Antibacterial activity of cobalt(II) complexes with some benzimidazole derivatives

Abstract

The antibacterial activities of cobalt(II) complexes with two series of benzimidazoles were evaluated in vitro against three Gram-positive bacterial strains (Bacillus cereus, Staphylococcus aureus, and Sarcina lutea) and one Gram-negative isolate (Pseudomonas aeruginosa). The minimum inhibitory concentration was determined for all the complexes. The majority of the investtigated complexes displayed in vitro inhibitory activity against very persistent bacteria. They were found to be more active against Gram-positive than Gram-negative bacteria. It may be concluded that the antibacterial activity of the compounds is related to the cell wall structure of the tested bacteria. Comparing the inhibitory activities of the tested complexes, it was found that the 1-substituted--2-aminobenzimidazole derivatives were more active than complexes of 1-substituted-2-amino-5,6-dimethylbenzimidazoles. The effect of chemical structure on the antibacterial activity is discussed.

The effect of lipophilicity on the antibacterial activity of some 1-benzylbenzimidazole derivatives

“…The synthesis of benzimidazoles has received a lot of attention owing to the varied biological activity exhibited by a number of these compounds. [1][2][3][4][5][6][7] This class of molecules proved to be very important, as they possess pharmaceutical properties, including antibacterial, against different strains of Gram-positive and Gram-negative bacteria, 8-10 antifungal 3 and herbicidal 11 activity. It is also well-known that these molecules are present in a variety of analgesic, 12 anti-oxidant, 13,14 anti-allergic 15,16 and antitumoral 17 agents.…”

Synthesis, spectroscopic, thermal analyses, and anti-cancer studies of metalloantibiotic complexes of Ca(II), Zn(II), Pt(II), Pd(II), and Au(III) with albendazole drug

“…Albendazole therapy is very important in treating systemic cestode infections especially in inoperable or disseminated cases of hydatidosis [12] and neurocysticercosis [13]. Benzimidazole is essential structural block of organic compounds used as DOI: 10.1134/S1070363215070270 antimicrobial agents against most microorganisms [14][15][16][17][18][19]. It is important in synthesis of anti-fungal [20], anti-tubercular [21], anti-oxidant [22], anti-allergic [23], antiparasitic [24] and herbicidal [25], anthelmintic [26], nematodes, hidatidosis, and teniasis [27] agents and many other biologically active compounds [28][29][30].…”

QSAR modeling of antibacterial activity of some benzimidazole derivatives

“…The position and type of the substituents on the benzimidazole ring are responsible for the variety of biological activities. Many derivatives of benzimidazole are well known as antibacterial agents, as well as this class of compounds have been found to show antimicrobial activities against Gram-positive and Gramnegative bacteria, primarily because of the potential bio-activity of benzimidazole-based ligands [8][9][10][11][12][13][14][15][16][17][18][19]. So, the incorporation of the imidazole and benzimidazole nuclei is an important synthetic strategy in drug discovery.…”

“…In view of the above and in continuation of our studies on inhibitory activities of benzimidazole derivatives [4][5][6][7], [11][12][13][14][15][16][17][18], as well as on correlation of molecular properties with activity, the objective of this investigation was to study the usefulness of QSAR in the prediction of the antibacterial activity of benzimidazole derivatives against Gram-negative bacteria Pseudomonas aeruginosa. The multiple linear regression (MLR) models have been developed as mathematical equations which relate chemical structure to the inhibitory activity.…”