Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp

Cruz-Sánchez, Natividad Giovana De La; Gómez-Rivera, Abraham; Álvarez-Fitz, Patricia; Ventura-Zapata, Elsa; Pérez-García, Ma Dolores; Avilés-Flores, Margarita; Gutiérrez-Román, Ana Silvia; González-Cortazar, Manasés

doi:10.1016/j.micpath.2019.01.030

Cited by 39 publications

(19 citation statements)

References 27 publications

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“…In fact, the most active lignan in our assays, americanin A, exhibits antioxidant, antibacterial, and anti-tumor properties. It also inhibits melanin synthesis and matrix metalloproteinase-1 expression and enhances choline acetyltransferase activity [39]- [47]. We now know that lignans, especially those in noni fruit, may also influence endocannabinoid metabolism.…”

Section: Resultsmentioning

confidence: 99%

Lignans from Morinda citrifolia (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase in Vitro

West¹,

Deng²,

Jensen³

2020

JBM

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Morinda citrifolia (noni) fruit juice has exhibited a variety of biological activities in human clinical trials, indicating that it influences multiple systems of the body. Since the 1990s, the endocannabinoid system (ECS) has been found to modulate the activity of other organ systems. To investigate noni's potential impact on the ECS, extracts from freeze-dried noni fruit were evaluated in fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibition assays. The ethyl acetate extract demonstrated the greatest activity against both enzymes. Lignans in this extract also inhibited enzyme activities, with americanin A being the most active in both assays. Americanoic acid and 3,3'-bisdemethylpinoresinol were the next most active compounds. These results suggest that lignans in noni fruit may influence endocannabinoid levels within the body via FAAH and MAGL inhibition. This reveals another set of probable mechanisms of action by which noni juice affects human health.

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Section: Resultsmentioning

confidence: 99%

Lignans from Morinda citrifolia (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase in Vitro

West¹,

Deng²,

Jensen³

2020

JBM

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“…The methodology described in the literature was used [ 38 ]. The chemical composition of dichloromethane extract was analyzed on a gas chromatograph–mass spectrometry (GC-MS) equipped with a quadrupole mass detector in electron impact mode at 70 eV.…”

Section: Methodsmentioning

confidence: 99%

Corneal Healing and Recovery of Ocular Crystallinity with a Dichloromethane Extract of Sedum dendroideum D.C. in a Novel Murine Model of Ocular Pterygium

Labra

Jiménez-Ferrer²,

Camacho-Díaz

et al. 2021

Molecules

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Pterygium is a corneal alteration that can cause visual impairment, which has been traditionally treated with the sap of Sedum dendroideum D.C. The pharmacological effect of a dichloromethane extract of S. dendroideum was demonstrated and implemented in a pterygium model on the healing process of corneal damage caused by phorbol esters. In mice of the ICR strain, a corneal lesion was caused by intravitreal injection of tetradecanoylphorbol acetate (TPA). The evolution of the corneal scarring process was monitored with vehicle, dexamethasone, and dichloromethane extract of S. dendroideum treatments by daily ophthalmic administration for fifteen days. The lesions were evaluated in situ with highlighted images of fluorescence of the lesions. Following treatment levels in eyeballs of IL-1α, TNF-α, and IL-10 cytokines were measured. The effective dose of TPA to produce a pterygium-like lesion was determined. The follow-up of the evolution of the scarring process allowed us to define that the treatment with S. dendroideum improved the experimental pterygium and had an immunomodulatory effect by decreasing TNF-α, IL-1α, and maintaining the level of IL-10 expression, without difference with respect to the healthy control. Traditional medical use of S. dendroideum sap to treat pterygium is fully justified by its compound composition.

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“…The constituents of mengkudu have several biological activities such as antibacterial, antiviral, anti-tumor, and antifungal, thus playing a great role in the immune system [60,61]. The various parts of the plant including the fruit, flower, leaves (Figure 6), bark, and root are used in many traditional medicine preparations [62][63][64]. M. citrifolia fruit has remarkable hepatotoxicity effects owing to the presence of anthraquinones in the seeds and skin which had potent quinone reductase inducer activity [64].…”

Section: Mengkudu (Morinda Citrifolia L)mentioning

confidence: 99%

“…M. citrifolia fruit has remarkable hepatotoxicity effects owing to the presence of anthraquinones in the seeds and skin which had potent quinone reductase inducer activity [64]. It is also used to treat various other ailments such as respiratory-tract and skin infections [62]. M. citrifolia has broad healing properties and thus used for the treatment of anxiety, cancer, colds, flu, diabetes, blood pressure, and depression owing to the fruit's richness in phenolic compounds such as caffeine, chlorogenic acid, ellagic acid, gallic acid, quercetin, rutin, and rosmarinic acid [61].…”

Section: Mengkudu (Morinda Citrifolia L)mentioning

confidence: 99%

Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

Ahmed¹

2022

Natural Drugs From Plants

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Historically, natural products have always been a rich source of novel pharmacological leads, thus, making the ethnobotanical and ethnopharmacological knowledge an important and major asset of the medicinal plant-based drug discovery in providing hints for effective and safe chemotherapeutic compounds. Such knowledge, however, requires a thorough review and documentation of the ethnomedicinal and indigenous uses of local plants of every part of the world. Malaysia is a global hub for natural products which contributes to its GDP. Malaysia is also one of the 12 most diverse Megabiodiversity countries. Its rainforest is ranked 4th on the list of biodiversity hotspots in Asia after India, China, and Indonesia and is also acknowledged as the world’s oldest rainforest. Natural products are relevant to both Malaysian health care and agriculture which are parts of the national key economic areas (NKEA) under the Government’s Economic Transformation Plan as well as parts of the United Nations’ 17 Sustainable Development Goals (SDGs). Though the quality, efficacy, and safety of herbal products require global and international standardization, herbal products should be made accessible to low-income and rural communities across the globe. The proper documentation of the ethnopharmacological important plants in addition to their preservation and cultivation would enhance the sustainable use of the various indigenous plants. This work is unique in the sense that it is meant to review some of the most important high-value herbal products in Malaysia. Though it covers only a few representatives of Malaysian medicinal plants.

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Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp

Cited by 39 publications

References 27 publications

Lignans from <i>Morinda citrifolia</i> (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase <i>in Vitro</i>

Lignans from <i>Morinda citrifolia</i> (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase <i>in Vitro</i>

Corneal Healing and Recovery of Ocular Crystallinity with a Dichloromethane Extract of Sedum dendroideum D.C. in a Novel Murine Model of Ocular Pterygium

Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

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Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp

Cited by 39 publications

References 27 publications

Lignans from &lt;i&gt;Morinda citrifolia&lt;/i&gt; (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase &lt;i&gt;in Vitro&lt;/i&gt;

Lignans from &lt;i&gt;Morinda citrifolia&lt;/i&gt; (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase &lt;i&gt;in Vitro&lt;/i&gt;

Corneal Healing and Recovery of Ocular Crystallinity with a Dichloromethane Extract of Sedum dendroideum D.C. in a Novel Murine Model of Ocular Pterygium

Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

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Lignans from <i>Morinda citrifolia</i> (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase <i>in Vitro</i>

Lignans from <i>Morinda citrifolia</i> (Noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase <i>in Vitro</i>