Actinomyces viscosus, Prevotella nigrescens, P. endodontalis , V. parvula , P. gingivalis , P. intermedia , P. micra and F. nucleatum , in which the red propolis was effective against these pathogens involved in primary endodontic infections, the study indicated the use of the red propolis as endodontic irrigant or intracanal medication in a concentration ranging from 6.25 to 200 mg/mL [ 34 ]. Differently, in the present study, lower concentrations of the BGP-AqExt were effective against the same pathogens.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Effect of Brazilian Green Propolis Aqueous Extract against Dental Anaerobic Bacteria

et al. 2022

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Green propolis may represent a promising therapeutic alternative against dental anaerobic pathogens because of its antimicrobial action. This study aimed to evaluate the antimicrobial and antibiofilm actions of Brazilian green propolis aqueous extract (BGP-AqExt) against dental anaerobic bacteria. The minimum inhibitory concentration (MIC) and minimum microbicide concentration (MMC) of the extract were determined against the standard strains (ATCC) of Fusobacterium nucleatum, Parvimonas micra, Prevotella intermedia, Porphyromonas gingivalis and Porphyromonas endodontalis. BGP-AqExt was chemically characterized by high-performance liquid chromatography with diode-array detection (HPLC-DAD) analysis. Antibiofilm action was measured by MTT and crystal violet tests. The data were statistically analyzed by ANOVA and Tukey (5%) tests. The extract had antimicrobial action against all tested anaerobic bacteria, with an MIC value of 55 mg/mL for all bacteria, an MMC of 27.5 mg/mL for F. nucleatum and P. micra and 55 mg/mL for P. intermedia. Chemically, BGP-AqExt is composed of quercetin, gallic acid, caffeic and p-coumaric acid, drupani, kaempferol and Artepillin C. Significant reductions in biomass and metabolic action of biofilms were found after BGP-AqExt application. Therefore, BGP-AqExt has an antimicrobial and antibiofilm effect against dental anaerobic bacteria.

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Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

Leveque,

Guittat,

Thivichon‐Prince

et al. 2023

Int Endodontic J

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BackgroundThe clinical results following regenerative endodontic procedures (REPs) vary according to numerous parameters, including the presence of bacteria. This limitation reduces the indications for REPs and calls for the development of next generation antibacterial strategies (NGAS) providing alternatives to current antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP) and (Ca(OH)2).ObjectivesThe present scoping review aims to describe the current trends regarding the use of such strategies and highlight future perspectives.MethodsFour databases (PUBMed, Cochrane, ClinicalTrials and Science Direct) were searched until 1st May 2023.ResultsA total of 918 records were identified, 133 were screened and assessed for eligibility, and 87 articles were included. The findings show that (1) clinical studies are only available for CAS, (2) although next generation strategies are the most studied approach since 2017, they are all at the pre‐clinical stage, (3) most of the next generation strategies use galenic forms which offer cell support and colonization and which simultaneously contain antibacterial molecules as alternatives to CAS and to antibiotics in general, (4) standardization is required for future research, specifically regarding the bacterial strains studied, the use of biofilm studies and the cellular behaviour assessments.ConclusionAlthough NGAS are promising strategies to improve REPs in the context of infection, the current evidence is mostly limited to pre‐clinical studies. Further methodological improvement is required to allow relevant comparisons between studies and to reduce the time from bench to bedside.

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Antibacterial activity of Brazilian red propolis and in vitro evaluation of free radical production

Cited by 7 publications

References 49 publications

Potential Use of Propolis as Endodontic Irrigant

Potential Use of Propolis as Endodontic Irrigant

Antimicrobial and Antibiofilm Effect of Brazilian Green Propolis Aqueous Extract against Dental Anaerobic Bacteria

Next generation antibacterial strategies for regenerative endodontic procedures: A scoping review

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