Antibacterial activity of Curcuma longa L. against methicillin‐resistant Staphylococcus aureus

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important hospital and community pathogens. Therefore, new agents are needed to treat MRSA associated infections. The present study investigated the antimicrobial activity of ethyl acetate, methanol and water extracts of Curcuma longa L. (C. longa) against MRSA. The ethyl acetate extract of C. longa demonstrated a higher antibacterial activity than the methanol extract or water extract. Since the ethyl acetate extract was more active than the other extracts, the study examined whether the ethyl acetate extract could restore the antibacterial activity of beta-lactams and alter the MRSA invasion of human mucosal fibroblasts (HMFs). In the checkerboard test, the ethyl acetate extract of C. longa markedly lowered the MICs of ampicillin and oxacillin against MRSA. In the bacterial invasion assay, MRSA intracellular invasion was significantly decreased in the presence of 0.125-2 mg/mL of C. longa extract compared with the control group. These results suggest that the ethyl acetate extract of C. longa may have antibacterial activity and the potential to restore the effectiveness of beta-lactams against MRSA, and inhibit the MRSA invasion of HMFs.

Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries

“…Antimicrobial resistance is resulting in increased morbidity, mortality and health-care costs. The discovery and development of potent and nontoxic, antimicrobial agents has thus become an important scientific challenge (Natarajan et al, 2003;Weigel et al, 2003;Kim et al, 2005). Plants synthesize chemicals as part of their defense against pathogens.…”

Antibacterial activity of selected Dendrobium species against clinically isolated multiple drug resistant bacteria

“…In the present study, analyses of growth inhibition activity performed by using the well diffusion method showed that all the tested plants, which are commonly used by traditional medical practitioners, exhibited moderate activity against clinical isolates of bacterial strains at extract concentrations of 1 mg/ml Nitta et al, 2002;Voravuthikunchai and Kitpipit, 2005). Infections caused by multiple drug resistance, including resistance to β-lactam, are among the most difficult infections to treat (Abu-Shanab et al, 2004, 2006Kim et al, 2005). In this study, the growth of S. aureus, E. coli, K. pneumoniae, S. typhi and A. baumannii were markedly inhibited by some extracts of D.…”

“…Multiple drug resistant (MDR) pathogens has been increasing, causing nosocomial and communityacquired deadly infections mainly due to the extensive utilization of antibiotics (Köck et al, 2010;Mongalo et al, 2013). Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and Acinetobacter baumannii have inherent resistant to most available antibiotics (Chambers, 1997;Kim et al, 2005;Patzer and Dzierzanowska, 2007).…”

Continentalic acid from Aralia continentalis shows activity against methicillin‐resistant Staphylococcus aureus

“…Therefore, new agents are needed to treat MRSA associated infection. To meet this need, plant extracts have been screened for activity against strains of MRSA (Hur et al, 2004;Kim et al, 2004Kim et al, , 2005.…”