Antibacterial activity of graphene-based materials

Szunerits, Sabine; Boukherroub, Rabah

doi:10.1039/c6tb01647b

Cited by 275 publications

(147 citation statements)

References 178 publications

(190 reference statements)

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“…Graphene, composed of a single layer of carbon atoms arranged in a hexagonal lattice, is the superstar of the 2D material family, and GMs are the most explored 2D materials for antimicrobial applications . Their sharp edges, enormous basal planes, and surface moieties endow GMs with intrinsic antimicrobial activity mainly through physical interactions with microorganisms and/or by inducing oxidative stress.…”

Section: Antimicrobial Activity Of Gmsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

123

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Since the "birth" of graphene in 2004, two-dimensional (2D) materials have attracted unprecedented research interest from scientists and have stimulated numerous applications in various fields, such as electronic/optical devices, energy storage, catalysis, sensors, and biomedicine. In this review, we summarize recent advances in the antimicrobial applications of 2D materials, such as graphene materials (GMs), layered double hydroxides (LDHs), transition-metal dichalcogenides (TMDs), graphitic carbon nitride (g-C N ), MXenes, black phosphorus (BP), and their derivatives. This review also correlates the unique physicochemical properties of 2D materials with their antimicrobial activities. Finally, some current challenges and future perspectives in this field are also presented.

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Section: Antimicrobial Activity Of Gmsmentioning

confidence: 99%

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Sun

2018

Chemistry An Asian Journal

123

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“…[21][22][23] For instance, graphene (and graphene oxide) has been systematically studied 24 for its antimicrobial activities, [25][26][27][28] along with its underlying molecular mechanisms. [29][30][31][32] It was revealed that graphene and graphene oxide nanosheets can cut into cell membranes, 32 extract large amount of phospholipids, 32 and create holes (pores) on cell membranes, 33 through large scale molecular dynamics simulations.…”

mentioning

confidence: 99%

Membrane destruction-mediated antibacterial activity of tungsten disulfide (WS₂)

et al. 2017

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The antibacterial activities of tungsten disulfide (WS 2 ) nanosheets against two representative bacterial strains: Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus)were evaluated by colony-forming unit (CFU) studies. The WS 2 samples demonstrate a time and concentration dependent antibacterial activity (retardation of bacterial growth) for both bacterial strains.Morphology analyses reveal that WS 2 nanosheets adhere to the bacterial surfaces, resulting in robust inhibition of cell proliferation once a bacterium is fully covered with this nanomaterial. More importantly, the intimate contact of WS 2 nanosheets with a bacterium cell membrane can cause serious damage to the membrane integrity, and subsequently the cell death. On the other hand, the reactive oxygen species (ROS) generated by WS 2 nanosheets are found to be modest regardless of the WS 2 concentration, which is contradictory to the case of its structural analogue, MoS 2 , where ROS also play a significant role in its antibacterial activity. Taken together, our findings provide a detailed understanding of the antibacterial mechanism of WS 2 nanosheets, which might help promote their potential applications in biomedical fields.

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“…First, AgNPs may accumulate in the tissues, and Ag ions (Ag + ) may cause local or systemic side effects at high dosages or prolonged use, including allergic reactions, skin staining, and cellular toxicity. [16][17][18] Therefore, although it is not confirmed by experimental evidence to our knowledge, the manifestation of nanocarbon's antimicrobial activity in a multimodal manner might give them an edge in escaping from or delaying the development of microbial resistance. [14,15] Antimicrobial nanocarbons such as single-walled carbon nanotubes (SWCNTs), multiwalled carbon nanotubes (MWCNTs), and graphene materials (GMs), on the contrary, seemingly function through the damaging of cellular envelopes via the combinational effect of multiple "physicochemical" routes.…”

Section: Introductionmentioning

confidence: 86%

“…For instance, depending on the degree of oxidation, the C/O ratio of the products from the Hummers method might typically be as low as ≈2-4, which correspond to 20-35% of O. [17,143,157] Nanodots and Nanodiamonds [49,51] Besides, not only the overall C/O ratios but also the abundance profiles of O-containing functional groups, such as carboxyl, carbonyl, hydroxyl, and epoxy groups, change as a result of the production and post-synthesis treatments.…”

Section: Structure-property Relationshipsmentioning

confidence: 99%

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

Karahan

Wiraja

et al. 2018

Adv Healthcare Materials

183

142

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Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad-spectrum antimicrobial agents. This report describes their state-of-the-art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure-property-activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection-protective coatings, and antibiotic-like formulations ("nanoantibiotics") is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine.

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Antibacterial activity of graphene-based materials

Abstract: Current efforts in the formulation of graphene-based nanocomposites with antimicrobial and antibiofilm activities in fighting against bacterial targets are reviewed.

Cited by 275 publications

References 178 publications

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Membrane destruction-mediated antibacterial activity of tungsten disulfide (WS₂)

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

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Antibacterial activity of graphene-based materials

Abstract: Current efforts in the formulation of graphene-based nanocomposites with antimicrobial and antibiofilm activities in fighting against bacterial targets are reviewed.

Cited by 275 publications

References 178 publications

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Two‐Dimensional Materials for Antimicrobial Applications: Graphene Materials and Beyond

Membrane destruction-mediated antibacterial activity of tungsten disulfide (WS2)

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives

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Product

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Membrane destruction-mediated antibacterial activity of tungsten disulfide (WS₂)