Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification

Abstract

In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH 2 and COOMe for M = Cu and X = COOH and OMe for M = Co]. The activity study of the assynthesized metalloporphyrins toward two Gram-positive (S. aureus and S. pyogenes) and two Gram-negative (E. coli and K. pneumoniae) bacteria showed a promising inhibitory activity. Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5 mm against Staphylococcus aureus (S. aureus). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position.

Gallium Complex-Functionalized P4HB Fibers: A Trojan Horse to Fight Bacterial Infection

“…The antibacterial efficacy and required GaPPIX concentration will strongly depend on the particular wound infection scenario, and underlying effects need to be further investigated and considered for future medical application of GaPPIX-functionalized materials. Nevertheless, GaPPIX is a promising alternative to current antibiotics and will, without a doubt, be investigated in future studies along with other metal complexes. , Interestingly, Beyene and Wassie investigated the antibacterial effect of copper (Cu) or cobalt (Co) that was complexed within porphyrin rings containing different substitutes than the protoporphyrin ring . It was shown that porphyrin rings bearing carboxylic acid groups had increased antibacterial efficacy compared to other substitutes.…”

“…44,47 Interestingly, Beyene and Wassie investigated the antibacterial effect of copper (Cu) or cobalt (Co) that was complexed within porphyrin rings containing different substitutes than the protoporphyrin ring. 48 It was shown that porphyrin rings bearing carboxylic acid groups had increased antibacterial efficacy compared to other substitutes. The authors concluded that this might be due to an enhanced lipophilicity of the compound and thus enhanced uptake through the bacterial membranes.…”

Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo

“…As an essential trace element in the human body, Cu can promote bone regeneration and antibacterial activity [ [16] , [17] , [18] ]; thus, it is an ideal material for prosthesis modification. However, a large release of Cu ions can cause tissue damage [ 19 ].…”

Synthesis of New Cobalt(III) Meso-Porphyrin Complex, Photochemical, X-ray Diffraction, and Electrical Properties for Photovoltaic Cells

“…Cobalt metalloporphyrin complexes have been extensively investigated since the early sixties, firstly as biomimetic models of hemoproteins, especially of vitamin B 12 [1][2][3]. These coordination compounds are indeed explored in many domains, such as catalysts [4], gas detection [5], biological activities, antifungal and antibacterial [6,7], building blocks [8,9], photovoltaic cells [10][11][12], and sensors [13,14]. Organic dyes are used in many industrial applications: paper, cosmetics, but especially in the food, textile, pharmaceutical, and medical diagnostic industries [15,16].…”