Antibacterial Activity of Hybrid Polymeric Scaffold for Reconstruction of Tubular Bone Defects

Ultra-High Molecular Weight Polyethylene/Titanium-Hybrid Implant for Bone-Defect Replacement

“…However, these differences were in the range of the bone properties' statistical scatter, which depended on bone composition, porosity, age, gender, and functional demands. The solid UHMWPE covering the UHMWPE/titanium-hybrid implant could be saturated with an antibiotic (e.g., amoxicillin) using supercritical-fluid-impregnation technologies, as illustrated in our previous article [36]. Adding an antibiotic to the solid UHMWPE could solve the problem of peri-implant inflammation that is often induced by opportunistic microflora.…”

“…The solid UHMWPE covering the UHMWPE/titanium-hybrid implant could be saturated with an antibiotic (e.g., amoxicillin) using supercritical-fluid-impregnation technologies, as illustrated in our previous article [ 36 ]. Adding an antibiotic to the solid UHMWPE could solve the problem of peri-implant inflammation that is often induced by opportunistic microflora.…”

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

“…Several antimicrobial scaffold delivery systems have been developed in this research line as an emerging technology for the reconstruction of bone and cartilage tissue defects [ 269 ]. A reinforced hybrid scaffold consisting of continuous and porous layers of titanium and ultrahigh-molecular-weight polyethylene (UHMWPE), a polymer with good compatibility, and a subsequent amoxycillin impregnation were prepared to prevent the appearance of opportunistic infections [ 219 ]. As a result, the contact of Gram-positive and Gram-negative bacterial cultures ( S. aureus , S. epidermidis and E. coli) with the hybrid polymeric scaffolds suppressed microorganism growth and colony formation.…”

“…Other studies also reported in vivo assessment of biocompatibility in rat [ 194 ] or rabbit [ 168 , 203 ] models. Finally, in scaffolds developed with combined or alternative strategies, biocompatibility was analyzed in MC3T3-E1 preosteoblasts [ 216 , 223 ], osteoblasts [ 208 , 212 , 221 ] and osteoblast-like cells [ 210 , 213 , 214 , 217 , 220 , 223 , 225 ], MSCs [ 176 , 207 , 209 , 211 , 215 , 224 ], although it was not assessed in other studies [ 206 , 219 , 226 ]. In vivo assays performed on rat [ 208 ] and rabbit models [ 209 ] were also reported.…”