Since ancient times, medicinal plants have played a key role in the management of some health problems and in the discovery of new drugs. For many years, Dacryodes edulis (G. Don) is reported to be used by local populations of West and Central Africa for its nutritional values and by traditional medicine practitioners for the treatment of many diseases among which: leprosy, dysentery, anaemia, spitting blood, debility, stiffness, tonsillitis, skin diseases (such as scabies, ringworm, rash and wound), worms, ear infections, fever, headache, malaria, cephalgia, treatment of snakebite, jiggers, protection of the skin, oral hygiene and cicatrization of wounds. Many parts of this tree have been scientifically studied for their numerous therapeutic activities such as: antioxidant, antimicrobial and antibacterial, antimalarrial, Haemopoietic, Cardiovascular and Anti-drepanocytary. Moreover, its spiritual and economic values are of great import for the local populations. No part of this plant has been mentioned to be toxic. This review study is an attempt to give a detailed survey of the literature on its traditional uses, phytoconstituents, pharmacological activities, spiritual and economic values, as well as it toxicity.