Antibacterial Activity of Lactic Acid Bacteria against Helicobacter pylori Evidence by in vivo and in vitro Studies

Nasr, Nesreen M.; Khider, Manal; Metry, Wedad A.; Atallah, K.

doi:10.20546/ijcmas.2017.612.488

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…In vivo studies demonstrated that previous colonization with probiotics prevents or reduces H. pylori infection in experimental animals [ 27 ]. Consequently, regardless of the mechanisms of inhibition of the H. pylori adherence to epithelial cells, probiotics could prevent H. pylori colonization by inhibiting bacterial adhesion to gastric epithelial cells [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…Bacterial suspensions adjusted to McFarland turbidity standard 0.5 (1.5 × 10 −8 CFU/mL) were inoculated on plates containing Muller-Hinton agar with 5% of horse blood. Filter paper discs (6 mm diameter) impregnated with 60 µL of different concentrations of each plant extract (10,20,30,40,50,60,70,80,90,100,150,250, 500 and 1000 µg/mL) were placed on the inoculated agar surfaces. Methanol at a concentration of 80% (60 µL) was used as a negative control.…”

Section: Evaluation Of Anti-h Pylori Effect Of Plant Extracts Evaluat...mentioning

confidence: 99%

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In Vitro and In Vivo Study of Combined Effect of Some Algerian Medicinal Plants and Probiotics against Helicobacter pylori

Hasna,

Houari,

Koula

et al. 2023

Microorganisms

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Helicobacter pylori causes gastritis, peptic ulcers and gastric cancer and affects more than half of the world’s population. Although this infection can have serious consequences, no novel cure or remedy have been discovered, the present therapy still relies on a variety of known antibiotics and anti-secretory agents. In the present study, the potential effect of combinations between methanolic extracts of four Algerian medicinal plants, garlic (Allium sativum), red onion (Allium cepa), cumin (Cuminum cyminum L.) and fenugreek (T. foenum-graecum L.), with different strains of lactic acid bacteria against H. pylori, was investigated. Similarly, the in vivo antibacterial effect of fenugreek extract combined with Bifidobacterium breve on H. pylori colonization potential to confirm the enhanced effect of the mixture was explored. Helicobacter pylori was inhibited by all combined mixtures of extracts and probiotics with varying results. The highest anti-H. pylori activities were found in fenugreek/B. breve, cumin/B. breve, garlic/B. breve and onion/B. breve combinations with inhibition diameters of 29, 26, 23 and 25 mm, respectively. Preliminary studies on the effect of probiotics against H. pylori revealed that the inhibition was due to lactic acid and bacteriocins and it was also related to the presence of phenolic compounds in the studied plants, such as gallic acid, caffeic acid, quercetin and vanillic acid. Fenugreek extract was found to inhibit the growth of H. pylori in a concentration-dependent manner. When H. pylori-infected rats were administered B. breve, the infection rate of H. pylori was significantly reduced, while the combination of B. breve and fenugreek extract effectively inhibited H. pylori. In addition, the B. breve and fenugreek extract mixture significantly reduced gastritis in H. pylori-infected rats. These results suggest that this complex mixture may be an alternative to treating diseases caused by H. pylori infection.

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Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Anti-h Pylori Effect Of Plant Extracts Evaluat...mentioning

confidence: 99%

In Vitro and In Vivo Study of Combined Effect of Some Algerian Medicinal Plants and Probiotics against Helicobacter pylori

Hasna,

Houari,

Koula

et al. 2023

Microorganisms

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“…The rats were held in reserve in the animal house of the Salahaddin University-College Erbil's of Education for a week and provided a basic meal. In this study, the rats were fasted in the morning and afternoon first inoculated with plant extracts then immediately inoculated with 1ml H. pylori suspension (5×10 8 -5×10 10 CFU/ml) by gavage twice daily at an interval of 4h for three consecutive days, then left on normal feeding for 15 days to see the effect of the plants extracts with H. pylori activity (15), before inoculating animals with plants extract and H. pylori the animals do the antigen test via stool to ensure that did not infect with H. pylori before, In last period of prevention, anesthetized of the rats done by intramuscular injection of mixed xylazine-ketamine (1:9) as a single dose in the same syringe, then the Stomach was removed of each rat from each group, then dissects the stomach.…”

Section: Induction Of Gastric Ulcer By H Pylorimentioning

confidence: 99%

Gastro-protective and therapeutic effect of Punica granatum against stomach ulcer caused by Helicobacter Pylori

Muhialdin¹,

Alamri²,

Hussein³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…Omeprazole is used to control heartburn, acute gastritis, duodenitis, esophagitis attributable to recurrence of gastrointestinal material, peptic ulcer, and other secretary diseases. [8]…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hypericum perforatum Extract on Gastric Ulcer Development in Rat Models

Hussein

2023

Cihan U Erbil SCI J

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Gastric ulcer is a serious condition that results from the wearing/tearing of the stomach mucosa. A physiological equilibrium is maintained between mucosal defense and aggressive factors. In this study, the effectiveness of medicinal plants (Hypericum perforatum) in the management of gastric ulcer was compared to that of omeprazole, a well-known drug for gastric ulcer. This study involved numerous study groups of male rats comprising of the following: the first group (control group exposed to H. pylori and fed with normal animal feed), the second group (rats exposed to H. pylori and treated with two doses {of 250 mg/kg and 500 mg/kg} of aqueous H. perforatum), and the third group (rats exposed to H. pylori and treated with 20 mg/kg of omeprazole). The outcome of the study demonstrated that a high dose of H. perforatum prevents (50.65%) the development of stomach ulcers. The group treated with omeprazole revealed a formation of stomach ulcers (24.50%). A high dose of the aqueous plant extracts showed greater effectiveness in preventing gastric ulcer formation compared to the lower dosage.

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Antibacterial Activity of Lactic Acid Bacteria against Helicobacter pylori Evidence by in vivo and in vitro Studies

Cited by 3 publications

References 39 publications

In Vitro and In Vivo Study of Combined Effect of Some Algerian Medicinal Plants and Probiotics against Helicobacter pylori

In Vitro and In Vivo Study of Combined Effect of Some Algerian Medicinal Plants and Probiotics against Helicobacter pylori

Gastro-protective and therapeutic effect of Punica granatum against stomach ulcer caused by Helicobacter Pylori

The Effect of Hypericum perforatum Extract on Gastric Ulcer Development in Rat Models

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