Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold

Kosikowska, Urszula; Wujec, Monika; Trotsko, Nazar; Płonka, W; Paneth, Piotr; Paneth, Agata

doi:10.3390/molecules26010170

Cited by 27 publications

(15 citation statements)

References 62 publications

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“…Moreover, the lack of the antibacterial activity against P. aeruginosa and P. gingivalis demonstrate that our system is highly selective in killing different strains of bacteria, and this can be considered an important advantage. Concerning the molecular mechanism of the antibacterial activity of these types of compounds, it is still under debate in the literature, but it seems that the inhibitory action towards bacterial topoisomerases could be the main explanation [ 37 , 38 ]. Undoubtedly, more in-depth research in this area is urgently needed in order to establish the exact mechanism of action of these compounds.…”

Section: Resultsmentioning

confidence: 99%

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

et al. 2022

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Bacterial oral diseases are chronic, and, therefore, require appropriate treatment, which involves various forms of administration and dosing of the drug. However, multimicrobial resistance is an increasing issue, which affects the global health system. In the present study, a commercial amphiphilic copolymer, Pluronic F127, was used for the encapsulation of 1-(5′-nitrobenzimidazole-2′-yl-sulphonyl-acetyl)-4-aryl-thiosemicarbazide, which is an original active pharmaceutical ingredient (API) previously synthesized and characterized by our group, at different copolymer/API weight ratios. The obtained micellar systems, with sizes around 20 nm, were stable during 30 days of storage at 4 °C, without a major increase of the Z-average sizes. As expected, the drug encapsulation and loading efficiencies varied with the copolymer/API ratio, the highest values of 84.8 and 11.1%, respectively being determined for the F127/API = 10/1 ratio. Moreover, in vitro biological tests have demonstrated that the obtained polymeric micelles (PMs) are both hemocompatible and cytocompatible. Furthermore, enhanced inhibition zones of 36 and 20 mm were observed for the sample F127/API = 2/1 against S. aureus and E. coli, respectively. Based on these encouraging results, it can be admitted that these micellar systems can be an efficient alternative for the treatment of bacterial oral diseases, being suitable either by injection or by a topical administration.

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Section: Resultsmentioning

confidence: 99%

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

et al. 2022

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“…Kosikowska and coworkers reported fluorinated 1,2,4-triazole analogs scaffold 126–131 ( Supplementary Table S1 ) ( Kosikowska et al, 2020 ). In vitro antibacterial activity was performed using six reference Gram-positive strains, eight MSSA clinical isolates, and eight MRSA clinical isolates.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

et al. 2022

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Fluorinated heterocycles have attracted extensive attention not only in organic synthesis but also in pharmaceutical and medicinal sciences due to their enhanced biological activities than their non-fluorinated counterparts. Triazole is a simple five-membered heterocycle with three nitrogen atoms found in both natural and synthetic molecules that impart a broad spectrum of biological properties including but not limited to anticancer, antiproliferative, inhibitory, antiviral, antibacterial, antifungal, antiallergic, and antioxidant properties. In addition, incorporation of fluorine into triazole and its derivatives has been reported to enhance their pharmacological activity, making them promising drug candidates. This mini-review explores the current developments of backbone-fluorinated triazoles and functionalized fluorinated triazoles with established biological activities and pharmacological properties.

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“…However, there is still a requirement for application in industrial expert and a widely approach to the integration of zinc nanoparticles. Numerous techniques applied, for example, the combination of zinc nanoparticles, the reaction of substances and the reaction of compounds changing micelles, the extensively used of zinc oxide in radiation [ 9 , 10 , 11 , 12 ], the electrochemical, sonochemical, microwave [ 13 , 14 , 15 ] and green science applications [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology, Green Synthesis and Biological Activity Application of Zinc Oxide Nanoparticles Incorporated Argemone Mxicana Leaf Extract

Chinnapaiyan¹,

Selvam²,

Bassyouni³

et al. 2022

Molecules

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Nanomaterial is a rapidly growing area that is used to create a variety of new materials and nanotechnology applications from medical, pharmaceuticals, chemical, mechanical, electronics and several environmental industries including physical, chemical and biological nanoparticles are very important in our daily life. Nanoparticles with leaf extract from the healthy plant are important in the area of research using biosynthesis methods. Because of it’s used as an environmentally ecofriendly, other than traditional physical and chemical strategies. In particular, biologically synthesized nanoparticles have become a key branch of nanotechnology. The present work presents a synthesis of zinc oxide nanoparticles using an extract from the Argemone leaf Mexicana. Biosynthetic nanoparticles are characterized by X-ray diffraction (XRD), Ultraviolet visible (UV-vis) spectroscopy analysis, a Fourier Transform Infrared Spectroscopy analysis (FTIR) and a scanning electron microcopy (SEM), X-ray analysis with dispersive energy (EDAX). XRD is used to examine the crystalline size of zinc oxide nanoparticles. The FTIR test consists in providing evidence of the presence of targeted teams. UV is used for optical properties and calculates the energy of the bandwidth slot. The scanning microscope emission reveals the morphology of the surface and the energy dispersive X-ray analysis confirms the basic composition of zinc oxide nanoparticles. It is found that zinc nanoparticles are capable of achieving high anti-fungal efficacy and therefore have a high potential antimicrobial activity of ZnO NPs, like antibacterial and high antioxidant. Zinc Oxide nanoparticles from the Argemone Mexicana leaf extract have several antimicrobial applications, such as medical specialty, cosmetics, food, biotechnology, nano medicine and drug delivery system. ZnO nanoparticles are important because they provide many practical applications in industry. The most important use of nanoparticles of ZnO would be strong antibacterial and antioxidant activity with a simple and efficient biosynthesis method may be used for future work applications.

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Antibacterial Activity of Fluorobenzoylthiosemicarbazides and Their Cyclic Analogues with 1,2,4-Triazole Scaffold

Cited by 27 publications

References 62 publications

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

Nanotechnology, Green Synthesis and Biological Activity Application of Zinc Oxide Nanoparticles Incorporated Argemone Mxicana Leaf Extract

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