Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions

Recent advances of chitosan nanoparticles as drug carriers

“…12 As ionic cross-linking can be performed at room temperature to avoid the use of organic solvent, and uniform nanoparticles with an adjustable size can be obtained easily, cross-linking has been widely used in encapsulation of protein and gene drugs. Using ionic cross-linking, chitosan nanoparticles were prepared by Du et al 13 …”

Control of mycotoxigenic fungi with microcapsules of essential oils encapsulated in chitosan

“…It is reported that the zeta potential or surface charge is an essential parameter in the characteristics of a particle, mainly through its influence on stability (Du et al, 2009) and determines the antimicrobial potential on fungi and bacteria (Cai et al, 2008). The zeta potential (mV) of the chitosan microparticles with tripolyphosphate and essential oils incorporated were +38.5 ± 0.9, +38.5 ± 2.1, +29.6 ± 0.2 with size (nm) of 775.2 ± 291.6, 788.0 ± 96.8, and 735.8 ± 118.8 for thyme, clove and cinnamon, respectively.…”

“…Some studies reported a higher amount of TPP and high inhibition of microorganism growth. Zhao et al (2015) in their study to elaborate chitosan nanoparticles, added TPP (0.25%), Du et al (2009) (2015) TPP (0.3%). The IC 50 of thyme, clove, and cinnamon EDs for A. parasiticus was 117.9, 111.8, and 156.1 ppm, respectively, whereas for F. verticillioides it was 67.7, 154.6, and 156.1 ppm, respectively.…”

“…Additionally, they suggested that chitosan has fungistatic activity in A. niger, which could have happened in our study with F. verticillioides and A. parasiticus. This effect could be attributed to the chitosan chelating potential to calcium (Ca 2+ ), which is conferred by the free amino groups and hydroxyls present, or to the electrostatic interaction between the protonated amino groups (NH 3 + ) with components of the cellular membrane of the fungus such as phospholipids (Ali et al, 2010;Du et al, 2009). Table 4 shows the results of aflatoxin and fumonisin production in corn grain with microcapsules of chitosan with essential oils encapsulated.…”

Effect of Laboratory Synthesized Cu-Chitosan Nanocomposites on Control of PFSR Disease of Maize caused by Fusarium verticillioids

“…With the high surface area of nanochitosan, more and more interaction of nanoparticles could be happened on external and internal surfaces of fungi and bacteria which lead to inhibition of various metabolic reactions. On the other hand, chitosan in nanoform also act strong binder of metals in the cell wall of fungi and bacteria (Qi et al, 2004;Du et al, 2009;Saharan et al, 2013;Saharan et al, 2015).…”