Antibacterial activity of N-alkylated disaccharide chitosan derivatives

Yang, Tsui-Chu; Chou, Cheng‐Chun; Li, Chin-Fung

doi:10.1016/s0168-1605(03)00083-7

Cited by 186 publications

(106 citation statements)

References 23 publications

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“…Helander et al [72] reported that chitosan displayed antibacterial activity not only in an acid environment, although showed a stronger inhibitory effect at lower pHs with the inhibitory activity weakening with increasing pH. Kong et al [73] and Yang et al [74] observed that the antibacterial activity of the N-alkylated chitosan derivatives against E. coli increased as the pH rose from 5.0 reaching a maximum around pH 7.0-7.5. Also, the investigation of the antibacterial property of chitosan microspheres (CM) in a solid dispersing system showed that under neutral conditions, of the three tested CM samples with DA of 2.5, 16.5, 37.4% respectively, the highest inhibitory effect was observed for the CM sample with DA of 37.4% [73].…”

Section: Influence Of Phmentioning

confidence: 99%

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

et al. 2011

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Abstract:The physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (M W ) and degree of N-acetylation (DA), other physicochemical parameters like polydispersity (M W /M N ), crystallinity or the pattern of acetylation (P A ) have to be taken into consideration. From the biological point of view, these parameters affect a very important factor-the solubility of chitin and chitosan in water and organic solvents. The physicochemical properties of chitosan solutions can be controlled by manipulating solution conditions (temperature, pH, ionic strength, concentration, solvent). The degree of substitution of the hydroxyl and the amino groups or the degree of quaternization of the amino groups also influence the mechanical and biological properties of chitosan samples. Finally, a considerable research effort has been directed towards developing safe and efficient chitin/chitosan-based products because many factors, like the size of nanoparticles, can determine the biomedical characteristics of medicinal products. The influence of these factors on the biomedical activity of chitin/chitosan-based products is presented in this report in more detail. OPEN ACCESSPolymers 2011, 3 1876

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Section: Influence Of Phmentioning

confidence: 99%

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

et al. 2011

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“…Therefore, chitosan has been shown to inhibit food spoilage microorganisms such as Escherichia coli, Staphylococcus aureus and Candida sp. (Rhoades and Roller, 2000;Chung et al, 2005;Yang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Factors influencing antibacterial activity of chitosan against Aeromonas hydrophila and Staphylococcus aureus

et al. 2016

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In this study, the effect of the incubation time, incubation temperature, pH, metal and sodium ions on the antibacterial activity of chitosan against food borne spoilage bacteria focused. Aeromonas hydrophila and Staphylococcus aureus were used as two food borne bacteria. Acetic acid was used dissolving of chitosan. Results showed that chitosan solution at 5 mg/mL significantly inhibited the growth of A. hydrophila and S. aureus in presence of time, pH and metal ions (p <0.01). However, temperature did not significantly affect the antibacterial activity (4°C, 25°C and 37°C) (p >0.01). Chitosan activity increased with increasing incubation time. The influence of below pH 6 on the antibacterial activity of chitosan was significantly influenced (p<0.01). The addition of Ba+2 reduced chitosan activity against A. hydrophila while the addition of Ca+2 have increased chitosan activity against S. aureus. Sodium ions at a concentration of 25 mM reduced chitosan activity against S. aureus. These results show that chitosan can be used food industry to prevent the development of spoilage bacteria. Erdem et al., International Current Pharmaceutical Journal, April 2016, 5(5): 45-48

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“…Chitosan has attracted much attention as a biomedical material, as it exhibits a wide variety of biological activities, such as antitumor activities [7]- [9], immunostimulating effects [10], antiallergic effects [11], hemostatic agent [12], anticoagulant effects [13] [14] hypocholesterolemic effects [15], antiinflammatorty activities [16], free radical scavenging activities [17], antimicrobial effects [18], antibacterial effects [19] [20] wound-healing effects [21] [22], antifungal activities [23] [24] and antiviral activity [25]. However, because of its high molecular weight and water-insolubility, the applications of chitosan are severely limited.…”

Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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Antibacterial activity of N-alkylated disaccharide chitosan derivatives

Cited by 186 publications

References 23 publications

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

Factors influencing antibacterial activity of chitosan against Aeromonas hydrophila and Staphylococcus aureus

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

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