2014
DOI: 10.1099/jmm.0.065441-0
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Antibacterial activity of moxifloxacin on bacteria associated with periodontitis within a biofilm

Abstract: The activity of moxifloxacin was compared with ofloxacin and doxycycline against bacteria associated with periodontitis within a biofilm (single strain and mixed population) in vitro. MICs and minimal bactericidal concentrations (MBCs) of moxifloxacin, ofloxacin and doxycyline were determined against single strains and mixed populations in a planktonic state. Single-species biofilms of two Porphyromonas gingivalis and two Aggregatibacter actinomycetemcomitans strains and a multispecies biofilm consisting of 12… Show more

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Cited by 26 publications
(21 citation statements)
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“…In other in vitro experiments, 2 % taurolidine solution reduced viability by 5-6 log10 CFU in Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans biofilms [30]. However, confirming a recent report [31], activity of antimicrobials is limited on a multi-species biofilm. Here, only the 100 % concentration of a 3 % taurolidine gel was able to reduce the CFU counts by more than 3 log10.…”
Section: Discussionmentioning
confidence: 70%
“…In other in vitro experiments, 2 % taurolidine solution reduced viability by 5-6 log10 CFU in Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans biofilms [30]. However, confirming a recent report [31], activity of antimicrobials is limited on a multi-species biofilm. Here, only the 100 % concentration of a 3 % taurolidine gel was able to reduce the CFU counts by more than 3 log10.…”
Section: Discussionmentioning
confidence: 70%
“…gingivalis and A . actinomycetemcomitans can be isolated from different hosts, despite that both bacteria strongly associate with periodontal disease [36,37], and can in fact trigger distinctive pathogenic pathways [38]. Still, P .…”
Section: Discussionmentioning
confidence: 99%
“…51 S. gordonii , A. naeslundii, F. nucleatum and P. gingivalis were selected to develop a periodontal four-species biofilm. 52 Briefly, 250 μL of S. gordonii suspension, 500 μL of A. naeslundii suspension, and 1000 μL of F. nucleatum and P. gingivalis suspensions were mixed and pipetted into 50 mL TSB supplemented medium.…”
Section: Methodsmentioning
confidence: 99%
“…52 Briefly, 250 μL of S. gordonii suspension, 500 μL of A. naeslundii suspension, and 1000 μL of F. nucleatum and P. gingivalis suspensions were mixed and pipetted into 50 mL TSB supplemented medium. 51 The sterile saliva pellicle-coated resin disks were transferred to a new 24-well plate. Each well was inoculated with 1.5 mL mixed bacterial suspension and incubated in anaerobic conditions (90% N 2 , 5% CO 2 , 5% H 2 ) at 37°C for 72 h, and the medium was changed every 24 h. 53 Plates containing only culture medium were also incubated to check for sterility.…”
Section: Methodsmentioning
confidence: 99%